Darier disease
Darier disease (DD) is a type of inherited keratinizing disorder that exhibits autosomal dominant inheritance. DD is caused by the mutations of ATP2A2, which encodes an endoplasmic reticulum calcium pump, sarco/endoplasmic reticulum ATPase type 2 (SERCA2). DD often develops in childhood, persists th...
Gespeichert in:
| Veröffentlicht in: | Journal of dermatology 2016-03, Vol.43 (3), p.275-279 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 279 |
|---|---|
| container_issue | 3 |
| container_start_page | 275 |
| container_title | Journal of dermatology |
| container_volume | 43 |
| creator | Takagi, Atsushi Kamijo, Maya Ikeda, Shigaku |
| description | Darier disease (DD) is a type of inherited keratinizing disorder that exhibits autosomal dominant inheritance. DD is caused by the mutations of ATP2A2, which encodes an endoplasmic reticulum calcium pump, sarco/endoplasmic reticulum ATPase type 2 (SERCA2). DD often develops in childhood, persists through adolescence, and causes small papules predominantly in seborrheic areas such as the face, chest and back. Further, scales and scabs may gradually develop. DD may be accompanied by non‐dermal symptoms, including psychiatric symptoms. Histologically, DD is characterized by corps ronds and grains in addition to suprabasal cleavage. There are no currently validated curative treatments available for DD, with the majority of cases treated symptomatically. Despite demonstrating efficacy in the treatment of DD, the use of oral retinoids has been limited due to the association with various adverse effects. |
| doi_str_mv | 10.1111/1346-8138.13230 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1771448054</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3038343745</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5270-797142807a34dbd51851ea8e650c2f3e92817e31f12a0afab3d0ca552a4cd7713</originalsourceid><addsrcrecordid>eNqFkE1PAjEQhhujEUS9ejMmXrwstJ3OthwNIH4Q5KDBeGnKbjdZXD5s2Sj_3uIiBw_ayyTN8z6ZeQk5Y7TJwmsxEHGkGKgmAw50j9R3P_ukTkFhxAWVNXLk_ZRS3kZGD0mNx22BCFgnp13jcusu0txb4-0xOchM4e3JdjbI803vqXMbDR77d53rQZQglzSSbckEV1QaEOkkRaaQWaNsjDThGdg2V0xaYBnjhprMTCCliUHkRiSplAwa5KryLt3ivbR-pWe5T2xRmLldlF6zAAmhKIqAXv5Cp4vSzcN2GsKBIEAK_IsKLooKOIdAtSoqcQvvnc300uUz49aaUb0pVG_q05v69HehIXG-9ZaTmU13_E-DAcAK-MgLu_7Pp--7vR9xVOVyv7Kfu5xxbzqWIFGPh309Go_4w-vwRSN8AaqpiU8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1770583223</pqid></control><display><type>article</type><title>Darier disease</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Takagi, Atsushi ; Kamijo, Maya ; Ikeda, Shigaku</creator><creatorcontrib>Takagi, Atsushi ; Kamijo, Maya ; Ikeda, Shigaku</creatorcontrib><description>Darier disease (DD) is a type of inherited keratinizing disorder that exhibits autosomal dominant inheritance. DD is caused by the mutations of ATP2A2, which encodes an endoplasmic reticulum calcium pump, sarco/endoplasmic reticulum ATPase type 2 (SERCA2). DD often develops in childhood, persists through adolescence, and causes small papules predominantly in seborrheic areas such as the face, chest and back. Further, scales and scabs may gradually develop. DD may be accompanied by non‐dermal symptoms, including psychiatric symptoms. Histologically, DD is characterized by corps ronds and grains in addition to suprabasal cleavage. There are no currently validated curative treatments available for DD, with the majority of cases treated symptomatically. Despite demonstrating efficacy in the treatment of DD, the use of oral retinoids has been limited due to the association with various adverse effects.</description><identifier>ISSN: 0385-2407</identifier><identifier>EISSN: 1346-8138</identifier><identifier>DOI: 10.1111/1346-8138.13230</identifier><identifier>PMID: 26945535</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>ATP2A2 ; Autosomal dominant inheritance ; Ca2+-transporting ATPase ; Calcium (reticular) ; Children ; Darier disease ; Darier Disease - diagnosis ; Darier Disease - genetics ; Darier Disease - therapy ; Darier's disease ; Diagnosis, Differential ; Endoplasmic reticulum ; Hereditary diseases ; Humans ; Keratosis ; Mutation ; pathogenesis ; Retinoids ; review ; sarco/endoplasmic reticulum ATPase type 2 ; Sarcoplasmic Reticulum Calcium-Transporting ATPases - genetics</subject><ispartof>Journal of dermatology, 2016-03, Vol.43 (3), p.275-279</ispartof><rights>2016 Japanese Dermatological Association</rights><rights>2016 Japanese Dermatological Association.</rights><rights>Copyright © 2016 Japanese Dermatological Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5270-797142807a34dbd51851ea8e650c2f3e92817e31f12a0afab3d0ca552a4cd7713</citedby><cites>FETCH-LOGICAL-c5270-797142807a34dbd51851ea8e650c2f3e92817e31f12a0afab3d0ca552a4cd7713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1346-8138.13230$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1346-8138.13230$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26945535$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takagi, Atsushi</creatorcontrib><creatorcontrib>Kamijo, Maya</creatorcontrib><creatorcontrib>Ikeda, Shigaku</creatorcontrib><title>Darier disease</title><title>Journal of dermatology</title><addtitle>J Dermatol</addtitle><description>Darier disease (DD) is a type of inherited keratinizing disorder that exhibits autosomal dominant inheritance. DD is caused by the mutations of ATP2A2, which encodes an endoplasmic reticulum calcium pump, sarco/endoplasmic reticulum ATPase type 2 (SERCA2). DD often develops in childhood, persists through adolescence, and causes small papules predominantly in seborrheic areas such as the face, chest and back. Further, scales and scabs may gradually develop. DD may be accompanied by non‐dermal symptoms, including psychiatric symptoms. Histologically, DD is characterized by corps ronds and grains in addition to suprabasal cleavage. There are no currently validated curative treatments available for DD, with the majority of cases treated symptomatically. Despite demonstrating efficacy in the treatment of DD, the use of oral retinoids has been limited due to the association with various adverse effects.</description><subject>ATP2A2</subject><subject>Autosomal dominant inheritance</subject><subject>Ca2+-transporting ATPase</subject><subject>Calcium (reticular)</subject><subject>Children</subject><subject>Darier disease</subject><subject>Darier Disease - diagnosis</subject><subject>Darier Disease - genetics</subject><subject>Darier Disease - therapy</subject><subject>Darier's disease</subject><subject>Diagnosis, Differential</subject><subject>Endoplasmic reticulum</subject><subject>Hereditary diseases</subject><subject>Humans</subject><subject>Keratosis</subject><subject>Mutation</subject><subject>pathogenesis</subject><subject>Retinoids</subject><subject>review</subject><subject>sarco/endoplasmic reticulum ATPase type 2</subject><subject>Sarcoplasmic Reticulum Calcium-Transporting ATPases - genetics</subject><issn>0385-2407</issn><issn>1346-8138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1PAjEQhhujEUS9ejMmXrwstJ3OthwNIH4Q5KDBeGnKbjdZXD5s2Sj_3uIiBw_ayyTN8z6ZeQk5Y7TJwmsxEHGkGKgmAw50j9R3P_ukTkFhxAWVNXLk_ZRS3kZGD0mNx22BCFgnp13jcusu0txb4-0xOchM4e3JdjbI803vqXMbDR77d53rQZQglzSSbckEV1QaEOkkRaaQWaNsjDThGdg2V0xaYBnjhprMTCCliUHkRiSplAwa5KryLt3ivbR-pWe5T2xRmLldlF6zAAmhKIqAXv5Cp4vSzcN2GsKBIEAK_IsKLooKOIdAtSoqcQvvnc300uUz49aaUb0pVG_q05v69HehIXG-9ZaTmU13_E-DAcAK-MgLu_7Pp--7vR9xVOVyv7Kfu5xxbzqWIFGPh309Go_4w-vwRSN8AaqpiU8</recordid><startdate>201603</startdate><enddate>201603</enddate><creator>Takagi, Atsushi</creator><creator>Kamijo, Maya</creator><creator>Ikeda, Shigaku</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201603</creationdate><title>Darier disease</title><author>Takagi, Atsushi ; Kamijo, Maya ; Ikeda, Shigaku</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5270-797142807a34dbd51851ea8e650c2f3e92817e31f12a0afab3d0ca552a4cd7713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>ATP2A2</topic><topic>Autosomal dominant inheritance</topic><topic>Ca2+-transporting ATPase</topic><topic>Calcium (reticular)</topic><topic>Children</topic><topic>Darier disease</topic><topic>Darier Disease - diagnosis</topic><topic>Darier Disease - genetics</topic><topic>Darier Disease - therapy</topic><topic>Darier's disease</topic><topic>Diagnosis, Differential</topic><topic>Endoplasmic reticulum</topic><topic>Hereditary diseases</topic><topic>Humans</topic><topic>Keratosis</topic><topic>Mutation</topic><topic>pathogenesis</topic><topic>Retinoids</topic><topic>review</topic><topic>sarco/endoplasmic reticulum ATPase type 2</topic><topic>Sarcoplasmic Reticulum Calcium-Transporting ATPases - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takagi, Atsushi</creatorcontrib><creatorcontrib>Kamijo, Maya</creatorcontrib><creatorcontrib>Ikeda, Shigaku</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takagi, Atsushi</au><au>Kamijo, Maya</au><au>Ikeda, Shigaku</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Darier disease</atitle><jtitle>Journal of dermatology</jtitle><addtitle>J Dermatol</addtitle><date>2016-03</date><risdate>2016</risdate><volume>43</volume><issue>3</issue><spage>275</spage><epage>279</epage><pages>275-279</pages><issn>0385-2407</issn><eissn>1346-8138</eissn><abstract>Darier disease (DD) is a type of inherited keratinizing disorder that exhibits autosomal dominant inheritance. DD is caused by the mutations of ATP2A2, which encodes an endoplasmic reticulum calcium pump, sarco/endoplasmic reticulum ATPase type 2 (SERCA2). DD often develops in childhood, persists through adolescence, and causes small papules predominantly in seborrheic areas such as the face, chest and back. Further, scales and scabs may gradually develop. DD may be accompanied by non‐dermal symptoms, including psychiatric symptoms. Histologically, DD is characterized by corps ronds and grains in addition to suprabasal cleavage. There are no currently validated curative treatments available for DD, with the majority of cases treated symptomatically. Despite demonstrating efficacy in the treatment of DD, the use of oral retinoids has been limited due to the association with various adverse effects.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>26945535</pmid><doi>10.1111/1346-8138.13230</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0385-2407 |
| ispartof | Journal of dermatology, 2016-03, Vol.43 (3), p.275-279 |
| issn | 0385-2407 1346-8138 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1771448054 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | ATP2A2 Autosomal dominant inheritance Ca2+-transporting ATPase Calcium (reticular) Children Darier disease Darier Disease - diagnosis Darier Disease - genetics Darier Disease - therapy Darier's disease Diagnosis, Differential Endoplasmic reticulum Hereditary diseases Humans Keratosis Mutation pathogenesis Retinoids review sarco/endoplasmic reticulum ATPase type 2 Sarcoplasmic Reticulum Calcium-Transporting ATPases - genetics |
| title | Darier disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-19T08%3A20%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Darier%20disease&rft.jtitle=Journal%20of%20dermatology&rft.au=Takagi,%20Atsushi&rft.date=2016-03&rft.volume=43&rft.issue=3&rft.spage=275&rft.epage=279&rft.pages=275-279&rft.issn=0385-2407&rft.eissn=1346-8138&rft_id=info:doi/10.1111/1346-8138.13230&rft_dat=%3Cproquest_cross%3E3038343745%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1770583223&rft_id=info:pmid/26945535&rfr_iscdi=true |