Conjugation of arginine oligomers to cyclosporin A facilitates topical delivery and inhibition of inflammation

Many systemically effective drugs such as cyclosporin A are ineffective topically because of their poor penetration into skin. To surmount this problem, we conjugated a heptamer of arginine to cyclosporin A through a pH-sensitive linker to produce R7-CsA. In contrast to unmodified cyclosporin A, whi...

Ausführliche Beschreibung