Dopamine D1 Receptor Agonist A-68930 Inhibits NLRP3 Inflammasome Activation, Controls Inflammation, and Alleviates Histopathology in a Rat Model of Spinal Cord Injury

STUDY DESIGN.A randomized experimental study. OBJECTIVE.The aim of this study was to investigate the therapeutic efficacy and molecular mechanisms of dopamine D1 receptor agonist A-68930 in spinal cord injury (SCI) rats. SUMMARY OF BACKGROUND DATA.The inflammation induced by SCI includes maturation...

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Veröffentlicht in:	Spine (Philadelphia, Pa. 1976) Pa. 1976), 2016-03, Vol.41 (6), p.E330-E334
Hauptverfasser:	Jiang, Wu, Huang, Yan, He, Fan, Liu, Jia, Li, Maoqiang, Sun, Tiansheng, Ren, Wencheng, Hou, Jingming, Zhu, Liulong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chromans - pharmacology Chromans - therapeutic use Cytokines - metabolism Female Histocytochemistry Inflammasomes - drug effects Inflammation - metabolism Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Rats Rats, Sprague-Dawley Receptors, Dopamine D1 - agonists Spinal Cord - drug effects Spinal Cord - metabolism Spinal Cord - pathology Spinal Cord Injuries - drug therapy Spinal Cord Injuries - metabolism Spinal Cord Injuries - pathology
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