Embracing proteins: structural themes in aptamer–protein complexes

•Traditional aptamers fold into structures with established nucleic acid motifs.•Modified nucleotides expand the repertoire of known nucleic acid structural motifs.•Hydrophobic modifications make essential inter-molecular and intramolecular interactions.•The flexible phosphodiester bond of aptamers...

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Veröffentlicht in:	Current opinion in structural biology 2016-02, Vol.36, p.122-132
Hauptverfasser:	Gelinas, Amy D, Davies, Douglas R, Janjic, Nebojsa
Format:	Artikel
Sprache:	eng
Schlagworte:	Aptamers, Nucleotide - chemistry Aptamers, Nucleotide - metabolism Binding Sites Hydrophobic and Hydrophilic Interactions Ligands Models, Molecular Nucleic Acid Conformation Nucleotide Motifs Protein Binding Protein Conformation Proteins - chemistry Proteins - metabolism Structure-Activity Relationship
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