Regular blood donation may help in the management of hypertension: an observational study on 292 blood donors
BACKGROUND Hypertension is one of the leading global risks for cardiovascular events worldwide. There is preliminary evidence that regular blood donation may be beneficial. STUDY DESIGN AND METHODS Unselected blood donors were included in this observational study. Blood pressure (BP) was measured be...
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| Veröffentlicht in: | Transfusion (Philadelphia, Pa.) Pa.), 2016-03, Vol.56 (3), p.637-644 |
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| creator | Kamhieh-Milz, Sundrela Kamhieh-Milz, Julian Tauchmann, Yvonne Ostermann, Thomas Shah, Yatin Kalus, Ulrich Salama, Abdulgabar Michalsen, Andreas |
| description | BACKGROUND
Hypertension is one of the leading global risks for cardiovascular events worldwide. There is preliminary evidence that regular blood donation may be beneficial.
STUDY DESIGN AND METHODS
Unselected blood donors were included in this observational study. Blood pressure (BP) was measured before and after blood donation, with participants donating between one and four occasions in a 1‐year study period.
RESULTS
In this study, 292 donors were enrolled. At baseline, 146 had elevated BP (>140/90 mmHg). In hypertensives, after four blood donations, systolic and diastolic blood pressure (SBP and DBP, respectively) decreased from a mean of 155.9 ± 13.0 to 143.7 ± 15.0 mmHg and from 91.4 ± 9.2 to 84.5 ± 9.3 mmHg, respectively (each p |
| doi_str_mv | 10.1111/trf.13428 |
| format | Article |
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Hypertension is one of the leading global risks for cardiovascular events worldwide. There is preliminary evidence that regular blood donation may be beneficial.
STUDY DESIGN AND METHODS
Unselected blood donors were included in this observational study. Blood pressure (BP) was measured before and after blood donation, with participants donating between one and four occasions in a 1‐year study period.
RESULTS
In this study, 292 donors were enrolled. At baseline, 146 had elevated BP (>140/90 mmHg). In hypertensives, after four blood donations, systolic and diastolic blood pressure (SBP and DBP, respectively) decreased from a mean of 155.9 ± 13.0 to 143.7 ± 15.0 mmHg and from 91.4 ± 9.2 to 84.5 ± 9.3 mmHg, respectively (each p < 0.001). There was a clear dose effect with decreasing BP by the increasing number of blood donations. After at least four blood donations, donors with Stage II hypertensive baseline values (≥160 mmHg SBP and/or ≥100 mmHg DBP) were found to have the most marked reduction in BP, with 17.1 mmHg (95% confidence interval [CI], −23.2 to −11.0; p < 0.0001) and 11.7 mmHg (95% CI, −17.1 to −6.1; p = 0.0006) for SBP and DBP, respectively. The decrease in BP was not significantly associated with changes of blood count or variables of iron metabolism.
CONCLUSIONS
Regular blood donation is associated with pronounced decreases of BP in hypertensives. This beneficial effect of blood donation may open a new door regarding community health care and cost reduction in the treatment of hypertension.</description><identifier>ISSN: 0041-1132</identifier><identifier>EISSN: 1537-2995</identifier><identifier>DOI: 10.1111/trf.13428</identifier><identifier>PMID: 26643612</identifier><identifier>CODEN: TRANAT</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Blood & organ donations ; Blood donors ; Blood Donors - statistics & numerical data ; Blood pressure ; Blood Pressure - physiology ; Communities ; Confidence intervals ; Cost engineering ; Cost reduction ; Female ; Health care ; Humans ; Hypertension ; Hypertension - epidemiology ; Iron ; Male ; Management ; Metabolism ; Middle Aged ; Observational studies ; Young Adult</subject><ispartof>Transfusion (Philadelphia, Pa.), 2016-03, Vol.56 (3), p.637-644</ispartof><rights>2015 AABB</rights><rights>2015 AABB.</rights><rights>2016 AABB</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4198-5f592b1a5f31c20d4d780130746b7b95c9dcd5859b26dad1f42d94d00d11cf213</citedby><cites>FETCH-LOGICAL-c4198-5f592b1a5f31c20d4d780130746b7b95c9dcd5859b26dad1f42d94d00d11cf213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Ftrf.13428$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Ftrf.13428$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26643612$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kamhieh-Milz, Sundrela</creatorcontrib><creatorcontrib>Kamhieh-Milz, Julian</creatorcontrib><creatorcontrib>Tauchmann, Yvonne</creatorcontrib><creatorcontrib>Ostermann, Thomas</creatorcontrib><creatorcontrib>Shah, Yatin</creatorcontrib><creatorcontrib>Kalus, Ulrich</creatorcontrib><creatorcontrib>Salama, Abdulgabar</creatorcontrib><creatorcontrib>Michalsen, Andreas</creatorcontrib><title>Regular blood donation may help in the management of hypertension: an observational study on 292 blood donors</title><title>Transfusion (Philadelphia, Pa.)</title><addtitle>Transfusion</addtitle><description>BACKGROUND
Hypertension is one of the leading global risks for cardiovascular events worldwide. There is preliminary evidence that regular blood donation may be beneficial.
STUDY DESIGN AND METHODS
Unselected blood donors were included in this observational study. Blood pressure (BP) was measured before and after blood donation, with participants donating between one and four occasions in a 1‐year study period.
RESULTS
In this study, 292 donors were enrolled. At baseline, 146 had elevated BP (>140/90 mmHg). In hypertensives, after four blood donations, systolic and diastolic blood pressure (SBP and DBP, respectively) decreased from a mean of 155.9 ± 13.0 to 143.7 ± 15.0 mmHg and from 91.4 ± 9.2 to 84.5 ± 9.3 mmHg, respectively (each p < 0.001). There was a clear dose effect with decreasing BP by the increasing number of blood donations. After at least four blood donations, donors with Stage II hypertensive baseline values (≥160 mmHg SBP and/or ≥100 mmHg DBP) were found to have the most marked reduction in BP, with 17.1 mmHg (95% confidence interval [CI], −23.2 to −11.0; p < 0.0001) and 11.7 mmHg (95% CI, −17.1 to −6.1; p = 0.0006) for SBP and DBP, respectively. The decrease in BP was not significantly associated with changes of blood count or variables of iron metabolism.
CONCLUSIONS
Regular blood donation is associated with pronounced decreases of BP in hypertensives. This beneficial effect of blood donation may open a new door regarding community health care and cost reduction in the treatment of hypertension.</description><subject>Adult</subject><subject>Aged</subject><subject>Blood & organ donations</subject><subject>Blood donors</subject><subject>Blood Donors - statistics & numerical data</subject><subject>Blood pressure</subject><subject>Blood Pressure - physiology</subject><subject>Communities</subject><subject>Confidence intervals</subject><subject>Cost engineering</subject><subject>Cost reduction</subject><subject>Female</subject><subject>Health care</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - epidemiology</subject><subject>Iron</subject><subject>Male</subject><subject>Management</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Observational studies</subject><subject>Young Adult</subject><issn>0041-1132</issn><issn>1537-2995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90U1rFTEYBeAgir1WF_4BCbjRxbR58x13Wmyr1AqXiuAmZCaZ3qkzk2syo86_N_a2FQTNJgSecyAchJ4COYByDqfUHgDjVN9DKxBMVdQYcR-tCOFQATC6hx7lfEUIoYbAQ7RHpeRMAl2hYR0u594lXPcxeuzj6KYujnhwC96Efou7EU-bUN6juwxDGCccW7xZtiFNYcyFvsJuxLHOIX2_jroe52n2Cy4t1NA_xTHlx-hB6_ocntzc--jT8duLo9Pq7OPJu6PXZ1XDwehKtMLQGpxoGTSUeO6VJsCI4rJWtRGN8Y0XWpiaSu88tJx6wz0hHqBpKbB99GLXu03x2xzyZIcuN6Hv3RjinC0oRYFzrXWhz_-iV3FO5RdFGSIklcDFf5VSQKiQ2hT1cqeaFHNOobXb1A0uLRaI_b2ULUvZ66WKfXbTONdD8HfydpoCDnfgR9eH5d9N9mJ9fFtZ7RJdnsLPu4RLX61UTAn7-fzEvn8jv-jzD6d2zX4BRSuqrw</recordid><startdate>201603</startdate><enddate>201603</enddate><creator>Kamhieh-Milz, Sundrela</creator><creator>Kamhieh-Milz, Julian</creator><creator>Tauchmann, Yvonne</creator><creator>Ostermann, Thomas</creator><creator>Shah, Yatin</creator><creator>Kalus, Ulrich</creator><creator>Salama, Abdulgabar</creator><creator>Michalsen, Andreas</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201603</creationdate><title>Regular blood donation may help in the management of hypertension: an observational study on 292 blood donors</title><author>Kamhieh-Milz, Sundrela ; Kamhieh-Milz, Julian ; Tauchmann, Yvonne ; Ostermann, Thomas ; Shah, Yatin ; Kalus, Ulrich ; Salama, Abdulgabar ; Michalsen, Andreas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4198-5f592b1a5f31c20d4d780130746b7b95c9dcd5859b26dad1f42d94d00d11cf213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Blood & organ donations</topic><topic>Blood donors</topic><topic>Blood Donors - statistics & numerical data</topic><topic>Blood pressure</topic><topic>Blood Pressure - physiology</topic><topic>Communities</topic><topic>Confidence intervals</topic><topic>Cost engineering</topic><topic>Cost reduction</topic><topic>Female</topic><topic>Health care</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension - epidemiology</topic><topic>Iron</topic><topic>Male</topic><topic>Management</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Observational studies</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kamhieh-Milz, Sundrela</creatorcontrib><creatorcontrib>Kamhieh-Milz, Julian</creatorcontrib><creatorcontrib>Tauchmann, Yvonne</creatorcontrib><creatorcontrib>Ostermann, Thomas</creatorcontrib><creatorcontrib>Shah, Yatin</creatorcontrib><creatorcontrib>Kalus, Ulrich</creatorcontrib><creatorcontrib>Salama, Abdulgabar</creatorcontrib><creatorcontrib>Michalsen, Andreas</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transfusion (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kamhieh-Milz, Sundrela</au><au>Kamhieh-Milz, Julian</au><au>Tauchmann, Yvonne</au><au>Ostermann, Thomas</au><au>Shah, Yatin</au><au>Kalus, Ulrich</au><au>Salama, Abdulgabar</au><au>Michalsen, Andreas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regular blood donation may help in the management of hypertension: an observational study on 292 blood donors</atitle><jtitle>Transfusion (Philadelphia, Pa.)</jtitle><addtitle>Transfusion</addtitle><date>2016-03</date><risdate>2016</risdate><volume>56</volume><issue>3</issue><spage>637</spage><epage>644</epage><pages>637-644</pages><issn>0041-1132</issn><eissn>1537-2995</eissn><coden>TRANAT</coden><abstract>BACKGROUND
Hypertension is one of the leading global risks for cardiovascular events worldwide. There is preliminary evidence that regular blood donation may be beneficial.
STUDY DESIGN AND METHODS
Unselected blood donors were included in this observational study. Blood pressure (BP) was measured before and after blood donation, with participants donating between one and four occasions in a 1‐year study period.
RESULTS
In this study, 292 donors were enrolled. At baseline, 146 had elevated BP (>140/90 mmHg). In hypertensives, after four blood donations, systolic and diastolic blood pressure (SBP and DBP, respectively) decreased from a mean of 155.9 ± 13.0 to 143.7 ± 15.0 mmHg and from 91.4 ± 9.2 to 84.5 ± 9.3 mmHg, respectively (each p < 0.001). There was a clear dose effect with decreasing BP by the increasing number of blood donations. After at least four blood donations, donors with Stage II hypertensive baseline values (≥160 mmHg SBP and/or ≥100 mmHg DBP) were found to have the most marked reduction in BP, with 17.1 mmHg (95% confidence interval [CI], −23.2 to −11.0; p < 0.0001) and 11.7 mmHg (95% CI, −17.1 to −6.1; p = 0.0006) for SBP and DBP, respectively. The decrease in BP was not significantly associated with changes of blood count or variables of iron metabolism.
CONCLUSIONS
Regular blood donation is associated with pronounced decreases of BP in hypertensives. This beneficial effect of blood donation may open a new door regarding community health care and cost reduction in the treatment of hypertension.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>26643612</pmid><doi>10.1111/trf.13428</doi><tpages>8</tpages></addata></record> |
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| ispartof | Transfusion (Philadelphia, Pa.), 2016-03, Vol.56 (3), p.637-644 |
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| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Adult Aged Blood & organ donations Blood donors Blood Donors - statistics & numerical data Blood pressure Blood Pressure - physiology Communities Confidence intervals Cost engineering Cost reduction Female Health care Humans Hypertension Hypertension - epidemiology Iron Male Management Metabolism Middle Aged Observational studies Young Adult |
| title | Regular blood donation may help in the management of hypertension: an observational study on 292 blood donors |
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