Once-Daily versus Twice-Daily Lamivudine, in Combination with Zidovudine and Efavirenz, for the Treatment of Antiretroviral-Naive Adults with HIV Infection: A Randomized Equivalence Trial

A randomized, double-blind, double-dummy controlled, multicenter trial was conducted that involved 554 antiretroviral-naive human immunodeficiency virus—infected adults (plasma HIV type 1 [HIV-1] RNA level, ⩾400 copies/mL; CD4+ cell count, >100 cells/mm3) and compared a 300-mg once-daily (q.d.) r...

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Veröffentlicht in:	Clinical infectious diseases 2004-08, Vol.39 (3), p.411-418
Hauptverfasser:	DeJesus, Edwin, McCarty, Debra, Farthing, Charles F., Shortino, Denise D., Grinsztejn, Beatriz, Thomas, Deborah A., Schrader, Shannon R., Castillo, Steve A., Sension, Michael G., Gough, Kevin, Madison, Sam J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged AIDS Anti-HIV Agents - administration & dosage Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretroviral Therapy, Highly Active - methods Antiretrovirals Antiviral agents Antivirals Benzoxazines Biological and medical sciences CD4 Lymphocyte Count Disease Progression Double-Blind Method Drug Administration Schedule Drug Resistance, Viral Female General aspects HIV HIV 1 HIV infections HIV Infections - drug therapy HIV Infections - virology HIV-1 - drug effects HIV-1 - isolation & purification HIV/AIDS Human immunodeficiency virus 1 Human viral diseases Humans Infectious diseases Lamivudine - administration & dosage Lamivudine - adverse effects Male Medical sciences Middle Aged Oxazines - administration & dosage Pharmacology. Drug treatments Reverse Transcriptase Inhibitors - administration & dosage Reverse Transcriptase Inhibitors - adverse effects RNA RNA, Viral - blood Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load Virology Viruses Zidovudine - administration & dosage
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