Mice with Markedly Reduced PACAP (PAC1) Receptor Expression by Targeted Deletion of the Signal Peptide

: In an attempt to study the pituitary adenylate cyclase‐activating polypeptide (PACAP) type 1 (PAC1) receptor (PAC1R) function in vivo and to produce a mouse model with altered expression of PAC1R, we have used gene targeting in embryonic stem cells to disrupt exon 2 of the PAC1R gene, which contai...

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Veröffentlicht in:	Journal of neurochemistry 2000-11, Vol.75 (5), p.1810-1817
Hauptverfasser:	Hashimoto, Hitoshi, Shintani, Norihito, Nishino, Akiko, Okabe, Masaru, Ikawa, Masahito, Matsuyama, Shogo, Itoh, Kyoko, Yamamoto, Kyohei, Tomimoto, Shuhei, Fujita, Takashi, Hagihara, Nami, Mori, Wakaba, Koyama, Yutaka, Matsuda, Toshio, Nagata, Shigekazu, Baba, Akemichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding, Competitive - genetics Biological and medical sciences Brain - metabolism Cell Membrane - metabolism Cell receptors Cell structures and functions Cell surface expression COS Cells Exons - genetics Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology Gene Targeting Glycosylation Homozygote Mice Mice, Mutant Strains Molecular and cellular biology Mutagenesis, Site-Directed Neuropeptide receptors Neuropeptides - metabolism Phenotype Pituitary Adenylate Cyclase-Activating Polypeptide Pituitary adenylate cyclase‐activating polypeptide receptor Protein Sorting Signals - genetics Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I Receptors, Pituitary Hormone - genetics Receptors, Pituitary Hormone - metabolism RNA, Messenger - biosynthesis Sequence Deletion Signal peptide Structure-Activity Relationship Transfection
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