Reduction in Late Mortality among 5-Year Survivors of Childhood Cancer
Alterations in treatment intensity and decreased use of radiation therapy have reduced the risk of late treatment-related death in long-term survivors of childhood cancer. In the 1960s, fewer than half the children in whom cancer was diagnosed were still alive 5 years later. 1 Now, more than 83% of...
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| Veröffentlicht in: | The New England journal of medicine 2016-03, Vol.374 (9), p.833-842 |
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| container_title | The New England journal of medicine |
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| creator | Armstrong, Gregory T Chen, Yan Yasui, Yutaka Leisenring, Wendy Gibson, Todd M Mertens, Ann C Stovall, Marilyn Oeffinger, Kevin C Bhatia, Smita Krull, Kevin R Nathan, Paul C Neglia, Joseph P Green, Daniel M Hudson, Melissa M Robison, Leslie L |
| description | Alterations in treatment intensity and decreased use of radiation therapy have reduced the risk of late treatment-related death in long-term survivors of childhood cancer.
In the 1960s, fewer than half the children in whom cancer was diagnosed were still alive 5 years later.
1
Now, more than 83% of patients with a childhood cancer in the United States become 5-year survivors of the disease.
2
As a result, in 2013 it was estimated that there were more than 420,000 survivors of childhood cancer in the United States and that by the year 2020 this number would surpass 500,000.
3
Increased success in the treatment of childhood cancers has been achieved through the systematic conduct of clinical trials to assess the efficacy of multimodal approaches involving combination chemotherapy, . . . |
| doi_str_mv | 10.1056/NEJMoa1510795 |
| format | Article |
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In the 1960s, fewer than half the children in whom cancer was diagnosed were still alive 5 years later.
1
Now, more than 83% of patients with a childhood cancer in the United States become 5-year survivors of the disease.
2
As a result, in 2013 it was estimated that there were more than 420,000 survivors of childhood cancer in the United States and that by the year 2020 this number would surpass 500,000.
3
Increased success in the treatment of childhood cancers has been achieved through the systematic conduct of clinical trials to assess the efficacy of multimodal approaches involving combination chemotherapy, . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa1510795</identifier><identifier>PMID: 26761625</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Acute lymphoblastic leukemia ; Adolescent ; Age of Onset ; Anthracycline ; Astrocytoma - mortality ; Cancer ; Cancer therapies ; Child ; Child mortality ; Child, Preschool ; Children ; Children & youth ; Clinical outcomes ; Cohort Studies ; Death ; Disease Progression ; Female ; Health risk assessment ; Heart ; Hodgkin Disease - mortality ; Humans ; Incidence ; Infant ; Lymphatic leukemia ; Lymphoma ; Male ; Mortality ; Mortality - trends ; Neoplasms - mortality ; Neoplasms - therapy ; Patients ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality ; Radiation therapy ; Recurrence ; Survivors ; United States - epidemiology ; Wilms Tumor - mortality</subject><ispartof>The New England journal of medicine, 2016-03, Vol.374 (9), p.833-842</ispartof><rights>Copyright © 2016 Massachusetts Medical Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-a77a55ee9be39dbed40627f493b1683e193468b63af38679de8ba6c753b420373</citedby><cites>FETCH-LOGICAL-c456t-a77a55ee9be39dbed40627f493b1683e193468b63af38679de8ba6c753b420373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa1510795$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1770399029?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>315,782,786,2763,2764,26112,27933,27934,52391,54073,64394,64396,64398,72478</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26761625$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Armstrong, Gregory T</creatorcontrib><creatorcontrib>Chen, Yan</creatorcontrib><creatorcontrib>Yasui, Yutaka</creatorcontrib><creatorcontrib>Leisenring, Wendy</creatorcontrib><creatorcontrib>Gibson, Todd M</creatorcontrib><creatorcontrib>Mertens, Ann C</creatorcontrib><creatorcontrib>Stovall, Marilyn</creatorcontrib><creatorcontrib>Oeffinger, Kevin C</creatorcontrib><creatorcontrib>Bhatia, Smita</creatorcontrib><creatorcontrib>Krull, Kevin R</creatorcontrib><creatorcontrib>Nathan, Paul C</creatorcontrib><creatorcontrib>Neglia, Joseph P</creatorcontrib><creatorcontrib>Green, Daniel M</creatorcontrib><creatorcontrib>Hudson, Melissa M</creatorcontrib><creatorcontrib>Robison, Leslie L</creatorcontrib><title>Reduction in Late Mortality among 5-Year Survivors of Childhood Cancer</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Alterations in treatment intensity and decreased use of radiation therapy have reduced the risk of late treatment-related death in long-term survivors of childhood cancer.
In the 1960s, fewer than half the children in whom cancer was diagnosed were still alive 5 years later.
1
Now, more than 83% of patients with a childhood cancer in the United States become 5-year survivors of the disease.
2
As a result, in 2013 it was estimated that there were more than 420,000 survivors of childhood cancer in the United States and that by the year 2020 this number would surpass 500,000.
3
Increased success in the treatment of childhood cancers has been achieved through the systematic conduct of clinical trials to assess the efficacy of multimodal approaches involving combination chemotherapy, . . .</description><subject>Acute lymphoblastic leukemia</subject><subject>Adolescent</subject><subject>Age of Onset</subject><subject>Anthracycline</subject><subject>Astrocytoma - mortality</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Child</subject><subject>Child mortality</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Children & youth</subject><subject>Clinical outcomes</subject><subject>Cohort Studies</subject><subject>Death</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Heart</subject><subject>Hodgkin Disease - mortality</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infant</subject><subject>Lymphatic leukemia</subject><subject>Lymphoma</subject><subject>Male</subject><subject>Mortality</subject><subject>Mortality - trends</subject><subject>Neoplasms - mortality</subject><subject>Neoplasms - therapy</subject><subject>Patients</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality</subject><subject>Radiation therapy</subject><subject>Recurrence</subject><subject>Survivors</subject><subject>United States - epidemiology</subject><subject>Wilms Tumor - mortality</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp10EtLw0AUBeBBFFurS7cyIIKb6EzmlVlKaH3QKvhYuAqT5MamJJk6kxT6701pFRS8m7v5OBwOQqeUXFEi5PXj-GFmDRWUKC320JAKxgLOidxHQ0LCKOBKswE68n5B-qNcH6JBKJWkMhRDNHmGvMva0ja4bPDUtIBn1rWmKts1NrVtPrAI3sE4_NK5VbmyzmNb4HheVvnc2hzHpsnAHaODwlQeTnZ_hN4m49f4Lpg-3d7HN9Mg40K2gVHKCAGgU2A6TyHve4aq4JqlVEYMqGZcRqlkpmCRVDqHKDUyU4KlPCRMsRG63OYunf3swLdJXfoMqso0YDufUKXCiFGleU_P_9CF7VzTt9sowrQmoe5VsFWZs947KJKlK2vj1gklyWbg5NfAvT_bpXZpDfmP_l60BxdbUNc-aWBR_xP0Bew-fzM</recordid><startdate>20160303</startdate><enddate>20160303</enddate><creator>Armstrong, Gregory T</creator><creator>Chen, Yan</creator><creator>Yasui, Yutaka</creator><creator>Leisenring, Wendy</creator><creator>Gibson, Todd M</creator><creator>Mertens, Ann C</creator><creator>Stovall, Marilyn</creator><creator>Oeffinger, Kevin C</creator><creator>Bhatia, Smita</creator><creator>Krull, Kevin R</creator><creator>Nathan, Paul C</creator><creator>Neglia, Joseph P</creator><creator>Green, Daniel M</creator><creator>Hudson, Melissa M</creator><creator>Robison, Leslie L</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20160303</creationdate><title>Reduction in Late Mortality among 5-Year Survivors of Childhood Cancer</title><author>Armstrong, Gregory T ; Chen, Yan ; Yasui, Yutaka ; Leisenring, Wendy ; Gibson, Todd M ; Mertens, Ann C ; Stovall, Marilyn ; Oeffinger, Kevin C ; Bhatia, Smita ; Krull, Kevin R ; Nathan, Paul C ; Neglia, Joseph P ; Green, Daniel M ; Hudson, Melissa M ; Robison, Leslie L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-a77a55ee9be39dbed40627f493b1683e193468b63af38679de8ba6c753b420373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Acute lymphoblastic leukemia</topic><topic>Adolescent</topic><topic>Age of Onset</topic><topic>Anthracycline</topic><topic>Astrocytoma - 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Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Armstrong, Gregory T</au><au>Chen, Yan</au><au>Yasui, Yutaka</au><au>Leisenring, Wendy</au><au>Gibson, Todd M</au><au>Mertens, Ann C</au><au>Stovall, Marilyn</au><au>Oeffinger, Kevin C</au><au>Bhatia, Smita</au><au>Krull, Kevin R</au><au>Nathan, Paul C</au><au>Neglia, Joseph P</au><au>Green, Daniel M</au><au>Hudson, Melissa M</au><au>Robison, Leslie L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduction in Late Mortality among 5-Year Survivors of Childhood Cancer</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2016-03-03</date><risdate>2016</risdate><volume>374</volume><issue>9</issue><spage>833</spage><epage>842</epage><pages>833-842</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><abstract>Alterations in treatment intensity and decreased use of radiation therapy have reduced the risk of late treatment-related death in long-term survivors of childhood cancer.
In the 1960s, fewer than half the children in whom cancer was diagnosed were still alive 5 years later.
1
Now, more than 83% of patients with a childhood cancer in the United States become 5-year survivors of the disease.
2
As a result, in 2013 it was estimated that there were more than 420,000 survivors of childhood cancer in the United States and that by the year 2020 this number would surpass 500,000.
3
Increased success in the treatment of childhood cancers has been achieved through the systematic conduct of clinical trials to assess the efficacy of multimodal approaches involving combination chemotherapy, . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>26761625</pmid><doi>10.1056/NEJMoa1510795</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The New England journal of medicine, 2016-03, Vol.374 (9), p.833-842 |
| issn | 0028-4793 1533-4406 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Acute lymphoblastic leukemia Adolescent Age of Onset Anthracycline Astrocytoma - mortality Cancer Cancer therapies Child Child mortality Child, Preschool Children Children & youth Clinical outcomes Cohort Studies Death Disease Progression Female Health risk assessment Heart Hodgkin Disease - mortality Humans Incidence Infant Lymphatic leukemia Lymphoma Male Mortality Mortality - trends Neoplasms - mortality Neoplasms - therapy Patients Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality Radiation therapy Recurrence Survivors United States - epidemiology Wilms Tumor - mortality |
| title | Reduction in Late Mortality among 5-Year Survivors of Childhood Cancer |
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