Loss of Runx3 Function in Leukocytes Is Associated with Spontaneously Developed Colitis and Gastric Mucosal Hyperplasia

RUNX transcription factors are key regulators of lineage-specific gene expression and might be involved in autoimmune diseases. Runx3 plays a role during the development of sensory neurons and T cells and regulates transforming growth factor β (TGF-β) signaling in dendritic cells. Here, we report th...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2004-11, Vol.101 (45), p.16016-16021
Hauptverfasser:	Brenner, Ori, Levanon, Ditsa, Negreanu, Varda, Golubkov, Olga, Fainaru, Ofer, Woolf, Eilon, Groner, Yoram, Sachs, Leo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoimmune diseases B lymphocytes Biological Sciences Bowel disease Colitis Colitis - etiology Colitis - genetics Colitis - pathology Colitis - physiopathology Core Binding Factor Alpha 3 Subunit Cytokines Cytokines - metabolism DNA-Binding Proteins - deficiency DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Gastric Mucosa - immunology Gastric Mucosa - pathology Gastrointestinal tract Gene expression Humans Hyperplasia Immunohistochemistry In Situ Hybridization Inflammatory bowel diseases Inflammatory Bowel Diseases - etiology Inflammatory Bowel Diseases - genetics Inflammatory Bowel Diseases - pathology Inflammatory Bowel Diseases - physiopathology Lesions Leukocytes Leukocytes - pathology Leukocytes - physiology Medical research Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Mucosa Stomach T lymphocytes Th1 Cells - immunology Th1 Cells - pathology Th2 Cells - immunology Th2 Cells - pathology Transcription Factors - deficiency Transcription Factors - genetics Transcription Factors - physiology
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