The androgen receptor CAG repeat: a modifier of carcinogenesis?

The first exon of the human androgen receptor (AR) contains a translated CAG (poly-glutamine) repeat. The repeat length is polymorphic in the normal population ranging from 8 to 35 repeats. Expansions to over 40 repeats lead to spinal bulbar muscular atrophy (SBMA), a late onset neurodegenerative di...

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Veröffentlicht in:	Molecular and cellular endocrinology 2002-07, Vol.193 (1), p.109-120
Hauptverfasser:	Ferro, Paola, Catalano, Maria G., Dell'Eva, Raffaella, Fortunati, Nicoletta, Pfeffer, Ulrich
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgen receptor Breast Neoplasms - etiology Breast Neoplasms - genetics CAG repeat Colon cancer Colonic Neoplasms - etiology Colonic Neoplasms - genetics Endometrial Neoplasms - etiology Endometrial Neoplasms - genetics Female Humans Kennedy's disease Low penetrance susceptibility gene Male Microsatellite instability Neoplasms - etiology Neoplasms - genetics Polymorphism, Genetic Prostatic Neoplasms - etiology Prostatic Neoplasms - genetics Receptors, Androgen - genetics Somatic mutation Trinucleotide Repeats - physiology
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