PDGF-BB Enhances the Proliferation of Cells in Human Orbital Fibroblasts by Suppressing PDCD4 Expression Via Up-Regulation of microRNA-21

The aim of this study was to investigate the effect of platelet-derived growth factor (PDGF)-BB on the proliferation of cells and its possible mechanism in human orbital fibroblasts. Human orbital fibroblasts were obtained from orbital fat from decompression surgery in patients with thyroid-associat...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2016-03, Vol.57 (3), p.908-913
Hauptverfasser:	Lee, Ji-Young, Yun, Mihee, Paik, Ji-Sun, Lee, Seong-Beom, Yang, Suk-Woo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Apoptosis Regulatory Proteins - biosynthesis Apoptosis Regulatory Proteins - genetics Blotting, Western Cell Proliferation - drug effects Cell Proliferation - genetics Cells, Cultured Female Fibroblasts - drug effects Fibroblasts - metabolism Fibroblasts - pathology Gene Expression Regulation Graves Ophthalmopathy - genetics Graves Ophthalmopathy - pathology Graves Ophthalmopathy - therapy Humans Male MicroRNAs - biosynthesis MicroRNAs - genetics Middle Aged Orbit - pathology Proto-Oncogene Proteins c-sis - pharmacology Real-Time Polymerase Chain Reaction Recombinant Proteins RNA - genetics RNA-Binding Proteins - biosynthesis RNA-Binding Proteins - genetics Up-Regulation Young Adult
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