Dissemination of the mcr-1 colistin resistance gene
Since our first report on plasmid-mediated colistin resistance gene mcr-1,1 strains previously collected in seven countries (Denmark, the Netherlands, Laos, Nigeria, Thailand, France, and the UK) have been found to carry mcr-1.2-6 Furthermore, the sequences in GenBank show that mcr-1 might also be c...
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| Veröffentlicht in: | The Lancet infectious diseases 2016-03, Vol.16 (3), p.292-293 |
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| container_title | The Lancet infectious diseases |
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| creator | Zhi, Chanping Lv, Luchao Yu, Lin-Feng Doi, Yohei Liu, Jian-Hua |
| description | Since our first report on plasmid-mediated colistin resistance gene mcr-1,1 strains previously collected in seven countries (Denmark, the Netherlands, Laos, Nigeria, Thailand, France, and the UK) have been found to carry mcr-1.2-6 Furthermore, the sequences in GenBank show that mcr-1 might also be circulating in Portugal and Malaysia. Interestingly, the sequence of pHNSHP45-2 is also almost identical to the partial sequence of a salmonalla Sal25 plasmid (GenBank accession number LFCC01000022) carrying mcr-1 from a food sample in Portugal. [...]IncHI2 plasmids carrying mcr-1 seem to have spread among different Enterobacteriaceae species and continents, which further suggests that food plays an important part in the spread of mcr-1 worldwide. |
| doi_str_mv | 10.1016/S1473-3099(16)00063-3 |
| format | Article |
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Interestingly, the sequence of pHNSHP45-2 is also almost identical to the partial sequence of a salmonalla Sal25 plasmid (GenBank accession number LFCC01000022) carrying mcr-1 from a food sample in Portugal. 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Interestingly, the sequence of pHNSHP45-2 is also almost identical to the partial sequence of a salmonalla Sal25 plasmid (GenBank accession number LFCC01000022) carrying mcr-1 from a food sample in Portugal. 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| subjects | Animals Antibiotics Colistin - therapeutic use Enterobacteriaceae - drug effects Enterobacteriaceae Infections - drug therapy Enterobacteriaceae Infections - immunology Genes Humans Infectious Disease Infectious diseases Plasmids Plasmids - immunology Polymyxins - therapeutic use Swine Diseases - drug therapy |
| title | Dissemination of the mcr-1 colistin resistance gene |
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