Co-milling of telmisartan with poly(vinyl alcohol) – An alkalinizer free green approach to ensure its bioavailability

[Display omitted] •Telmisartan and poly(vinyl alcohol) were co-milled in a planetary micro mill.•The size and physical state of the telmisartan particles were depended on process parameters used.•Dissolution of telmisartan from CG1 tablet was 96.57±2.02% at 30min.•Bioavailability of CG 1 tablet (93....

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Veröffentlicht in:	European journal of pharmaceutics and biopharmaceutics 2016-04, Vol.101, p.43-52
Hauptverfasser:	Isaac, Jinu, Ganguly, Swastika, Ghosh, Animesh
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzimidazoles - chemistry Benzimidazoles - pharmacokinetics Benzoates - chemistry Benzoates - pharmacokinetics Biological Availability Calorimetry, Differential Scanning - methods Co-milling Disordered crystals Drug Compounding - methods Green pharmaceutical formulation Microscopy, Electron, Scanning - methods Particle Size Poly(vinyl alcohol) Polymers - chemistry Polyvinyl Chloride - chemistry Powders - chemistry Rabbits Solubility Tablets - chemistry Tablets - pharmacokinetics Telmisartan X-Ray Diffraction - methods
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