Locked Nucleic Acid: A Potent Nucleic Acid Analog in Therapeutics and Biotechnology

Locked nucleic acid (LNA) is a class of nucleic acid analogs possessing very high affinity and excellent specificity toward complementary DNA and RNA, and LNA oligonucleotides have been applied as antisense molecules both in vitro and in vivo . In this review, we briefly describe the basic physioche...

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