Chemokines induce eosinophil degranulation through CCR-3

Background: Such CC chemokines as eotaxin and RANTES induce preferential eosinophil recruitment in allergic inflammation. They also elicit proinflammatory effector functions of eosinophils, such as enhanced adhesion and superoxide generation. Eosinophil degranulation by chemokines, however, has not...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2000-09, Vol.106 (3), p.507-513
Hauptverfasser:	Fujisawa, Takao, Kato, Yoshiko, Nagase, Hiroyuki, Atsuta, Jun, Terada, Akihiko, Iguchi, Kosei, Kamiya, Hitoshi, Morita, Yutaka, Kitaura, Motoji, Kawasaki, Hiroshi, Yoshie, Osamu, Hirai, Koichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergic diseases Biological and medical sciences Calcium - blood CC chemokines CCR3 CCR3 protein Cell Degranulation - drug effects Chemokines - pharmacology degranulation Eosinophils Eosinophils - cytology eotaxin General aspects Humans Immunopathology Medical sciences RANTES Receptors, CCR3 Receptors, Chemokine - physiology Time Factors
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