The Species-Dependent Metabolism of Efavirenz Produces a Nephrotoxic Glutathione Conjugate in Rats

Efavirenz, a potent nonnucleoside reverse transcriptase inhibitor widely prescribed for the treatment of HIV infection, produces renal tubular epithelial cell necrosis in rats but not in cynomolgus monkeys or humans. This species selectivity in nephrotoxicity could result from differences in the pro...

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Veröffentlicht in:	Toxicology and applied pharmacology 2000-11, Vol.169 (1), p.102-113
Hauptverfasser:	Mutlib, Abdul E., Gerson, Ronald J., Meunier, Paul C., Haley, Patrick J., Chen, Hao, Gan, Lawrence S., Davies, Marc H., Gemzik, Brian, Christ, David D., Krahn, David F., Markwalder, Jay A., Seitz, Steven P., Robertson, Richard T., Miwa, Gerald T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-HIV Agents - metabolism Benzoxazines Biological and medical sciences Drug toxicity and drugs side effects treatment efavirenz Enzyme Inhibitors - pharmacology Epithelial Cells - drug effects Epithelial Cells - pathology Gas Chromatography-Mass Spectrometry Glutathione - drug effects Glutathione - metabolism glutathione adduct Haplorhini Human immunodeficiency virus Humans Isoxazoles - pharmacology Kidney Diseases - chemically induced Kidney Diseases - metabolism Kidney Tubules - drug effects Kidney Tubules - pathology Male Medical sciences Necrosis nephrotoxicity Oxazines - metabolism Oxazines - toxicity Pharmacology. Drug treatments Rats Rats, Sprague-Dawley reactive metabolites Reverse Transcriptase Inhibitors - metabolism Reverse Transcriptase Inhibitors - toxicity Species Specificity Toxicity: urogenital system
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