Elevated prodynorphin expression associated with ethanol withdrawal convulsions

The hypothesis that κ-opioid system activity may in part mediate convulsions exhibited during ethanol withdrawal was tested by exposing Withdrawal Seizure-Prone (WSP) and Withdrawal Seizure-Resistant (WSR) mice to chronic ethanol. Whole brain was harvested for RNA isolation and prodynorphin mRNA ste...

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Veröffentlicht in:	Neurochemistry international 2000-11, Vol.37 (5), p.463-472
Hauptverfasser:	Beadles-Bohling, A.S., Crabbe, J.C., Wiren, K.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Animals Aversion Convulsions Disease Susceptibility Enkephalins - metabolism Ethanol Ethanol - administration & dosage Ethanol - adverse effects Genetics Glyceraldehyde-3-Phosphate Dehydrogenases - genetics Male Mice Mice, Inbred Strains Prodynorphin Protein Precursors - metabolism RNA, Messenger - metabolism Seizures - chemically induced Seizures - metabolism Selected lines Substance Withdrawal Syndrome - metabolism Withdrawal κ-Opioid receptors
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