A Novel Adjuvant for Mucosal Immunity to HIV-1 gp120 in Nonhuman Primates

The development of a safe and effective mucosal adjuvant is a crucial step toward a mucosal HIV/AIDS vaccine. This study seeks to determine the promise of a nontoxic mutant of cholera toxin (mCT; E112K) as a mucosal adjuvant in nonhuman primates. HIV-1 gp120 was nasally administered together with mC...

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Veröffentlicht in:	The Journal of immunology (1950) 2004-12, Vol.173 (11), p.6850-6857
Hauptverfasser:	Yoshino, Naoto, Lu, Fabien X.-S, Fujihashi, Kohtaro, Hagiwara, Yukari, Kataoka, Kosuke, Lu, Ding, Hirst, Linda, Honda, Mitsuo, van Ginkel, Frederik W, Takeda, Yoshifumi, Miller, Christopher J, Kiyono, Hiroshi, McGhee, Jerry R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Adjuvants, Immunologic - adverse effects AIDS Vaccines - administration & dosage AIDS Vaccines - immunology Animals Antibody-Producing Cells - immunology Antibody-Producing Cells - metabolism Cholera Toxin - administration & dosage Cholera Toxin - adverse effects Cholera Toxin - immunology Epitopes, T-Lymphocyte - immunology Female HIV Antibodies - biosynthesis HIV Antibodies - blood HIV Envelope Protein gp120 - administration & dosage HIV Envelope Protein gp120 - immunology HIV-1 - immunology Human immunodeficiency virus 1 Immunity, Mucosal Immunoglobulin A - biosynthesis Immunoglobulin G - biosynthesis Lymphoid Tissue - immunology Lymphoid Tissue - metabolism Macaca mulatta Male Nasal Mucosa - immunology Nasal Mucosa - metabolism Neutralization Tests Primates Th1 Cells - immunology Th1 Cells - metabolism Th2 Cells - immunology Th2 Cells - metabolism
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