Clinical value of capsule endoscopy for detecting small bowel lesions in patients with intestinal Behçet's disease
Background and Aim To evaluate the clinical value of capsule endoscopy (CE) in patients with intestinal Behçet's disease (BD). Methods The present study was a case–control pilot study conducted in intestinal BD patients and healthy volunteers. A total of 19 patients with intestinal BD (intestin...
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| Veröffentlicht in: | Digestive endoscopy 2016-03, Vol.28 (2), p.179-185 |
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| creator | Arimoto, Jun Endo, Hiroki Kato, Takayuki Umezawa, Shotaro Fuyuki, Akiko Uchiyama, Shiori Higurashi, Takuma Ohkubo, Hidenori Nonaka, Takashi Takeno, Mitsuhiro Ishigatsubo, Yoshiaki Sakai, Eiji Matsuhashi, Nobuyuki Nakajima, Atsushi |
| description | Background and Aim
To evaluate the clinical value of capsule endoscopy (CE) in patients with intestinal Behçet's disease (BD).
Methods
The present study was a case–control pilot study conducted in intestinal BD patients and healthy volunteers. A total of 19 patients with intestinal BD (intestinal BD group) and 19 healthy volunteers (control group) matched for age and sex were enrolled. Frequency, number of small bowel lesions per subject, and Lewis score were comparatively evaluated between the two groups.
Results
Of the 19 patients with intestinal BD, 18 (94.7%) had reddened lesions, 15 (78.9%) had erosions, and nine (47.4%) had ulcers. There were significant differences in the frequency of reddened lesions (P |
| doi_str_mv | 10.1111/den.12552 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1773425720</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1773425720</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3872-c703e0f3f41b113e846213a88004bcbfa0ad525e6d135e08c7137254e60ba8723</originalsourceid><addsrcrecordid>eNp1kM9OFEEQhztEAit68AVM38TDQP-dnj3qgkCCGBMMxkunp6cGGnunx6kZl30iH8QXo2WBm3WppPL9vlR-hLzh7IDnOWygO-BCa7FFZlwpWfCy5C_IjM25LnQp9S55iXjLGBdzpXbIriiVns-5mRFcxNAF7yL97eIENLXUux6nCBS6JqFP_Zq2aaANjODH0F1TXLoYaZ1WEGkEDKlDGjrauzFANyJdhfEmH0bAjGfxR7j5-wfGd0ibgOAQXpHt1kWE1497j3z7dHy5OC3Ov5ycLT6cF15WRhTeMAmsla3iNecSKlUKLl1VMaZqX7eOuUYLDWXDpQZWecOlEVpByWqXBXKP7G-8_ZB-TfkduwzoIUbXQZrQcmOkEtoIltH3G9QPCXGA1vZDWLphbTmz_zq2uWP70HFm3z5qp3oJzTP5VGoGDjfAKkRY_99kj44vnpTFJhFwhLvnhBt-2tJIo-3VxYn9-uO7vFywK_tZ3gNwBpZX</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1773425720</pqid></control><display><type>article</type><title>Clinical value of capsule endoscopy for detecting small bowel lesions in patients with intestinal Behçet's disease</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Arimoto, Jun ; Endo, Hiroki ; Kato, Takayuki ; Umezawa, Shotaro ; Fuyuki, Akiko ; Uchiyama, Shiori ; Higurashi, Takuma ; Ohkubo, Hidenori ; Nonaka, Takashi ; Takeno, Mitsuhiro ; Ishigatsubo, Yoshiaki ; Sakai, Eiji ; Matsuhashi, Nobuyuki ; Nakajima, Atsushi</creator><creatorcontrib>Arimoto, Jun ; Endo, Hiroki ; Kato, Takayuki ; Umezawa, Shotaro ; Fuyuki, Akiko ; Uchiyama, Shiori ; Higurashi, Takuma ; Ohkubo, Hidenori ; Nonaka, Takashi ; Takeno, Mitsuhiro ; Ishigatsubo, Yoshiaki ; Sakai, Eiji ; Matsuhashi, Nobuyuki ; Nakajima, Atsushi</creatorcontrib><description>Background and Aim
To evaluate the clinical value of capsule endoscopy (CE) in patients with intestinal Behçet's disease (BD).
Methods
The present study was a case–control pilot study conducted in intestinal BD patients and healthy volunteers. A total of 19 patients with intestinal BD (intestinal BD group) and 19 healthy volunteers (control group) matched for age and sex were enrolled. Frequency, number of small bowel lesions per subject, and Lewis score were comparatively evaluated between the two groups.
Results
Of the 19 patients with intestinal BD, 18 (94.7%) had reddened lesions, 15 (78.9%) had erosions, and nine (47.4%) had ulcers. There were significant differences in the frequency of reddened lesions (P < 0.0001), erosions (P < 0.0001) and ulcers (P = 0.0011) between the two groups. The difference in the number of small bowel lesions between the two groups was also statistically significant. The median Lewis score in the intestinal BD group was significantly higher than that in the control group (intestinal BD group 237 (0–768) vs control group 8 (0–135); P < 0.0001). Analysis according to the location in the small bowel revealed that the frequency of ulcers tended to increase towards the distal intestine.
Conclusion
This is the first CE study conducted to examine small bowel involvement in intestinal BD patients. Our results suggest that CE evaluation is necessary, in addition to colonoscopy, in all intestinal BD patients.</description><identifier>ISSN: 0915-5635</identifier><identifier>EISSN: 1443-1661</identifier><identifier>DOI: 10.1111/den.12552</identifier><identifier>PMID: 26459917</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>Adult ; Behcet Syndrome - complications ; Behcet Syndrome - diagnosis ; capsule endoscopy ; Capsule Endoscopy - methods ; Case-Control Studies ; disease activity index for intestinal Behçet's disease ; Female ; Follow-Up Studies ; Humans ; intestinal Behçet's disease ; Intestinal Diseases - diagnosis ; Intestinal Diseases - etiology ; Intestinal Mucosa - diagnostic imaging ; Intestine, Small - diagnostic imaging ; lewis score ; Male ; Pilot Projects ; Reproducibility of Results ; Retrospective Studies ; small bowel lesion ; Time Factors</subject><ispartof>Digestive endoscopy, 2016-03, Vol.28 (2), p.179-185</ispartof><rights>2015 Japan Gastroenterological Endoscopy Society</rights><rights>2015 Japan Gastroenterological Endoscopy Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3872-c703e0f3f41b113e846213a88004bcbfa0ad525e6d135e08c7137254e60ba8723</citedby><cites>FETCH-LOGICAL-c3872-c703e0f3f41b113e846213a88004bcbfa0ad525e6d135e08c7137254e60ba8723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fden.12552$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fden.12552$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27911,27912,45561,45562</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26459917$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arimoto, Jun</creatorcontrib><creatorcontrib>Endo, Hiroki</creatorcontrib><creatorcontrib>Kato, Takayuki</creatorcontrib><creatorcontrib>Umezawa, Shotaro</creatorcontrib><creatorcontrib>Fuyuki, Akiko</creatorcontrib><creatorcontrib>Uchiyama, Shiori</creatorcontrib><creatorcontrib>Higurashi, Takuma</creatorcontrib><creatorcontrib>Ohkubo, Hidenori</creatorcontrib><creatorcontrib>Nonaka, Takashi</creatorcontrib><creatorcontrib>Takeno, Mitsuhiro</creatorcontrib><creatorcontrib>Ishigatsubo, Yoshiaki</creatorcontrib><creatorcontrib>Sakai, Eiji</creatorcontrib><creatorcontrib>Matsuhashi, Nobuyuki</creatorcontrib><creatorcontrib>Nakajima, Atsushi</creatorcontrib><title>Clinical value of capsule endoscopy for detecting small bowel lesions in patients with intestinal Behçet's disease</title><title>Digestive endoscopy</title><addtitle>Digestive Endoscopy</addtitle><description>Background and Aim
To evaluate the clinical value of capsule endoscopy (CE) in patients with intestinal Behçet's disease (BD).
Methods
The present study was a case–control pilot study conducted in intestinal BD patients and healthy volunteers. A total of 19 patients with intestinal BD (intestinal BD group) and 19 healthy volunteers (control group) matched for age and sex were enrolled. Frequency, number of small bowel lesions per subject, and Lewis score were comparatively evaluated between the two groups.
Results
Of the 19 patients with intestinal BD, 18 (94.7%) had reddened lesions, 15 (78.9%) had erosions, and nine (47.4%) had ulcers. There were significant differences in the frequency of reddened lesions (P < 0.0001), erosions (P < 0.0001) and ulcers (P = 0.0011) between the two groups. The difference in the number of small bowel lesions between the two groups was also statistically significant. The median Lewis score in the intestinal BD group was significantly higher than that in the control group (intestinal BD group 237 (0–768) vs control group 8 (0–135); P < 0.0001). Analysis according to the location in the small bowel revealed that the frequency of ulcers tended to increase towards the distal intestine.
Conclusion
This is the first CE study conducted to examine small bowel involvement in intestinal BD patients. Our results suggest that CE evaluation is necessary, in addition to colonoscopy, in all intestinal BD patients.</description><subject>Adult</subject><subject>Behcet Syndrome - complications</subject><subject>Behcet Syndrome - diagnosis</subject><subject>capsule endoscopy</subject><subject>Capsule Endoscopy - methods</subject><subject>Case-Control Studies</subject><subject>disease activity index for intestinal Behçet's disease</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>intestinal Behçet's disease</subject><subject>Intestinal Diseases - diagnosis</subject><subject>Intestinal Diseases - etiology</subject><subject>Intestinal Mucosa - diagnostic imaging</subject><subject>Intestine, Small - diagnostic imaging</subject><subject>lewis score</subject><subject>Male</subject><subject>Pilot Projects</subject><subject>Reproducibility of Results</subject><subject>Retrospective Studies</subject><subject>small bowel lesion</subject><subject>Time Factors</subject><issn>0915-5635</issn><issn>1443-1661</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM9OFEEQhztEAit68AVM38TDQP-dnj3qgkCCGBMMxkunp6cGGnunx6kZl30iH8QXo2WBm3WppPL9vlR-hLzh7IDnOWygO-BCa7FFZlwpWfCy5C_IjM25LnQp9S55iXjLGBdzpXbIriiVns-5mRFcxNAF7yL97eIENLXUux6nCBS6JqFP_Zq2aaANjODH0F1TXLoYaZ1WEGkEDKlDGjrauzFANyJdhfEmH0bAjGfxR7j5-wfGd0ibgOAQXpHt1kWE1497j3z7dHy5OC3Ov5ycLT6cF15WRhTeMAmsla3iNecSKlUKLl1VMaZqX7eOuUYLDWXDpQZWecOlEVpByWqXBXKP7G-8_ZB-TfkduwzoIUbXQZrQcmOkEtoIltH3G9QPCXGA1vZDWLphbTmz_zq2uWP70HFm3z5qp3oJzTP5VGoGDjfAKkRY_99kj44vnpTFJhFwhLvnhBt-2tJIo-3VxYn9-uO7vFywK_tZ3gNwBpZX</recordid><startdate>201603</startdate><enddate>201603</enddate><creator>Arimoto, Jun</creator><creator>Endo, Hiroki</creator><creator>Kato, Takayuki</creator><creator>Umezawa, Shotaro</creator><creator>Fuyuki, Akiko</creator><creator>Uchiyama, Shiori</creator><creator>Higurashi, Takuma</creator><creator>Ohkubo, Hidenori</creator><creator>Nonaka, Takashi</creator><creator>Takeno, Mitsuhiro</creator><creator>Ishigatsubo, Yoshiaki</creator><creator>Sakai, Eiji</creator><creator>Matsuhashi, Nobuyuki</creator><creator>Nakajima, Atsushi</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201603</creationdate><title>Clinical value of capsule endoscopy for detecting small bowel lesions in patients with intestinal Behçet's disease</title><author>Arimoto, Jun ; Endo, Hiroki ; Kato, Takayuki ; Umezawa, Shotaro ; Fuyuki, Akiko ; Uchiyama, Shiori ; Higurashi, Takuma ; Ohkubo, Hidenori ; Nonaka, Takashi ; Takeno, Mitsuhiro ; Ishigatsubo, Yoshiaki ; Sakai, Eiji ; Matsuhashi, Nobuyuki ; Nakajima, Atsushi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3872-c703e0f3f41b113e846213a88004bcbfa0ad525e6d135e08c7137254e60ba8723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Behcet Syndrome - complications</topic><topic>Behcet Syndrome - diagnosis</topic><topic>capsule endoscopy</topic><topic>Capsule Endoscopy - methods</topic><topic>Case-Control Studies</topic><topic>disease activity index for intestinal Behçet's disease</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>intestinal Behçet's disease</topic><topic>Intestinal Diseases - diagnosis</topic><topic>Intestinal Diseases - etiology</topic><topic>Intestinal Mucosa - diagnostic imaging</topic><topic>Intestine, Small - diagnostic imaging</topic><topic>lewis score</topic><topic>Male</topic><topic>Pilot Projects</topic><topic>Reproducibility of Results</topic><topic>Retrospective Studies</topic><topic>small bowel lesion</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arimoto, Jun</creatorcontrib><creatorcontrib>Endo, Hiroki</creatorcontrib><creatorcontrib>Kato, Takayuki</creatorcontrib><creatorcontrib>Umezawa, Shotaro</creatorcontrib><creatorcontrib>Fuyuki, Akiko</creatorcontrib><creatorcontrib>Uchiyama, Shiori</creatorcontrib><creatorcontrib>Higurashi, Takuma</creatorcontrib><creatorcontrib>Ohkubo, Hidenori</creatorcontrib><creatorcontrib>Nonaka, Takashi</creatorcontrib><creatorcontrib>Takeno, Mitsuhiro</creatorcontrib><creatorcontrib>Ishigatsubo, Yoshiaki</creatorcontrib><creatorcontrib>Sakai, Eiji</creatorcontrib><creatorcontrib>Matsuhashi, Nobuyuki</creatorcontrib><creatorcontrib>Nakajima, Atsushi</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive endoscopy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arimoto, Jun</au><au>Endo, Hiroki</au><au>Kato, Takayuki</au><au>Umezawa, Shotaro</au><au>Fuyuki, Akiko</au><au>Uchiyama, Shiori</au><au>Higurashi, Takuma</au><au>Ohkubo, Hidenori</au><au>Nonaka, Takashi</au><au>Takeno, Mitsuhiro</au><au>Ishigatsubo, Yoshiaki</au><au>Sakai, Eiji</au><au>Matsuhashi, Nobuyuki</au><au>Nakajima, Atsushi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical value of capsule endoscopy for detecting small bowel lesions in patients with intestinal Behçet's disease</atitle><jtitle>Digestive endoscopy</jtitle><addtitle>Digestive Endoscopy</addtitle><date>2016-03</date><risdate>2016</risdate><volume>28</volume><issue>2</issue><spage>179</spage><epage>185</epage><pages>179-185</pages><issn>0915-5635</issn><eissn>1443-1661</eissn><abstract>Background and Aim
To evaluate the clinical value of capsule endoscopy (CE) in patients with intestinal Behçet's disease (BD).
Methods
The present study was a case–control pilot study conducted in intestinal BD patients and healthy volunteers. A total of 19 patients with intestinal BD (intestinal BD group) and 19 healthy volunteers (control group) matched for age and sex were enrolled. Frequency, number of small bowel lesions per subject, and Lewis score were comparatively evaluated between the two groups.
Results
Of the 19 patients with intestinal BD, 18 (94.7%) had reddened lesions, 15 (78.9%) had erosions, and nine (47.4%) had ulcers. There were significant differences in the frequency of reddened lesions (P < 0.0001), erosions (P < 0.0001) and ulcers (P = 0.0011) between the two groups. The difference in the number of small bowel lesions between the two groups was also statistically significant. The median Lewis score in the intestinal BD group was significantly higher than that in the control group (intestinal BD group 237 (0–768) vs control group 8 (0–135); P < 0.0001). Analysis according to the location in the small bowel revealed that the frequency of ulcers tended to increase towards the distal intestine.
Conclusion
This is the first CE study conducted to examine small bowel involvement in intestinal BD patients. Our results suggest that CE evaluation is necessary, in addition to colonoscopy, in all intestinal BD patients.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>26459917</pmid><doi>10.1111/den.12552</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Behcet Syndrome - complications Behcet Syndrome - diagnosis capsule endoscopy Capsule Endoscopy - methods Case-Control Studies disease activity index for intestinal Behçet's disease Female Follow-Up Studies Humans intestinal Behçet's disease Intestinal Diseases - diagnosis Intestinal Diseases - etiology Intestinal Mucosa - diagnostic imaging Intestine, Small - diagnostic imaging lewis score Male Pilot Projects Reproducibility of Results Retrospective Studies small bowel lesion Time Factors |
| title | Clinical value of capsule endoscopy for detecting small bowel lesions in patients with intestinal Behçet's disease |
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