Toxicokinetic-Toxicodynamic Relationships in Two Cases of Flecainide Poisonings

Flecainide is a cardiotropic drug with a membrane stabilising effect, responsible for rare but severe acute poisonings. Prognostic factors have been proposed but never validated, including the supposed ingested dose and QRS width. To date, no toxicokinetic data has been published and the predictive value of plasma concentration on outcome is unknown.