Dementia is a major risk factor for hip fractures in patients with chronic kidney disease
Summary Chronic kidney disease increases the risk of hip fractures which can be promoted by dementia. We here showed that dementia increased the risk of hip fractures in dialysis patients, but in a similar manner than without dialysis. Attention should be paid to dementia to prevent hip fractures. I...
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| Veröffentlicht in: | Osteoporosis international 2016-04, Vol.27 (4), p.1665-1669 |
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| creator | Maravic, M. Ostertag, A. Urena, P. Cohen-Solal, M. |
| description | Summary
Chronic kidney disease increases the risk of hip fractures which can be promoted by dementia. We here showed that dementia increased the risk of hip fractures in dialysis patients, but in a similar manner than without dialysis. Attention should be paid to dementia to prevent hip fractures.
Introduction
Hip fractures (HF) are associated with significant morbidity and is further increased in patients with chronic kidney disease (CKD). Dementia, frequent in CKD, might be a risk factor for HF. We here aimed to assess if dementia increased the risk of hip fracture in CKD.
Methods
The study was derived from the French National Database of Hospitalization. Data were obtained over the period 2011–2013. Three populations of subjects >60 years were extracted. Hip fractures, dialysis, and dementia were the main studied factors. The three populations were crossed to estimate the fracture risk based on dementia or dialysis, adjusted for age and gender. The fracture risk was calculated using a multiple logistic regression model.
Results
Over this period, 213,180 patients experienced a HF, 660,434 patients were diagnosed for dementia, and 47,430 patients were on dialysis. There was an effect of age and gender on the incidence of HF and dementia. In CKD patients, the risk of HF was significantly higher in demented patients compared to those without dementia: OR 2.0 [95 % CI 1.7–2.4], this being the same for men (OR 2.4 [1.8–3.1]) and women (OR 2.6 [2.0–3.3]) and at any age. However, the adjusted risk for HF in demented patients on dialysis therapy is not different than in demented patients without CKD (OR 1.3 [1.0–1.6]).
Conclusions
Dementia significantly increases the risk of HF in patients on dialysis, but this risk in demented patients is equally high whether receiving dialysis therapy or not. These results highlight dementia as a major risk factor for HF in dialysis and indicate that reduction of fracture risk should include dementia as a risk factor. |
| doi_str_mv | 10.1007/s00198-015-3429-y |
| format | Article |
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Chronic kidney disease increases the risk of hip fractures which can be promoted by dementia. We here showed that dementia increased the risk of hip fractures in dialysis patients, but in a similar manner than without dialysis. Attention should be paid to dementia to prevent hip fractures.
Introduction
Hip fractures (HF) are associated with significant morbidity and is further increased in patients with chronic kidney disease (CKD). Dementia, frequent in CKD, might be a risk factor for HF. We here aimed to assess if dementia increased the risk of hip fracture in CKD.
Methods
The study was derived from the French National Database of Hospitalization. Data were obtained over the period 2011–2013. Three populations of subjects >60 years were extracted. Hip fractures, dialysis, and dementia were the main studied factors. The three populations were crossed to estimate the fracture risk based on dementia or dialysis, adjusted for age and gender. The fracture risk was calculated using a multiple logistic regression model.
Results
Over this period, 213,180 patients experienced a HF, 660,434 patients were diagnosed for dementia, and 47,430 patients were on dialysis. There was an effect of age and gender on the incidence of HF and dementia. In CKD patients, the risk of HF was significantly higher in demented patients compared to those without dementia: OR 2.0 [95 % CI 1.7–2.4], this being the same for men (OR 2.4 [1.8–3.1]) and women (OR 2.6 [2.0–3.3]) and at any age. However, the adjusted risk for HF in demented patients on dialysis therapy is not different than in demented patients without CKD (OR 1.3 [1.0–1.6]).
Conclusions
Dementia significantly increases the risk of HF in patients on dialysis, but this risk in demented patients is equally high whether receiving dialysis therapy or not. These results highlight dementia as a major risk factor for HF in dialysis and indicate that reduction of fracture risk should include dementia as a risk factor.</description><identifier>ISSN: 0937-941X</identifier><identifier>EISSN: 1433-2965</identifier><identifier>DOI: 10.1007/s00198-015-3429-y</identifier><identifier>PMID: 26588907</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Age Distribution ; Aged ; Aged, 80 and over ; Bones ; Databases, Factual ; Dementia ; Dementia - complications ; Dementia - epidemiology ; Endocrinology ; Female ; Fractures ; France - epidemiology ; Hemodialysis ; Hip Fractures - epidemiology ; Hip Fractures - etiology ; Hip joint ; Humans ; Kidney diseases ; Kidney Failure, Chronic - complications ; Kidney Failure, Chronic - epidemiology ; Kidney Failure, Chronic - therapy ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Orthopedics ; Osteoporotic Fractures - epidemiology ; Osteoporotic Fractures - etiology ; Prevalence ; Renal Dialysis ; Rheumatology ; Risk Factors ; Sex Distribution ; Short Communication</subject><ispartof>Osteoporosis international, 2016-04, Vol.27 (4), p.1665-1669</ispartof><rights>International Osteoporosis Foundation and National Osteoporosis Foundation 2015</rights><rights>International Osteoporosis Foundation and National Osteoporosis Foundation 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-85b0b354d8032f42b9eb9ceaa3dd840c0a3e32b3ac1e306f649c79f1ddb19d973</citedby><cites>FETCH-LOGICAL-c372t-85b0b354d8032f42b9eb9ceaa3dd840c0a3e32b3ac1e306f649c79f1ddb19d973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00198-015-3429-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00198-015-3429-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26588907$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maravic, M.</creatorcontrib><creatorcontrib>Ostertag, A.</creatorcontrib><creatorcontrib>Urena, P.</creatorcontrib><creatorcontrib>Cohen-Solal, M.</creatorcontrib><title>Dementia is a major risk factor for hip fractures in patients with chronic kidney disease</title><title>Osteoporosis international</title><addtitle>Osteoporos Int</addtitle><addtitle>Osteoporos Int</addtitle><description>Summary
Chronic kidney disease increases the risk of hip fractures which can be promoted by dementia. We here showed that dementia increased the risk of hip fractures in dialysis patients, but in a similar manner than without dialysis. Attention should be paid to dementia to prevent hip fractures.
Introduction
Hip fractures (HF) are associated with significant morbidity and is further increased in patients with chronic kidney disease (CKD). Dementia, frequent in CKD, might be a risk factor for HF. We here aimed to assess if dementia increased the risk of hip fracture in CKD.
Methods
The study was derived from the French National Database of Hospitalization. Data were obtained over the period 2011–2013. Three populations of subjects >60 years were extracted. Hip fractures, dialysis, and dementia were the main studied factors. The three populations were crossed to estimate the fracture risk based on dementia or dialysis, adjusted for age and gender. The fracture risk was calculated using a multiple logistic regression model.
Results
Over this period, 213,180 patients experienced a HF, 660,434 patients were diagnosed for dementia, and 47,430 patients were on dialysis. There was an effect of age and gender on the incidence of HF and dementia. In CKD patients, the risk of HF was significantly higher in demented patients compared to those without dementia: OR 2.0 [95 % CI 1.7–2.4], this being the same for men (OR 2.4 [1.8–3.1]) and women (OR 2.6 [2.0–3.3]) and at any age. However, the adjusted risk for HF in demented patients on dialysis therapy is not different than in demented patients without CKD (OR 1.3 [1.0–1.6]).
Conclusions
Dementia significantly increases the risk of HF in patients on dialysis, but this risk in demented patients is equally high whether receiving dialysis therapy or not. These results highlight dementia as a major risk factor for HF in dialysis and indicate that reduction of fracture risk should include dementia as a risk factor.</description><subject>Age Distribution</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Bones</subject><subject>Databases, Factual</subject><subject>Dementia</subject><subject>Dementia - complications</subject><subject>Dementia - epidemiology</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Fractures</subject><subject>France - epidemiology</subject><subject>Hemodialysis</subject><subject>Hip Fractures - epidemiology</subject><subject>Hip Fractures - etiology</subject><subject>Hip joint</subject><subject>Humans</subject><subject>Kidney diseases</subject><subject>Kidney Failure, Chronic - complications</subject><subject>Kidney Failure, Chronic - epidemiology</subject><subject>Kidney Failure, Chronic - therapy</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Orthopedics</subject><subject>Osteoporotic Fractures - epidemiology</subject><subject>Osteoporotic Fractures - etiology</subject><subject>Prevalence</subject><subject>Renal Dialysis</subject><subject>Rheumatology</subject><subject>Risk Factors</subject><subject>Sex Distribution</subject><subject>Short Communication</subject><issn>0937-941X</issn><issn>1433-2965</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kE1LxDAURYMoOn78ADcScOOm-pK0TbMUv0Fwo6CrkCavTsZpOyYtMv_eDKMigouQhJx7XziEHDI4ZQDyLAIwVWXAikzkXGXLDTJhuRAZV2WxSSaghMxUzp53yG6MM0gZpeQ22eFlUVUK5IS8XGKL3eAN9ZEa2ppZH2jw8Y02xg7p3KQ19QvahHQfA0bqO7owg0-pSD_8MKV2GvrOW_rmXYdL6nxEE3GfbDVmHvHga98jT9dXjxe32f3Dzd3F-X1mheRDVhU11KLIXQWCNzmvFdbKojHCuSoHC0ag4LUwlqGAsilzZaVqmHM1U05JsUdO1r2L0L-PGAfd-mhxPjcd9mPUTEpRMZACEnr8B531Y-jS7zSruCrKomA8UWxN2dDHGLDRi-BbE5aagV5512vvOnnXK-96mTJHX81j3aL7SXyLTgBfAzE9da8Yfo3-t_UTicqOVg</recordid><startdate>20160401</startdate><enddate>20160401</enddate><creator>Maravic, M.</creator><creator>Ostertag, A.</creator><creator>Urena, P.</creator><creator>Cohen-Solal, M.</creator><general>Springer London</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20160401</creationdate><title>Dementia is a major risk factor for hip fractures in patients with chronic kidney disease</title><author>Maravic, M. ; Ostertag, A. ; Urena, P. ; Cohen-Solal, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-85b0b354d8032f42b9eb9ceaa3dd840c0a3e32b3ac1e306f649c79f1ddb19d973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Age Distribution</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Bones</topic><topic>Databases, Factual</topic><topic>Dementia</topic><topic>Dementia - complications</topic><topic>Dementia - epidemiology</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Fractures</topic><topic>France - epidemiology</topic><topic>Hemodialysis</topic><topic>Hip Fractures - epidemiology</topic><topic>Hip Fractures - etiology</topic><topic>Hip joint</topic><topic>Humans</topic><topic>Kidney diseases</topic><topic>Kidney Failure, Chronic - complications</topic><topic>Kidney Failure, Chronic - epidemiology</topic><topic>Kidney Failure, Chronic - therapy</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Orthopedics</topic><topic>Osteoporotic Fractures - epidemiology</topic><topic>Osteoporotic Fractures - etiology</topic><topic>Prevalence</topic><topic>Renal Dialysis</topic><topic>Rheumatology</topic><topic>Risk Factors</topic><topic>Sex Distribution</topic><topic>Short Communication</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maravic, M.</creatorcontrib><creatorcontrib>Ostertag, A.</creatorcontrib><creatorcontrib>Urena, P.</creatorcontrib><creatorcontrib>Cohen-Solal, M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Osteoporosis international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maravic, M.</au><au>Ostertag, A.</au><au>Urena, P.</au><au>Cohen-Solal, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dementia is a major risk factor for hip fractures in patients with chronic kidney disease</atitle><jtitle>Osteoporosis international</jtitle><stitle>Osteoporos Int</stitle><addtitle>Osteoporos Int</addtitle><date>2016-04-01</date><risdate>2016</risdate><volume>27</volume><issue>4</issue><spage>1665</spage><epage>1669</epage><pages>1665-1669</pages><issn>0937-941X</issn><eissn>1433-2965</eissn><abstract>Summary
Chronic kidney disease increases the risk of hip fractures which can be promoted by dementia. We here showed that dementia increased the risk of hip fractures in dialysis patients, but in a similar manner than without dialysis. Attention should be paid to dementia to prevent hip fractures.
Introduction
Hip fractures (HF) are associated with significant morbidity and is further increased in patients with chronic kidney disease (CKD). Dementia, frequent in CKD, might be a risk factor for HF. We here aimed to assess if dementia increased the risk of hip fracture in CKD.
Methods
The study was derived from the French National Database of Hospitalization. Data were obtained over the period 2011–2013. Three populations of subjects >60 years were extracted. Hip fractures, dialysis, and dementia were the main studied factors. The three populations were crossed to estimate the fracture risk based on dementia or dialysis, adjusted for age and gender. The fracture risk was calculated using a multiple logistic regression model.
Results
Over this period, 213,180 patients experienced a HF, 660,434 patients were diagnosed for dementia, and 47,430 patients were on dialysis. There was an effect of age and gender on the incidence of HF and dementia. In CKD patients, the risk of HF was significantly higher in demented patients compared to those without dementia: OR 2.0 [95 % CI 1.7–2.4], this being the same for men (OR 2.4 [1.8–3.1]) and women (OR 2.6 [2.0–3.3]) and at any age. However, the adjusted risk for HF in demented patients on dialysis therapy is not different than in demented patients without CKD (OR 1.3 [1.0–1.6]).
Conclusions
Dementia significantly increases the risk of HF in patients on dialysis, but this risk in demented patients is equally high whether receiving dialysis therapy or not. These results highlight dementia as a major risk factor for HF in dialysis and indicate that reduction of fracture risk should include dementia as a risk factor.</abstract><cop>London</cop><pub>Springer London</pub><pmid>26588907</pmid><doi>10.1007/s00198-015-3429-y</doi><tpages>5</tpages></addata></record> |
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| subjects | Age Distribution Aged Aged, 80 and over Bones Databases, Factual Dementia Dementia - complications Dementia - epidemiology Endocrinology Female Fractures France - epidemiology Hemodialysis Hip Fractures - epidemiology Hip Fractures - etiology Hip joint Humans Kidney diseases Kidney Failure, Chronic - complications Kidney Failure, Chronic - epidemiology Kidney Failure, Chronic - therapy Male Medicine Medicine & Public Health Middle Aged Orthopedics Osteoporotic Fractures - epidemiology Osteoporotic Fractures - etiology Prevalence Renal Dialysis Rheumatology Risk Factors Sex Distribution Short Communication |
| title | Dementia is a major risk factor for hip fractures in patients with chronic kidney disease |
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