Effects of 2-ethylhexanoic acid on the production of reactive oxygen species in human polymorphonuclear leukocytes in vitro

2-Ethylhexanoic acid (2-EHA), is an industrial chemical and a toxic biotransformation product of the plasticizer di(2-ethylhexyl)phthalate. Its immunological effects are unknown. 2-EHA resembles structurally C18 fatty acids, which are known activators of respiratory burst in human polymorphonuclear...

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Veröffentlicht in:	Toxicology letters 2000-09, Vol.117 (1), p.79-84
Hauptverfasser:	Pennanen, Sirpa M.A, Heiskanen, Kaisa M, Savolainen, Kai M, Komulainen, Hannu
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Ethylhexanoic acid Biological and medical sciences bis(2-ethylhexyl) phthalate Caproates - pharmacology Carcinogenesis, carcinogens and anticarcinogens Cell Survival - drug effects Chemical agents Chemical and industrial products toxicology. Toxic occupational diseases Dose-Response Relationship, Drug Humans Medical sciences N-Formylmethionine Leucyl-Phenylalanine - pharmacology Neutrophils - cytology Neutrophils - drug effects Neutrophils - metabolism Polymorphonuclear leukocytes Protein Kinase C - drug effects Protein Kinase C - metabolism Reactive oxygen species Reactive Oxygen Species - metabolism Tetradecanoylphorbol Acetate - pharmacology Toxicology Tumors Various organic compounds
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