Rapamycin, a specific inhibitor of the target of rapamycin complex 1, disrupts intestinal barrier integrity in broiler chicks

To uncover the molecular mechanisms underlying the intestinal barrier integrity, this study determined whether the rapamycin (RAPA)‐sensitive target of rapamycin complex 1 (TORC1) pathway was involved in this process. Three groups of 4‐day‐old male chicks were randomly subjected to one of the follow...

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Veröffentlicht in:	Journal of animal physiology and animal nutrition 2016-04, Vol.100 (2), p.323-330
Hauptverfasser:	Liu, S. Q, Zhao, J. P, Fan, X. X, Liu, G. H, Jiao, H. C, Wang, X. J, Sun, S. H, Lin, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals body weight broiler chickens broiler chicks Chickens chicks dose response Immunoglobulin A intestinal barrier integrity intestinal mucosa Intestinal Mucosa - drug effects intraperitoneal injection jejunum Male males Mechanistic Target of Rapamycin Complex 1 mortality Multiprotein Complexes - antagonists & inhibitors phosphorylation Poultry Diseases - pathology rapamycin Sirolimus - pharmacology target of rapamycin complex 1 TOR Serine-Threonine Kinases - antagonists & inhibitors villi weight loss
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