The relationship between the failure to eradicate Helicobacter pylori and previous antibiotics use
Abstract Background The previous use of antibiotics is known to correlate positively with antibiotic resistance; whether this is also the case in the eradication of Helicobacter pylori infection is unclear. Aim To investigate the relationship between the previous use of antibiotics and the failure o...
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| Veröffentlicht in: | Digestive and liver disease 2016-04, Vol.48 (4), p.385-390 |
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| creator | Lim, Sun Gyo Park, Rae Woong Shin, Sung Jae Yoon, Dukyong Kang, Joon Koo Hwang, Jae Chul Kim, Soon Sun Kim, Jin Hong Lee, Kee Myung |
| description | Abstract Background The previous use of antibiotics is known to correlate positively with antibiotic resistance; whether this is also the case in the eradication of Helicobacter pylori infection is unclear. Aim To investigate the relationship between the previous use of antibiotics and the failure of eradication therapy in H. pylori infection. Methods The relationship between the clinical parameters and the failure of H. pylori eradication was analyzed in patients administered standard triple therapy and then assessed for the eradication of H. pylori based on a C13-urea breath test. Results In a multivariate analysis, failure rates increased significantly in patients with a history of clarithromycin (odds ratio [OR], 4.445) or other macrolides (OR, 2.407) use, who were female (OR, 1.339), or who were older than 60 years of age (OR, 1.326). The eradication failure rate in patients with a history of macrolides use for >2 weeks was significantly higher than if the duration of use was |
| doi_str_mv | 10.1016/j.dld.2015.12.001 |
| format | Article |
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Aim To investigate the relationship between the previous use of antibiotics and the failure of eradication therapy in H. pylori infection. Methods The relationship between the clinical parameters and the failure of H. pylori eradication was analyzed in patients administered standard triple therapy and then assessed for the eradication of H. pylori based on a C13-urea breath test. Results In a multivariate analysis, failure rates increased significantly in patients with a history of clarithromycin (odds ratio [OR], 4.445) or other macrolides (OR, 2.407) use, who were female (OR, 1.339), or who were older than 60 years of age (OR, 1.326). The eradication failure rate in patients with a history of macrolides use for >2 weeks was significantly higher than if the duration of use was <2 weeks (44.8% vs. 29.3%, p = 0.047). Conclusions A patient's history of macrolides is a useful predictor of the likelihood of standard triple therapy failure in H. pylori eradication. The alternatives such as a bismuth-based quadruple or a levofloxacin-containing therapy should be considered in patients treated with macrolides for >2 weeks.</description><identifier>ISSN: 1590-8658</identifier><identifier>EISSN: 1878-3562</identifier><identifier>DOI: 10.1016/j.dld.2015.12.001</identifier><identifier>PMID: 26856963</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adult ; Aged ; Anti-Bacterial Agents - administration & dosage ; Bismuth - therapeutic use ; Breath Tests ; Clarithromycin ; Clarithromycin - administration & dosage ; Drug resistance ; Drug Resistance, Bacterial ; Female ; Gastroenterology and Hepatology ; Helicobacter Infections - drug therapy ; Helicobacter pylori ; Helicobacter pylori - drug effects ; Hospitals, Teaching ; Humans ; Levofloxacin - therapeutic use ; Logistic Models ; Macrolides ; Macrolides - administration & dosage ; Male ; Microbial ; Middle Aged ; Multivariate Analysis ; Republic of Korea ; Retrospective Studies ; Tertiary Care Centers</subject><ispartof>Digestive and liver disease, 2016-04, Vol.48 (4), p.385-390</ispartof><rights>2016</rights><rights>Copyright © 2016. Published by Elsevier Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-c093e227094f4ced076088f93d4fc1ec2e5383523240abd86dfadfc08d183e5d3</citedby><cites>FETCH-LOGICAL-c408t-c093e227094f4ced076088f93d4fc1ec2e5383523240abd86dfadfc08d183e5d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.dld.2015.12.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26856963$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lim, Sun Gyo</creatorcontrib><creatorcontrib>Park, Rae Woong</creatorcontrib><creatorcontrib>Shin, Sung Jae</creatorcontrib><creatorcontrib>Yoon, Dukyong</creatorcontrib><creatorcontrib>Kang, Joon Koo</creatorcontrib><creatorcontrib>Hwang, Jae Chul</creatorcontrib><creatorcontrib>Kim, Soon Sun</creatorcontrib><creatorcontrib>Kim, Jin Hong</creatorcontrib><creatorcontrib>Lee, Kee Myung</creatorcontrib><title>The relationship between the failure to eradicate Helicobacter pylori and previous antibiotics use</title><title>Digestive and liver disease</title><addtitle>Dig Liver Dis</addtitle><description>Abstract Background The previous use of antibiotics is known to correlate positively with antibiotic resistance; whether this is also the case in the eradication of Helicobacter pylori infection is unclear. Aim To investigate the relationship between the previous use of antibiotics and the failure of eradication therapy in H. pylori infection. Methods The relationship between the clinical parameters and the failure of H. pylori eradication was analyzed in patients administered standard triple therapy and then assessed for the eradication of H. pylori based on a C13-urea breath test. Results In a multivariate analysis, failure rates increased significantly in patients with a history of clarithromycin (odds ratio [OR], 4.445) or other macrolides (OR, 2.407) use, who were female (OR, 1.339), or who were older than 60 years of age (OR, 1.326). The eradication failure rate in patients with a history of macrolides use for >2 weeks was significantly higher than if the duration of use was <2 weeks (44.8% vs. 29.3%, p = 0.047). Conclusions A patient's history of macrolides is a useful predictor of the likelihood of standard triple therapy failure in H. pylori eradication. The alternatives such as a bismuth-based quadruple or a levofloxacin-containing therapy should be considered in patients treated with macrolides for >2 weeks.</description><subject>Adult</subject><subject>Aged</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Bismuth - therapeutic use</subject><subject>Breath Tests</subject><subject>Clarithromycin</subject><subject>Clarithromycin - administration & dosage</subject><subject>Drug resistance</subject><subject>Drug Resistance, Bacterial</subject><subject>Female</subject><subject>Gastroenterology and Hepatology</subject><subject>Helicobacter Infections - drug therapy</subject><subject>Helicobacter pylori</subject><subject>Helicobacter pylori - drug effects</subject><subject>Hospitals, Teaching</subject><subject>Humans</subject><subject>Levofloxacin - therapeutic use</subject><subject>Logistic Models</subject><subject>Macrolides</subject><subject>Macrolides - administration & dosage</subject><subject>Male</subject><subject>Microbial</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Republic of Korea</subject><subject>Retrospective Studies</subject><subject>Tertiary Care Centers</subject><issn>1590-8658</issn><issn>1878-3562</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUGLFDEQhYMo7jr6A7xIjl66rSSd7jSCIIu6woIHV_AW0kk1mzHTaZP0yvx7M8zqwYOnSpH3HlVfEfKSQcuA9W_2rQuu5cBky3gLwB6RS6YG1QjZ88f1LUdoVC_VBXmW8x6As17CU3LBeyX7sReXZLq9Q5owmOLjku_8SicsvxAXWurHbHzYEtISKSbjvDUF6TUGb-NkbMFE12OIyVOzOLomvPdxy7UpfvKxeJvplvE5eTKbkPHFQ92Rbx8_3F5dNzdfPn2-en_T2A5UaSyMAjkfYOzmzqKDoQel5lG4brYMLUcplJBc8A7M5FTvZuNmC8oxJVA6sSOvz7lrij83zEUffLYYglmwjqXZMAgFA6vyHWFnqU0x54SzXpM_mHTUDPQJrd7rilaf0GrGdUVbPa8e4rfpgO6v4w_LKnh7FmBd8t5j0tl6XOoqPqEt2kX_3_h3_7ht8EslHn7gEfM-bmmp9DTTuRr019NtT6dlUgCX4rv4Dda9n8A</recordid><startdate>20160401</startdate><enddate>20160401</enddate><creator>Lim, Sun Gyo</creator><creator>Park, Rae Woong</creator><creator>Shin, Sung Jae</creator><creator>Yoon, Dukyong</creator><creator>Kang, Joon Koo</creator><creator>Hwang, Jae Chul</creator><creator>Kim, Soon Sun</creator><creator>Kim, Jin Hong</creator><creator>Lee, Kee Myung</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160401</creationdate><title>The relationship between the failure to eradicate Helicobacter pylori and previous antibiotics use</title><author>Lim, Sun Gyo ; Park, Rae Woong ; Shin, Sung Jae ; Yoon, Dukyong ; Kang, Joon Koo ; Hwang, Jae Chul ; Kim, Soon Sun ; Kim, Jin Hong ; Lee, Kee Myung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-c093e227094f4ced076088f93d4fc1ec2e5383523240abd86dfadfc08d183e5d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Bismuth - therapeutic use</topic><topic>Breath Tests</topic><topic>Clarithromycin</topic><topic>Clarithromycin - administration & dosage</topic><topic>Drug resistance</topic><topic>Drug Resistance, Bacterial</topic><topic>Female</topic><topic>Gastroenterology and Hepatology</topic><topic>Helicobacter Infections - drug therapy</topic><topic>Helicobacter pylori</topic><topic>Helicobacter pylori - drug effects</topic><topic>Hospitals, Teaching</topic><topic>Humans</topic><topic>Levofloxacin - therapeutic use</topic><topic>Logistic Models</topic><topic>Macrolides</topic><topic>Macrolides - administration & dosage</topic><topic>Male</topic><topic>Microbial</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Republic of Korea</topic><topic>Retrospective Studies</topic><topic>Tertiary Care Centers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lim, Sun Gyo</creatorcontrib><creatorcontrib>Park, Rae Woong</creatorcontrib><creatorcontrib>Shin, Sung Jae</creatorcontrib><creatorcontrib>Yoon, Dukyong</creatorcontrib><creatorcontrib>Kang, Joon Koo</creatorcontrib><creatorcontrib>Hwang, Jae Chul</creatorcontrib><creatorcontrib>Kim, Soon Sun</creatorcontrib><creatorcontrib>Kim, Jin Hong</creatorcontrib><creatorcontrib>Lee, Kee Myung</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive and liver disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lim, Sun Gyo</au><au>Park, Rae Woong</au><au>Shin, Sung Jae</au><au>Yoon, Dukyong</au><au>Kang, Joon Koo</au><au>Hwang, Jae Chul</au><au>Kim, Soon Sun</au><au>Kim, Jin Hong</au><au>Lee, Kee Myung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relationship between the failure to eradicate Helicobacter pylori and previous antibiotics use</atitle><jtitle>Digestive and liver disease</jtitle><addtitle>Dig Liver Dis</addtitle><date>2016-04-01</date><risdate>2016</risdate><volume>48</volume><issue>4</issue><spage>385</spage><epage>390</epage><pages>385-390</pages><issn>1590-8658</issn><eissn>1878-3562</eissn><abstract>Abstract Background The previous use of antibiotics is known to correlate positively with antibiotic resistance; whether this is also the case in the eradication of Helicobacter pylori infection is unclear. Aim To investigate the relationship between the previous use of antibiotics and the failure of eradication therapy in H. pylori infection. Methods The relationship between the clinical parameters and the failure of H. pylori eradication was analyzed in patients administered standard triple therapy and then assessed for the eradication of H. pylori based on a C13-urea breath test. Results In a multivariate analysis, failure rates increased significantly in patients with a history of clarithromycin (odds ratio [OR], 4.445) or other macrolides (OR, 2.407) use, who were female (OR, 1.339), or who were older than 60 years of age (OR, 1.326). The eradication failure rate in patients with a history of macrolides use for >2 weeks was significantly higher than if the duration of use was <2 weeks (44.8% vs. 29.3%, p = 0.047). Conclusions A patient's history of macrolides is a useful predictor of the likelihood of standard triple therapy failure in H. pylori eradication. The alternatives such as a bismuth-based quadruple or a levofloxacin-containing therapy should be considered in patients treated with macrolides for >2 weeks.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>26856963</pmid><doi>10.1016/j.dld.2015.12.001</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Aged Anti-Bacterial Agents - administration & dosage Bismuth - therapeutic use Breath Tests Clarithromycin Clarithromycin - administration & dosage Drug resistance Drug Resistance, Bacterial Female Gastroenterology and Hepatology Helicobacter Infections - drug therapy Helicobacter pylori Helicobacter pylori - drug effects Hospitals, Teaching Humans Levofloxacin - therapeutic use Logistic Models Macrolides Macrolides - administration & dosage Male Microbial Middle Aged Multivariate Analysis Republic of Korea Retrospective Studies Tertiary Care Centers |
| title | The relationship between the failure to eradicate Helicobacter pylori and previous antibiotics use |
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