Immunolocalization of connexin 26 in the developing mouse cochlea
Gap junctions play a pivotal role in embryonic development by forming specialized regions of cell–cell communication. In this study, we demonstrate the temporal–spatial distribution of connexin 26 in the embryonic and early postnatal mouse cochlea. Our results show localization of this gap junction...
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| Veröffentlicht in: | Brain Research Reviews 2000-04, Vol.32 (1), p.172-180 |
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| creator | Frenz, Christopher M Van De Water, Thomas R |
| description | Gap junctions play a pivotal role in embryonic development by forming specialized regions of cell–cell communication. In this study, we demonstrate the temporal–spatial distribution of connexin 26 in the embryonic and early postnatal mouse cochlea. Our results show localization of this gap junction protein to specific cochlear structures, including the inner and outer sulcus cells, the supporting cells of the inner hair cells, the mesenchyme derived portion of the stria vascularis, and the cells of the spiral ligament that interface with the basal cells of the stria vascularis. This suggests that this gap junction protein of served patterns of connexin 26 distribution is important for the differentiation and development of these structures (e.g., the role of the inner sulcus cells in producing the tectorial membrane). |
| doi_str_mv | 10.1016/S0165-0173(99)00078-8 |
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In this study, we demonstrate the temporal–spatial distribution of connexin 26 in the embryonic and early postnatal mouse cochlea. Our results show localization of this gap junction protein to specific cochlear structures, including the inner and outer sulcus cells, the supporting cells of the inner hair cells, the mesenchyme derived portion of the stria vascularis, and the cells of the spiral ligament that interface with the basal cells of the stria vascularis. 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In this study, we demonstrate the temporal–spatial distribution of connexin 26 in the embryonic and early postnatal mouse cochlea. Our results show localization of this gap junction protein to specific cochlear structures, including the inner and outer sulcus cells, the supporting cells of the inner hair cells, the mesenchyme derived portion of the stria vascularis, and the cells of the spiral ligament that interface with the basal cells of the stria vascularis. 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Psychology</subject><subject>Gap junction</subject><subject>Gap Junctions - chemistry</subject><subject>Gap Junctions - metabolism</subject><subject>Hair Cells, Auditory, Inner - chemistry</subject><subject>Hair Cells, Auditory, Inner - cytology</subject><subject>Hair Cells, Auditory, Inner - embryology</subject><subject>Hair Cells, Auditory, Outer - chemistry</subject><subject>Hair Cells, Auditory, Outer - cytology</subject><subject>Hair Cells, Auditory, Outer - embryology</subject><subject>Immunohistochemistry</subject><subject>inner sulcus cells</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Inbred CBA</subject><subject>Pregnancy</subject><subject>tectorial membrane</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0165-0173</issn><issn>1872-6321</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0MtO3DAUgGGrApVh2kdolQVCsEhrJ75lhUYI6EgjsWi7tk6cEzBK7GmcIMrT47moZQcbe_Md--gn5Auj3xhl8vvPdIicMlWeVdU5pVTpXH8gM6ZVkcuyYAdk9o8ckeMYHygVFdfyIzliVAkmpZqRxbLvJx-6YKFzzzC64LPQZjZ4j0_OZ4XM0jneY9bgI3Zh7fxd1ocpYjL2vkP4RA5b6CJ-3t9z8vv66tflj3x1e7O8XKxyy7Ua87YFWYOAskTgwAVUomQaZFOCsLwFK6kual1XWquW17QQdW0tUFpoRCmack5Od--uh_Bnwjia3kWLXQce0z6GKVXqxN8BRcG52ECxg3YIMQ7YmvXgehj-GkbNJrLZRjabgqaqzDay0Wnu6_6Dqe6xeTW1q5rAyR5ATF3bAbx18b_jaUtNE7vYMUzZHh0OJlqH3mLjBrSjaYJ7Y5MX2JuYaA</recordid><startdate>20000401</startdate><enddate>20000401</enddate><creator>Frenz, Christopher M</creator><creator>Van De Water, Thomas R</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>20000401</creationdate><title>Immunolocalization of connexin 26 in the developing mouse cochlea</title><author>Frenz, Christopher M ; Van De Water, Thomas R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-ffa6ba5a33ea4a45a95318a6d3a5c4fac6082b8b9887f4b025bbcca0028ee65d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Differentiation - physiology</topic><topic>Cochlea</topic><topic>Connexin 26</topic><topic>Connexins - analysis</topic><topic>Connexins - biosynthesis</topic><topic>Development</topic><topic>Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gap junction</topic><topic>Gap Junctions - chemistry</topic><topic>Gap Junctions - metabolism</topic><topic>Hair Cells, Auditory, Inner - chemistry</topic><topic>Hair Cells, Auditory, Inner - cytology</topic><topic>Hair Cells, Auditory, Inner - embryology</topic><topic>Hair Cells, Auditory, Outer - chemistry</topic><topic>Hair Cells, Auditory, Outer - cytology</topic><topic>Hair Cells, Auditory, Outer - embryology</topic><topic>Immunohistochemistry</topic><topic>inner sulcus cells</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Inbred CBA</topic><topic>Pregnancy</topic><topic>tectorial membrane</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Frenz, Christopher M</creatorcontrib><creatorcontrib>Van De Water, Thomas R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Brain Research Reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Frenz, Christopher M</au><au>Van De Water, Thomas R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunolocalization of connexin 26 in the developing mouse cochlea</atitle><jtitle>Brain Research Reviews</jtitle><addtitle>Brain Res Brain Res Rev</addtitle><date>2000-04-01</date><risdate>2000</risdate><volume>32</volume><issue>1</issue><spage>172</spage><epage>180</epage><pages>172-180</pages><issn>0165-0173</issn><eissn>1872-6321</eissn><abstract>Gap junctions play a pivotal role in embryonic development by forming specialized regions of cell–cell communication. 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| subjects | Animals Biological and medical sciences Cell Differentiation - physiology Cochlea Connexin 26 Connexins - analysis Connexins - biosynthesis Development Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation Female Fundamental and applied biological sciences. Psychology Gap junction Gap Junctions - chemistry Gap Junctions - metabolism Hair Cells, Auditory, Inner - chemistry Hair Cells, Auditory, Inner - cytology Hair Cells, Auditory, Inner - embryology Hair Cells, Auditory, Outer - chemistry Hair Cells, Auditory, Outer - cytology Hair Cells, Auditory, Outer - embryology Immunohistochemistry inner sulcus cells Male Mice Mice, Inbred C57BL Mice, Inbred CBA Pregnancy tectorial membrane Vertebrates: nervous system and sense organs |
| title | Immunolocalization of connexin 26 in the developing mouse cochlea |
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