A New Class of Safe Oligosaccharide Polymer Therapy To Modify the Mucus Barrier of Chronic Respiratory Disease

The host- and bacteria-derived extracellular polysaccharide coating of the lung is a considerable challenge in chronic respiratory disease and is a powerful barrier to effective drug delivery. A low molecular weight 12–15-mer alginate oligosaccharide (OligoG CF-5/20), derived from plant biopolymers,...

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Veröffentlicht in:	Molecular pharmaceutics 2016-03, Vol.13 (3), p.863-872
Hauptverfasser:	Pritchard, Manon F, Powell, Lydia C, Menzies, Georgina E, Lewis, Paul D, Hawkins, Karl, Wright, Chris, Doull, Iolo, Walsh, Timothy R, Onsøyen, Edvar, Dessen, Arne, Myrvold, Rolf, Rye, Philip D, Myrset, Astrid H, Stevens, Howard N. E, Hodges, Lee A, MacGregor, Gordon, Neilly, James B, Hill, Katja E, Thomas, David W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Alginates - chemistry Alginates - metabolism Animals Chronic Disease Clinical Trials, Phase I as Topic Cystic Fibrosis - drug therapy Female Glucuronic Acid - chemistry Glucuronic Acid - metabolism Hexuronic Acids - chemistry Hexuronic Acids - metabolism Humans Male Microscopy, Atomic Force Microscopy, Electron, Scanning Mucins - chemistry Mucins - metabolism Mucus - chemistry Mucus - metabolism Oligosaccharides - chemistry Oligosaccharides - metabolism Polymers - chemistry Polymers - pharmacology Rats Rats, Sprague-Dawley Rheology Spectroscopy, Fourier Transform Infrared Sputum - chemistry Swine Young Adult
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