Receptor for Activated C-Kinase (RACK-1), a WD Motif-Containing Protein, Specifically Associates with the Human Type I IFN Receptor

The cytoplasmic domain of the human type I IFN receptor chain 2 (IFNAR2c or IFN-alphaRbetaL) was used as bait in a yeast two-hybrid system to identify novel proteins interacting with this region of the receptor. We report here a specific interaction between the cytoplasmic domain of IFN-alphaRbetaL...

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Veröffentlicht in:	The Journal of immunology (1950) 2000-11, Vol.165 (9), p.5127-5132
Hauptverfasser:	Croze, Ed, Usacheva, Anna, Asarnow, David, Minshall, Richard D, Perez, H. D, Colamonici, Oscar
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs - genetics Amino Acid Motifs - immunology Aspartic Acid Cell Line Enzyme Activation - genetics Enzyme Activation - immunology Humans interferon receptors Interferon Type I - metabolism Interferon Type I - pharmacology Intracellular Fluid - drug effects Intracellular Fluid - immunology Intracellular Fluid - metabolism Membrane Proteins Peptide Mapping Precipitin Tests Protein Binding - genetics Protein Binding - immunology Protein Kinase C - genetics Protein Kinase C - metabolism RACK1 protein Receptor, Interferon alpha-beta Receptors for Activated C Kinase Receptors, Cell Surface - genetics Receptors, Cell Surface - isolation & purification Receptors, Cell Surface - metabolism Receptors, Interferon - genetics Receptors, Interferon - isolation & purification Receptors, Interferon - metabolism Repetitive Sequences, Amino Acid - genetics Repetitive Sequences, Amino Acid - immunology Saccharomyces cerevisiae - genetics Tetradecanoylphorbol Acetate - pharmacology Tryptophan Tumor Cells, Cultured Two-Hybrid System Techniques
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