Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect in the forced swimming test in adrenocorticotropic hormone-treated rats
[Display omitted] •Tipepidine decreased the immobility in the forced swimming test in ACTH-treated rats.•The effect of tipepidine was blocked by a catecholamine-depleting agent.•The effect of tipepidine was blocked by a dopamine D1 receptor antagonist.•The effect of tipepidine was blocked by an adre...
Gespeichert in:
| Veröffentlicht in: | Behavioural brain research 2016-04, Vol.302, p.269-278 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 278 |
|---|---|
| container_issue | |
| container_start_page | 269 |
| container_title | Behavioural brain research |
| container_volume | 302 |
| creator | Kawaura, Kazuaki Ogata, Yukino Honda, Sokichi Soeda, Fumio Shirasaki, Tetsuya Takahama, Kazuo |
| description | [Display omitted]
•Tipepidine decreased the immobility in the forced swimming test in ACTH-treated rats.•The effect of tipepidine was blocked by a catecholamine-depleting agent.•The effect of tipepidine was blocked by a dopamine D1 receptor antagonist.•The effect of tipepidine was blocked by an adrenaline α2 receptor antagonist.•Tipepidine increased dopamine level of nucleus accumbens in ACTH-treated rats.
We investigated whether tipepidine exerts an antidepressant-like effect in the forced swimming test in adrenocorticotropic hormone (ACTH)-treated rats, which is known as a treatment-resistant depression model, and we studied the pharmacological mechanisms of the effects of tipepidine. Male Wistar rats (5–7 weeks old) were used in this study. Tipepidine (20 and 40mg/kg, i.p.) decreased the immobility time in the forced swimming test in ACTH-treated rats. The anti-immobility effect of tipepidine was blocked by a catecholamine-depleting agent, alpha-methyl-p-tyrosine (300mg/kg, s.c.), but not by a serotonin-depleting agent, p-chlorophenylalanine. The anti-immobility effect of tipepidine was also blocked by a dopamine D1 receptor antagonist, SCH23390 (0.02mg/kg, s.c.) and an adrenaline α2 receptor antagonist, yohimbine (2mg/kg, i.p.). In microdialysis technique, tipepidine (40mg/kg, i.p.) increased the extracellular dopamine level of the nucleus accumbens (NAc) in ACTH-treated rats. These results suggest that tipepidine exerts an antidepressant-like effect in the forced swimming test in ACTH-treated rats, and that the effect of tipepidine is mediated by the stimulation of dopamine D1 receptors and adrenaline α2 receptors. The results also suggest that an increase in the extracellular dopamine level in the NAc may be involved in the antidepressant-like effect of tipepidine in ACTH-treated rats. |
| doi_str_mv | 10.1016/j.bbr.2015.12.008 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1773822288</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0166432815303168</els_id><sourcerecordid>1768555234</sourcerecordid><originalsourceid>FETCH-LOGICAL-c452t-b2e215a91c1a5e94a440668b9d5242a8426102fc309394afcff9fe17581d21143</originalsourceid><addsrcrecordid>eNqNUctu1DAUtRCIDoUPYIO8ZEGCr2MnjlihikelSmzK2nKca-phYgfb08d_8MF4Oi1LxOpe3fOwdQ4hr4G1wKB_v22nKbWcgWyBt4ypJ2QDauDNIMX4lGwqp29Ex9UJeZHzljEmmITn5IT3Q6fGftyQ35d-xdXPPuA7amiIoQkm2Vi8pSYUX_Y5--uK4S2mkuvt_jzjmjDnujY7_xMpOoe2UB9ouULqYrI403zjl8WHH7RgvsfMnDBEG1N1jyXFtT5yFdMSAzYloSlVlEzJL8kzZ3YZXz3MU_L986fLs6_Nxbcv52cfLxorJC_NxJGDNCNYMBJHYYRgfa-mcZZccKME74FxZzs2dhV11rnRIQxSwcwBRHdK3h591xR_7esn9eKzxd3OBIz7rGGoMXHOlfoPaq-klLw7uMKRalPMOaHTa_KLSXcamD70pre69qYPvWnguvZWNW8e7PfTgvNfxWNRlfDhSMCax7XHpLP1GGrMPtXk9Rz9P-z_AKroquA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1768555234</pqid></control><display><type>article</type><title>Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect in the forced swimming test in adrenocorticotropic hormone-treated rats</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Kawaura, Kazuaki ; Ogata, Yukino ; Honda, Sokichi ; Soeda, Fumio ; Shirasaki, Tetsuya ; Takahama, Kazuo</creator><creatorcontrib>Kawaura, Kazuaki ; Ogata, Yukino ; Honda, Sokichi ; Soeda, Fumio ; Shirasaki, Tetsuya ; Takahama, Kazuo</creatorcontrib><description>[Display omitted]
•Tipepidine decreased the immobility in the forced swimming test in ACTH-treated rats.•The effect of tipepidine was blocked by a catecholamine-depleting agent.•The effect of tipepidine was blocked by a dopamine D1 receptor antagonist.•The effect of tipepidine was blocked by an adrenaline α2 receptor antagonist.•Tipepidine increased dopamine level of nucleus accumbens in ACTH-treated rats.
We investigated whether tipepidine exerts an antidepressant-like effect in the forced swimming test in adrenocorticotropic hormone (ACTH)-treated rats, which is known as a treatment-resistant depression model, and we studied the pharmacological mechanisms of the effects of tipepidine. Male Wistar rats (5–7 weeks old) were used in this study. Tipepidine (20 and 40mg/kg, i.p.) decreased the immobility time in the forced swimming test in ACTH-treated rats. The anti-immobility effect of tipepidine was blocked by a catecholamine-depleting agent, alpha-methyl-p-tyrosine (300mg/kg, s.c.), but not by a serotonin-depleting agent, p-chlorophenylalanine. The anti-immobility effect of tipepidine was also blocked by a dopamine D1 receptor antagonist, SCH23390 (0.02mg/kg, s.c.) and an adrenaline α2 receptor antagonist, yohimbine (2mg/kg, i.p.). In microdialysis technique, tipepidine (40mg/kg, i.p.) increased the extracellular dopamine level of the nucleus accumbens (NAc) in ACTH-treated rats. These results suggest that tipepidine exerts an antidepressant-like effect in the forced swimming test in ACTH-treated rats, and that the effect of tipepidine is mediated by the stimulation of dopamine D1 receptors and adrenaline α2 receptors. The results also suggest that an increase in the extracellular dopamine level in the NAc may be involved in the antidepressant-like effect of tipepidine in ACTH-treated rats.</description><identifier>ISSN: 0166-4328</identifier><identifier>EISSN: 1872-7549</identifier><identifier>DOI: 10.1016/j.bbr.2015.12.008</identifier><identifier>PMID: 26738969</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adrenocorticotropic Hormone - pharmacology ; Animals ; Antidepressive Agents - therapeutic use ; Antitussive ; Benzazepines - pharmacology ; Depression - drug therapy ; Depression - physiopathology ; Disease Models, Animal ; Dopamine ; Dopamine Antagonists - pharmacology ; Dose-Response Relationship, Drug ; Drug Interactions ; Fenclonine - pharmacology ; G protein-coupled inwardly rectifying potassium channel ; Hormones - pharmacology ; Imipramine - therapeutic use ; Immobility Response, Tonic - drug effects ; Locomotion - drug effects ; Male ; Piperidines - therapeutic use ; Rats ; Rats, Wistar ; Serotonin Antagonists - pharmacology ; Swimming - psychology ; Tipepidine ; Treatment-resistant depression</subject><ispartof>Behavioural brain research, 2016-04, Vol.302, p.269-278</ispartof><rights>2016</rights><rights>Copyright © 2016. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-b2e215a91c1a5e94a440668b9d5242a8426102fc309394afcff9fe17581d21143</citedby><cites>FETCH-LOGICAL-c452t-b2e215a91c1a5e94a440668b9d5242a8426102fc309394afcff9fe17581d21143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bbr.2015.12.008$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26738969$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kawaura, Kazuaki</creatorcontrib><creatorcontrib>Ogata, Yukino</creatorcontrib><creatorcontrib>Honda, Sokichi</creatorcontrib><creatorcontrib>Soeda, Fumio</creatorcontrib><creatorcontrib>Shirasaki, Tetsuya</creatorcontrib><creatorcontrib>Takahama, Kazuo</creatorcontrib><title>Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect in the forced swimming test in adrenocorticotropic hormone-treated rats</title><title>Behavioural brain research</title><addtitle>Behav Brain Res</addtitle><description>[Display omitted]
•Tipepidine decreased the immobility in the forced swimming test in ACTH-treated rats.•The effect of tipepidine was blocked by a catecholamine-depleting agent.•The effect of tipepidine was blocked by a dopamine D1 receptor antagonist.•The effect of tipepidine was blocked by an adrenaline α2 receptor antagonist.•Tipepidine increased dopamine level of nucleus accumbens in ACTH-treated rats.
We investigated whether tipepidine exerts an antidepressant-like effect in the forced swimming test in adrenocorticotropic hormone (ACTH)-treated rats, which is known as a treatment-resistant depression model, and we studied the pharmacological mechanisms of the effects of tipepidine. Male Wistar rats (5–7 weeks old) were used in this study. Tipepidine (20 and 40mg/kg, i.p.) decreased the immobility time in the forced swimming test in ACTH-treated rats. The anti-immobility effect of tipepidine was blocked by a catecholamine-depleting agent, alpha-methyl-p-tyrosine (300mg/kg, s.c.), but not by a serotonin-depleting agent, p-chlorophenylalanine. The anti-immobility effect of tipepidine was also blocked by a dopamine D1 receptor antagonist, SCH23390 (0.02mg/kg, s.c.) and an adrenaline α2 receptor antagonist, yohimbine (2mg/kg, i.p.). In microdialysis technique, tipepidine (40mg/kg, i.p.) increased the extracellular dopamine level of the nucleus accumbens (NAc) in ACTH-treated rats. These results suggest that tipepidine exerts an antidepressant-like effect in the forced swimming test in ACTH-treated rats, and that the effect of tipepidine is mediated by the stimulation of dopamine D1 receptors and adrenaline α2 receptors. The results also suggest that an increase in the extracellular dopamine level in the NAc may be involved in the antidepressant-like effect of tipepidine in ACTH-treated rats.</description><subject>Adrenocorticotropic Hormone - pharmacology</subject><subject>Animals</subject><subject>Antidepressive Agents - therapeutic use</subject><subject>Antitussive</subject><subject>Benzazepines - pharmacology</subject><subject>Depression - drug therapy</subject><subject>Depression - physiopathology</subject><subject>Disease Models, Animal</subject><subject>Dopamine</subject><subject>Dopamine Antagonists - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Interactions</subject><subject>Fenclonine - pharmacology</subject><subject>G protein-coupled inwardly rectifying potassium channel</subject><subject>Hormones - pharmacology</subject><subject>Imipramine - therapeutic use</subject><subject>Immobility Response, Tonic - drug effects</subject><subject>Locomotion - drug effects</subject><subject>Male</subject><subject>Piperidines - therapeutic use</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Serotonin Antagonists - pharmacology</subject><subject>Swimming - psychology</subject><subject>Tipepidine</subject><subject>Treatment-resistant depression</subject><issn>0166-4328</issn><issn>1872-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUctu1DAUtRCIDoUPYIO8ZEGCr2MnjlihikelSmzK2nKca-phYgfb08d_8MF4Oi1LxOpe3fOwdQ4hr4G1wKB_v22nKbWcgWyBt4ypJ2QDauDNIMX4lGwqp29Ex9UJeZHzljEmmITn5IT3Q6fGftyQ35d-xdXPPuA7amiIoQkm2Vi8pSYUX_Y5--uK4S2mkuvt_jzjmjDnujY7_xMpOoe2UB9ouULqYrI403zjl8WHH7RgvsfMnDBEG1N1jyXFtT5yFdMSAzYloSlVlEzJL8kzZ3YZXz3MU_L986fLs6_Nxbcv52cfLxorJC_NxJGDNCNYMBJHYYRgfa-mcZZccKME74FxZzs2dhV11rnRIQxSwcwBRHdK3h591xR_7esn9eKzxd3OBIz7rGGoMXHOlfoPaq-klLw7uMKRalPMOaHTa_KLSXcamD70pre69qYPvWnguvZWNW8e7PfTgvNfxWNRlfDhSMCax7XHpLP1GGrMPtXk9Rz9P-z_AKroquA</recordid><startdate>20160401</startdate><enddate>20160401</enddate><creator>Kawaura, Kazuaki</creator><creator>Ogata, Yukino</creator><creator>Honda, Sokichi</creator><creator>Soeda, Fumio</creator><creator>Shirasaki, Tetsuya</creator><creator>Takahama, Kazuo</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QG</scope><scope>7TK</scope></search><sort><creationdate>20160401</creationdate><title>Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect in the forced swimming test in adrenocorticotropic hormone-treated rats</title><author>Kawaura, Kazuaki ; Ogata, Yukino ; Honda, Sokichi ; Soeda, Fumio ; Shirasaki, Tetsuya ; Takahama, Kazuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-b2e215a91c1a5e94a440668b9d5242a8426102fc309394afcff9fe17581d21143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adrenocorticotropic Hormone - pharmacology</topic><topic>Animals</topic><topic>Antidepressive Agents - therapeutic use</topic><topic>Antitussive</topic><topic>Benzazepines - pharmacology</topic><topic>Depression - drug therapy</topic><topic>Depression - physiopathology</topic><topic>Disease Models, Animal</topic><topic>Dopamine</topic><topic>Dopamine Antagonists - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Interactions</topic><topic>Fenclonine - pharmacology</topic><topic>G protein-coupled inwardly rectifying potassium channel</topic><topic>Hormones - pharmacology</topic><topic>Imipramine - therapeutic use</topic><topic>Immobility Response, Tonic - drug effects</topic><topic>Locomotion - drug effects</topic><topic>Male</topic><topic>Piperidines - therapeutic use</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Serotonin Antagonists - pharmacology</topic><topic>Swimming - psychology</topic><topic>Tipepidine</topic><topic>Treatment-resistant depression</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kawaura, Kazuaki</creatorcontrib><creatorcontrib>Ogata, Yukino</creatorcontrib><creatorcontrib>Honda, Sokichi</creatorcontrib><creatorcontrib>Soeda, Fumio</creatorcontrib><creatorcontrib>Shirasaki, Tetsuya</creatorcontrib><creatorcontrib>Takahama, Kazuo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><jtitle>Behavioural brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawaura, Kazuaki</au><au>Ogata, Yukino</au><au>Honda, Sokichi</au><au>Soeda, Fumio</au><au>Shirasaki, Tetsuya</au><au>Takahama, Kazuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect in the forced swimming test in adrenocorticotropic hormone-treated rats</atitle><jtitle>Behavioural brain research</jtitle><addtitle>Behav Brain Res</addtitle><date>2016-04-01</date><risdate>2016</risdate><volume>302</volume><spage>269</spage><epage>278</epage><pages>269-278</pages><issn>0166-4328</issn><eissn>1872-7549</eissn><abstract>[Display omitted]
•Tipepidine decreased the immobility in the forced swimming test in ACTH-treated rats.•The effect of tipepidine was blocked by a catecholamine-depleting agent.•The effect of tipepidine was blocked by a dopamine D1 receptor antagonist.•The effect of tipepidine was blocked by an adrenaline α2 receptor antagonist.•Tipepidine increased dopamine level of nucleus accumbens in ACTH-treated rats.
We investigated whether tipepidine exerts an antidepressant-like effect in the forced swimming test in adrenocorticotropic hormone (ACTH)-treated rats, which is known as a treatment-resistant depression model, and we studied the pharmacological mechanisms of the effects of tipepidine. Male Wistar rats (5–7 weeks old) were used in this study. Tipepidine (20 and 40mg/kg, i.p.) decreased the immobility time in the forced swimming test in ACTH-treated rats. The anti-immobility effect of tipepidine was blocked by a catecholamine-depleting agent, alpha-methyl-p-tyrosine (300mg/kg, s.c.), but not by a serotonin-depleting agent, p-chlorophenylalanine. The anti-immobility effect of tipepidine was also blocked by a dopamine D1 receptor antagonist, SCH23390 (0.02mg/kg, s.c.) and an adrenaline α2 receptor antagonist, yohimbine (2mg/kg, i.p.). In microdialysis technique, tipepidine (40mg/kg, i.p.) increased the extracellular dopamine level of the nucleus accumbens (NAc) in ACTH-treated rats. These results suggest that tipepidine exerts an antidepressant-like effect in the forced swimming test in ACTH-treated rats, and that the effect of tipepidine is mediated by the stimulation of dopamine D1 receptors and adrenaline α2 receptors. The results also suggest that an increase in the extracellular dopamine level in the NAc may be involved in the antidepressant-like effect of tipepidine in ACTH-treated rats.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>26738969</pmid><doi>10.1016/j.bbr.2015.12.008</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0166-4328 |
| ispartof | Behavioural brain research, 2016-04, Vol.302, p.269-278 |
| issn | 0166-4328 1872-7549 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1773822288 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adrenocorticotropic Hormone - pharmacology Animals Antidepressive Agents - therapeutic use Antitussive Benzazepines - pharmacology Depression - drug therapy Depression - physiopathology Disease Models, Animal Dopamine Dopamine Antagonists - pharmacology Dose-Response Relationship, Drug Drug Interactions Fenclonine - pharmacology G protein-coupled inwardly rectifying potassium channel Hormones - pharmacology Imipramine - therapeutic use Immobility Response, Tonic - drug effects Locomotion - drug effects Male Piperidines - therapeutic use Rats Rats, Wistar Serotonin Antagonists - pharmacology Swimming - psychology Tipepidine Treatment-resistant depression |
| title | Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect in the forced swimming test in adrenocorticotropic hormone-treated rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T14%3A59%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Tipepidine,%20a%20non-narcotic%20antitussive,%20exerts%20an%20antidepressant-like%20effect%20in%20the%20forced%20swimming%20test%20in%20adrenocorticotropic%20hormone-treated%20rats&rft.jtitle=Behavioural%20brain%20research&rft.au=Kawaura,%20Kazuaki&rft.date=2016-04-01&rft.volume=302&rft.spage=269&rft.epage=278&rft.pages=269-278&rft.issn=0166-4328&rft.eissn=1872-7549&rft_id=info:doi/10.1016/j.bbr.2015.12.008&rft_dat=%3Cproquest_cross%3E1768555234%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1768555234&rft_id=info:pmid/26738969&rft_els_id=S0166432815303168&rfr_iscdi=true |