Runx2 Is a Common Target of Transforming Growth Factor beta 1 and Bone Morphogenetic Protein 2, and Cooperation between Runx2 and Smad5 Induces Osteoblast-Specific Gene Expression in the Pluripotent Mesenchymal Precursor Cell Line C2C12

When C2C12 pluripotent mesenchymal precursor cells are treated with transforming growth factor beta 1 (TGF- beta 1), terminal differentiation into myotubes is blocked. Treatment with bone morphogenetic protein 2 (BMP-2) not only blocks myogenic differentiation of C2C12 cells but also induces osteobl...

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Veröffentlicht in:	Molecular and cellular biology 2000-12, Vol.20 (23), p.8783-8792
Hauptverfasser:	Lee, K, Kim, H, Li, Q, Chi, X, Ueta, C, Komori, T, Wozney, J M, Kim, E, Choi, J, Ryoo, H, Bae, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Cbfa1 protein PEBP2 protein Runx2 protein Smad5 protein
Online-Zugang:	Volltext
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