Anticancer activity of Ashwagandha against human head and neck cancer cell lines

Background The aim of this study was to determine the apoptotic activity of methanol extract of Ashwagandha (MEAG) and in human head and neck squamous cell carcinoma (HNSCC) cells and to investigate the underlying mechanisms. Methods We investigated the effects of MEAG on programmed cell death in HN...

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Veröffentlicht in:	Journal of oral pathology & medicine 2016-03, Vol.45 (3), p.193-201
Hauptverfasser:	Lee, Haeng-Eun, Shin, Ji-Ae, Jeong, Joseph H., Jeon, Jae-Gyu, Lee, Min-Ho, Cho, Sung-Dae
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology apoptosis Apoptosis - drug effects Apoptosis Regulatory Proteins - metabolism Ashwagandha Bcl-2-Like Protein 11 - deficiency Bcl-2-Like Protein 11 - genetics Bcl-2-Like Protein 11 - metabolism Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Caspase 8 - metabolism Caspase 9 - drug effects Caspase 9 - metabolism Cell Line, Tumor Cytochromes c - metabolism Dentistry Enzyme Activation - drug effects head and neck cancer Head and Neck Neoplasms - drug therapy Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - pathology Humans Membrane Potential, Mitochondrial - drug effects Mitochondrial Membranes - drug effects Mouth Neoplasms - drug therapy Plant Extracts - pharmacology Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism Squamous Cell Carcinoma of Head and Neck Up-Regulation Withanolides - pharmacology
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