Effect of normal-fat diets, either medium or high in protein, on body weight in overweight subjects: a randomised 1-year trial

We have previously reported that a fat-reduced high-protein diet had more favourable effects on body weight loss over 6 months than a medium-protein diet. To extend this observation by a further 6-12 months less stringent intervention and a 24 months follow-up. A randomised 6 months strictly controlled dietary intervention followed by 6-12 months dietary counselling period, and a subsequent 24 months follow-up, comparing an ad libitum, fat-reduced diet (30% of energy) either high in protein (25% of energy, HP) or medium in protein (12% of energy, MP). A total of 50 overweight and obese subjects (age: 19-55 y; BMI: 26-34 kg/m(2)). Change in body weight, body composition and blood parameters. After 6 months, the HP group (n=23) achieved a greater weight loss than the MP group (n=23) (9.4 vs 5.9 kg) (P