Toxicokinetic-Toxicodynamic Relationships in Two Cases of Flecainide Poisonings

Toxicokinetic-Toxicodynamic Relationships in Two Cases of Flecainide Poisonings

Flecainide is a cardiotropic drug with a membrane stabilising effect, responsible for rare but severe acute poisonings. Prognostic factors have been proposed but never validated, including the supposed ingested dose and QRS width. To date, no toxicokinetic data has been published and the predictive...

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Veröffentlicht in:Journal of toxicology. Clinical toxicology 2004-06, Vol.42 (4), p.477-477
Hauptverfasser: Megarbane, B, Delhotal, B, Tchir, M, Resiere, D, Baud, F
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container_title Journal of toxicology. Clinical toxicology
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creator Megarbane, B
Delhotal, B
Tchir, M
Resiere, D
Baud, F
description Flecainide is a cardiotropic drug with a membrane stabilising effect, responsible for rare but severe acute poisonings. Prognostic factors have been proposed but never validated, including the supposed ingested dose and QRS width. To date, no toxicokinetic data has been published and the predictive value of plasma concentration on outcome is unknown.
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source Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete
title Toxicokinetic-Toxicodynamic Relationships in Two Cases of Flecainide Poisonings
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