Phosphoinositide 3-Kinase Induces the Transcriptional Activity of MEF2 Proteins during Muscle Differentiation

The activity of phosphoinositide 3-kinase (PI3-K) is essential for the differentiation of skeletal muscle cells by largely unknown mechanisms. Here we show that inhibition of PI3-K activity by the pharmacological agent LY294002 affects early processes of myoblast differentiation including the transc...

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Veröffentlicht in:	The Journal of biological chemistry 2000-11, Vol.275 (44), p.34424-34432
Hauptverfasser:	Tamir, Yael, Bengal, Eyal
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Cell Differentiation - physiology Cell Line DNA Probes DNA-Binding Proteins - physiology Enzyme Inhibitors - pharmacology Gene Expression Regulation, Developmental - drug effects Gene Expression Regulation, Developmental - physiology LY294002 MEF2 protein MEF2 Transcription Factors Muscle Development Muscle, Skeletal - cytology Muscle, Skeletal - growth & development MyoD protein Myogenic Regulatory Factors Myogenin - genetics Phosphatidylinositol 3-Kinases - physiology phosphoinositide 3-kinase Phosphoinositide-3 Kinase Inhibitors Transcription Factors - physiology Transcription, Genetic - drug effects Transcription, Genetic - physiology
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