Inhaled Zanamivir for the Prevention of Influenza in Families
Influenzaviruses are frequently transmitted within households. In some epidemics, up to 50 percent of households have one or more members who become infected. The average secondary attack rates among family members is 25 percent, 1 although family composition, the circulating viral strain, and the p...
Gespeichert in:
| Veröffentlicht in: | The New England journal of medicine 2000-11, Vol.343 (18), p.1282-1289 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1289 |
|---|---|
| container_issue | 18 |
| container_start_page | 1282 |
| container_title | The New England journal of medicine |
| container_volume | 343 |
| creator | Hayden, Frederick G Gubareva, Larisa V Monto, Arnold S Klein, Thomas C Elliott, Michael J Hammond, Janet M Sharp, Stephen J Ossi, Michael J |
| description | Influenzaviruses are frequently transmitted within households. In some epidemics, up to 50 percent of households have one or more members who become infected. The average secondary attack rates among family members is 25 percent,
1
although family composition, the circulating viral strain, and the presence or absence of exposure outside the household
2
influence the likelihood of secondary cases.
Amantadine and rimantadine selectively inhibit the ion-channel function of the M2 protein of influenza A viruses.
3
These drugs have been used for postexposure prophylaxis in households, with reductions in influenza among family members (household contacts) of the index patient ranging from 3 to . . . |
| doi_str_mv | 10.1056/NEJM200011023431801 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_17737750</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>63053541</sourcerecordid><originalsourceid>FETCH-LOGICAL-c571t-e1a8c6db62ec945bc47236db60277eb9bee8c7421a023b049a600df7674dd07e3</originalsourceid><addsrcrecordid>eNp9kEtLw0AUhQdRsFZ_gZug4Eaidx7JNAsXUlqt1MdCN26GyeSGpiSTOpMU9Nc7pcWFiKvLhe98HA4hpxSuKCTp9dPk4ZEBAKXAuOB0BHSPDGjCeSwEpPtkAMBGsZAZPyRH3i9hA4tsQG5mdqFrLKJ3bXVTrSsXla2LugVGLw7XaLuqtVFbRjNb1j3aLx1VNpoGtK7QH5ODUtceT3Z3SN6mk9fxfTx_vpuNb-exSSTtYqR6ZNIiTxmaTCS5EZLxzQ9MSsyzHHFkpGBUh_o5iEynAEUpUymKAiTyIbnYeleu_ejRd6qpvMG61hbb3isqJZcygQCe_QKXbe9s6KYY41kS3FmA-BYyrvXeYalWrmq0-1QU1GZP9ceeIXW-U2tvdF06bU3lf6IyYyyRgbrcUk3jlcVl86_zG5oTfu8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>223950499</pqid></control><display><type>article</type><title>Inhaled Zanamivir for the Prevention of Influenza in Families</title><source>EZB Electronic Journals Library</source><source>New England Journal of Medicine</source><creator>Hayden, Frederick G ; Gubareva, Larisa V ; Monto, Arnold S ; Klein, Thomas C ; Elliott, Michael J ; Hammond, Janet M ; Sharp, Stephen J ; Ossi, Michael J</creator><creatorcontrib>Hayden, Frederick G ; Gubareva, Larisa V ; Monto, Arnold S ; Klein, Thomas C ; Elliott, Michael J ; Hammond, Janet M ; Sharp, Stephen J ; Ossi, Michael J</creatorcontrib><description>Influenzaviruses are frequently transmitted within households. In some epidemics, up to 50 percent of households have one or more members who become infected. The average secondary attack rates among family members is 25 percent,
1
although family composition, the circulating viral strain, and the presence or absence of exposure outside the household
2
influence the likelihood of secondary cases.
Amantadine and rimantadine selectively inhibit the ion-channel function of the M2 protein of influenza A viruses.
3
These drugs have been used for postexposure prophylaxis in households, with reductions in influenza among family members (household contacts) of the index patient ranging from 3 to . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM200011023431801</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiviral agents ; Biological and medical sciences ; Drug dosages ; Drug resistance ; Households ; Influenza virus ; Medical sciences ; Pharmacology. Drug treatments ; zanamivir</subject><ispartof>The New England journal of medicine, 2000-11, Vol.343 (18), p.1282-1289</ispartof><rights>Copyright © 2000 Massachusetts Medical Society. All rights reserved.</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c571t-e1a8c6db62ec945bc47236db60277eb9bee8c7421a023b049a600df7674dd07e3</citedby><cites>FETCH-LOGICAL-c571t-e1a8c6db62ec945bc47236db60277eb9bee8c7421a023b049a600df7674dd07e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM200011023431801$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJM200011023431801$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=792257$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Hayden, Frederick G</creatorcontrib><creatorcontrib>Gubareva, Larisa V</creatorcontrib><creatorcontrib>Monto, Arnold S</creatorcontrib><creatorcontrib>Klein, Thomas C</creatorcontrib><creatorcontrib>Elliott, Michael J</creatorcontrib><creatorcontrib>Hammond, Janet M</creatorcontrib><creatorcontrib>Sharp, Stephen J</creatorcontrib><creatorcontrib>Ossi, Michael J</creatorcontrib><title>Inhaled Zanamivir for the Prevention of Influenza in Families</title><title>The New England journal of medicine</title><description>Influenzaviruses are frequently transmitted within households. In some epidemics, up to 50 percent of households have one or more members who become infected. The average secondary attack rates among family members is 25 percent,
1
although family composition, the circulating viral strain, and the presence or absence of exposure outside the household
2
influence the likelihood of secondary cases.
Amantadine and rimantadine selectively inhibit the ion-channel function of the M2 protein of influenza A viruses.
3
These drugs have been used for postexposure prophylaxis in households, with reductions in influenza among family members (household contacts) of the index patient ranging from 3 to . . .</description><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiviral agents</subject><subject>Biological and medical sciences</subject><subject>Drug dosages</subject><subject>Drug resistance</subject><subject>Households</subject><subject>Influenza virus</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>zanamivir</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kEtLw0AUhQdRsFZ_gZug4Eaidx7JNAsXUlqt1MdCN26GyeSGpiSTOpMU9Nc7pcWFiKvLhe98HA4hpxSuKCTp9dPk4ZEBAKXAuOB0BHSPDGjCeSwEpPtkAMBGsZAZPyRH3i9hA4tsQG5mdqFrLKJ3bXVTrSsXla2LugVGLw7XaLuqtVFbRjNb1j3aLx1VNpoGtK7QH5ODUtceT3Z3SN6mk9fxfTx_vpuNb-exSSTtYqR6ZNIiTxmaTCS5EZLxzQ9MSsyzHHFkpGBUh_o5iEynAEUpUymKAiTyIbnYeleu_ejRd6qpvMG61hbb3isqJZcygQCe_QKXbe9s6KYY41kS3FmA-BYyrvXeYalWrmq0-1QU1GZP9ceeIXW-U2tvdF06bU3lf6IyYyyRgbrcUk3jlcVl86_zG5oTfu8</recordid><startdate>20001102</startdate><enddate>20001102</enddate><creator>Hayden, Frederick G</creator><creator>Gubareva, Larisa V</creator><creator>Monto, Arnold S</creator><creator>Klein, Thomas C</creator><creator>Elliott, Michael J</creator><creator>Hammond, Janet M</creator><creator>Sharp, Stephen J</creator><creator>Ossi, Michael J</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>20001102</creationdate><title>Inhaled Zanamivir for the Prevention of Influenza in Families</title><author>Hayden, Frederick G ; Gubareva, Larisa V ; Monto, Arnold S ; Klein, Thomas C ; Elliott, Michael J ; Hammond, Janet M ; Sharp, Stephen J ; Ossi, Michael J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c571t-e1a8c6db62ec945bc47236db60277eb9bee8c7421a023b049a600df7674dd07e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antiviral agents</topic><topic>Biological and medical sciences</topic><topic>Drug dosages</topic><topic>Drug resistance</topic><topic>Households</topic><topic>Influenza virus</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>zanamivir</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hayden, Frederick G</creatorcontrib><creatorcontrib>Gubareva, Larisa V</creatorcontrib><creatorcontrib>Monto, Arnold S</creatorcontrib><creatorcontrib>Klein, Thomas C</creatorcontrib><creatorcontrib>Elliott, Michael J</creatorcontrib><creatorcontrib>Hammond, Janet M</creatorcontrib><creatorcontrib>Sharp, Stephen J</creatorcontrib><creatorcontrib>Ossi, Michael J</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>Biological Sciences</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>PML(ProQuest Medical Library)</collection><collection>Psychology Database</collection><collection>ProQuest Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hayden, Frederick G</au><au>Gubareva, Larisa V</au><au>Monto, Arnold S</au><au>Klein, Thomas C</au><au>Elliott, Michael J</au><au>Hammond, Janet M</au><au>Sharp, Stephen J</au><au>Ossi, Michael J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhaled Zanamivir for the Prevention of Influenza in Families</atitle><jtitle>The New England journal of medicine</jtitle><date>2000-11-02</date><risdate>2000</risdate><volume>343</volume><issue>18</issue><spage>1282</spage><epage>1289</epage><pages>1282-1289</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>Influenzaviruses are frequently transmitted within households. In some epidemics, up to 50 percent of households have one or more members who become infected. The average secondary attack rates among family members is 25 percent,
1
although family composition, the circulating viral strain, and the presence or absence of exposure outside the household
2
influence the likelihood of secondary cases.
Amantadine and rimantadine selectively inhibit the ion-channel function of the M2 protein of influenza A viruses.
3
These drugs have been used for postexposure prophylaxis in households, with reductions in influenza among family members (household contacts) of the index patient ranging from 3 to . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><doi>10.1056/NEJM200011023431801</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2000-11, Vol.343 (18), p.1282-1289 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_17737750 |
| source | EZB Electronic Journals Library; New England Journal of Medicine |
| subjects | Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Drug dosages Drug resistance Households Influenza virus Medical sciences Pharmacology. Drug treatments zanamivir |
| title | Inhaled Zanamivir for the Prevention of Influenza in Families |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T07%3A38%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Inhaled%20Zanamivir%20for%20the%20Prevention%20of%20Influenza%20in%20Families&rft.jtitle=The%20New%20England%20journal%20of%20medicine&rft.au=Hayden,%20Frederick%20G&rft.date=2000-11-02&rft.volume=343&rft.issue=18&rft.spage=1282&rft.epage=1289&rft.pages=1282-1289&rft.issn=0028-4793&rft.eissn=1533-4406&rft.coden=NEJMAG&rft_id=info:doi/10.1056/NEJM200011023431801&rft_dat=%3Cproquest_cross%3E63053541%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=223950499&rft_id=info:pmid/&rfr_iscdi=true |