MHC, parasites and antler development in red deer: no support for the Hamilton & Zuk hypothesis
The Hamilton‐Zuk hypothesis proposes that the genetic benefits of preferences for elaborated secondary sexual traits have their origins in the arms race between hosts and parasites, which maintains genetic variance in parasite resistance. Infection, in turn, can be reflected in the expression of cos...
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| Veröffentlicht in: | Journal of evolutionary biology 2016-03, Vol.29 (3), p.617-632 |
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| creator | Buczek, M Okarma, H Demiaszkiewicz, A. W Radwan, J |
| description | The Hamilton‐Zuk hypothesis proposes that the genetic benefits of preferences for elaborated secondary sexual traits have their origins in the arms race between hosts and parasites, which maintains genetic variance in parasite resistance. Infection, in turn, can be reflected in the expression of costly sexual ornaments. However, the link between immune genes, infection and the expression of secondary sexual traits has rarely been investigated. Here, we explored whether the presence and identity of functional variants (supertypes) of the highly polymorphic major histocompatibility complex (MHC), which is responsible for the recognition of parasites, predict the load of lung and gut parasites and antler development in the red deer (Cervus elaphus). While we found MHC supertypes to be associated with infection by a number of parasite species, including debilitating lung nematodes, we did not find support for the Hamilton‐Zuk hypothesis. On the contrary, we found that lung nematode load was positively associated with antler development. We also found that the supertypes that were associated with resistance to certain parasites at the same time cause susceptibility to others. Such trade‐offs may undermine the potential genetic benefits of mate choice for resistant partners. |
| doi_str_mv | 10.1111/jeb.12811 |
| format | Article |
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W ; Radwan, J</creator><creatorcontrib>Buczek, M ; Okarma, H ; Demiaszkiewicz, A. W ; Radwan, J</creatorcontrib><description>The Hamilton‐Zuk hypothesis proposes that the genetic benefits of preferences for elaborated secondary sexual traits have their origins in the arms race between hosts and parasites, which maintains genetic variance in parasite resistance. Infection, in turn, can be reflected in the expression of costly sexual ornaments. However, the link between immune genes, infection and the expression of secondary sexual traits has rarely been investigated. Here, we explored whether the presence and identity of functional variants (supertypes) of the highly polymorphic major histocompatibility complex (MHC), which is responsible for the recognition of parasites, predict the load of lung and gut parasites and antler development in the red deer (Cervus elaphus). While we found MHC supertypes to be associated with infection by a number of parasite species, including debilitating lung nematodes, we did not find support for the Hamilton‐Zuk hypothesis. On the contrary, we found that lung nematode load was positively associated with antler development. We also found that the supertypes that were associated with resistance to certain parasites at the same time cause susceptibility to others. Such trade‐offs may undermine the potential genetic benefits of mate choice for resistant partners.</description><identifier>ISSN: 1010-061X</identifier><identifier>EISSN: 1420-9101</identifier><identifier>DOI: 10.1111/jeb.12811</identifier><identifier>PMID: 26687843</identifier><language>eng</language><publisher>Switzerland: Birkhäuser</publisher><subject>Animal behavior ; Animals ; Antlers - anatomy & histology ; Antlers - growth & development ; armament ; Body Size - genetics ; Cervus elaphus ; Deer ; Deer - genetics ; Deer - parasitology ; digestive system ; Evolution & development ; genetic variance ; Genetic Variation ; Genetics ; good genes ; Host-Parasite Interactions - genetics ; hosts ; host–parasite interaction ; Lung - parasitology ; major histocompatibility complex ; Major Histocompatibility Complex - genetics ; Male ; mating behavior ; MHC polymorphism ; Nematoda ; Nematodes ; Parasites ; Poland ; red deer ; Selection, Genetic</subject><ispartof>Journal of evolutionary biology, 2016-03, Vol.29 (3), p.617-632</ispartof><rights>2015 European Society For Evolutionary Biology. Journal of Evolutionary Biology © 2015 European Society For Evolutionary Biology</rights><rights>2015 European Society For Evolutionary Biology. Journal of Evolutionary Biology © 2015 European Society For Evolutionary Biology.</rights><rights>Copyright © 2016 European Society for Evolutionary Biology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4821-fb8fd95f5437e0a8851300cb4d6d243e0d54a398757855ebf6a938eee9831c473</citedby><cites>FETCH-LOGICAL-c4821-fb8fd95f5437e0a8851300cb4d6d243e0d54a398757855ebf6a938eee9831c473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjeb.12811$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjeb.12811$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26687843$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Buczek, M</creatorcontrib><creatorcontrib>Okarma, H</creatorcontrib><creatorcontrib>Demiaszkiewicz, A. W</creatorcontrib><creatorcontrib>Radwan, J</creatorcontrib><title>MHC, parasites and antler development in red deer: no support for the Hamilton & Zuk hypothesis</title><title>Journal of evolutionary biology</title><addtitle>J Evol Biol</addtitle><description>The Hamilton‐Zuk hypothesis proposes that the genetic benefits of preferences for elaborated secondary sexual traits have their origins in the arms race between hosts and parasites, which maintains genetic variance in parasite resistance. Infection, in turn, can be reflected in the expression of costly sexual ornaments. However, the link between immune genes, infection and the expression of secondary sexual traits has rarely been investigated. Here, we explored whether the presence and identity of functional variants (supertypes) of the highly polymorphic major histocompatibility complex (MHC), which is responsible for the recognition of parasites, predict the load of lung and gut parasites and antler development in the red deer (Cervus elaphus). While we found MHC supertypes to be associated with infection by a number of parasite species, including debilitating lung nematodes, we did not find support for the Hamilton‐Zuk hypothesis. On the contrary, we found that lung nematode load was positively associated with antler development. We also found that the supertypes that were associated with resistance to certain parasites at the same time cause susceptibility to others. Such trade‐offs may undermine the potential genetic benefits of mate choice for resistant partners.</description><subject>Animal behavior</subject><subject>Animals</subject><subject>Antlers - anatomy & histology</subject><subject>Antlers - growth & development</subject><subject>armament</subject><subject>Body Size - genetics</subject><subject>Cervus elaphus</subject><subject>Deer</subject><subject>Deer - genetics</subject><subject>Deer - parasitology</subject><subject>digestive system</subject><subject>Evolution & development</subject><subject>genetic variance</subject><subject>Genetic Variation</subject><subject>Genetics</subject><subject>good genes</subject><subject>Host-Parasite Interactions - genetics</subject><subject>hosts</subject><subject>host–parasite interaction</subject><subject>Lung - parasitology</subject><subject>major histocompatibility complex</subject><subject>Major Histocompatibility Complex - genetics</subject><subject>Male</subject><subject>mating behavior</subject><subject>MHC polymorphism</subject><subject>Nematoda</subject><subject>Nematodes</subject><subject>Parasites</subject><subject>Poland</subject><subject>red deer</subject><subject>Selection, Genetic</subject><issn>1010-061X</issn><issn>1420-9101</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU9P3DAQxa2qqMufHvoFiiWkikpk8cR24vRWVpQFLeJAV6p6sZxkAtkmcWonoP32GBY4IDGSNdbTz0_jN4R8ATaFUMcrzKcQK4APZBtEzKIMGHwMdwYsYgn8mZAd71eMQSKk_EQmcZKoVAm-TfTlfHZEe-OMrwf01HRlOEODjpZ4h43tW-wGWnfUYRkkdD9oZ6kf-966gVbW0eEW6dy0dTPYjn6jf8d_9Hbd2yD72u-Rrco0Hj8_912y_HX6ezaPFldn57Ofi6gQKoaoylVVZrKSgqfIjFISOGNFLsqkjAVHVkpheKZSmSopMa8Sk3GFiJniUIiU75LDjW_v7P8R_aDb2hfYNKZDO3oNaRqDUOoJPXiDruzoujDdIwU85SyRgfq-oQpnvXdY6d7VrXFrDUw_pq5D6vop9cB-fXYc8xbLV_Il5gAcb4D7usH1-0764vTkxXJ_86IyVpsbV3u9vI7DAsMSOcThGw_5spKa</recordid><startdate>201603</startdate><enddate>201603</enddate><creator>Buczek, M</creator><creator>Okarma, H</creator><creator>Demiaszkiewicz, A. W</creator><creator>Radwan, J</creator><general>Birkhäuser</general><general>Blackwell Publishing Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7TK</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201603</creationdate><title>MHC, parasites and antler development in red deer: no support for the Hamilton & Zuk hypothesis</title><author>Buczek, M ; Okarma, H ; Demiaszkiewicz, A. W ; Radwan, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4821-fb8fd95f5437e0a8851300cb4d6d243e0d54a398757855ebf6a938eee9831c473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animal behavior</topic><topic>Animals</topic><topic>Antlers - anatomy & histology</topic><topic>Antlers - growth & development</topic><topic>armament</topic><topic>Body Size - genetics</topic><topic>Cervus elaphus</topic><topic>Deer</topic><topic>Deer - genetics</topic><topic>Deer - parasitology</topic><topic>digestive system</topic><topic>Evolution & development</topic><topic>genetic variance</topic><topic>Genetic Variation</topic><topic>Genetics</topic><topic>good genes</topic><topic>Host-Parasite Interactions - genetics</topic><topic>hosts</topic><topic>host–parasite interaction</topic><topic>Lung - parasitology</topic><topic>major histocompatibility complex</topic><topic>Major Histocompatibility Complex - genetics</topic><topic>Male</topic><topic>mating behavior</topic><topic>MHC polymorphism</topic><topic>Nematoda</topic><topic>Nematodes</topic><topic>Parasites</topic><topic>Poland</topic><topic>red deer</topic><topic>Selection, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Buczek, M</creatorcontrib><creatorcontrib>Okarma, H</creatorcontrib><creatorcontrib>Demiaszkiewicz, A. W</creatorcontrib><creatorcontrib>Radwan, J</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of evolutionary biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Buczek, M</au><au>Okarma, H</au><au>Demiaszkiewicz, A. 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Here, we explored whether the presence and identity of functional variants (supertypes) of the highly polymorphic major histocompatibility complex (MHC), which is responsible for the recognition of parasites, predict the load of lung and gut parasites and antler development in the red deer (Cervus elaphus). While we found MHC supertypes to be associated with infection by a number of parasite species, including debilitating lung nematodes, we did not find support for the Hamilton‐Zuk hypothesis. On the contrary, we found that lung nematode load was positively associated with antler development. We also found that the supertypes that were associated with resistance to certain parasites at the same time cause susceptibility to others. 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| source | MEDLINE; Access via Wiley Online Library; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals |
| subjects | Animal behavior Animals Antlers - anatomy & histology Antlers - growth & development armament Body Size - genetics Cervus elaphus Deer Deer - genetics Deer - parasitology digestive system Evolution & development genetic variance Genetic Variation Genetics good genes Host-Parasite Interactions - genetics hosts host–parasite interaction Lung - parasitology major histocompatibility complex Major Histocompatibility Complex - genetics Male mating behavior MHC polymorphism Nematoda Nematodes Parasites Poland red deer Selection, Genetic |
| title | MHC, parasites and antler development in red deer: no support for the Hamilton & Zuk hypothesis |
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