Locomotor and learning deficits in adult rats exposed to monosodium- l-glutamate during early life
Neonatal administration of neurotoxic doses of monosodium- l-glutamate (MSG) to rats causes neuronal necrosis of the hypothalamus along with behavioral abnormalities. In the present study the behavioral effects in rats treated with subneurotoxic doses of MSG (2 mg/g, p.o., for 10 days) at the weaned...
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| Veröffentlicht in: | Neuroscience letters 2000-04, Vol.284 (1), p.57-60 |
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| creator | Ali, M.Mohd Bawari, M Misra, U.K Babu, G.N |
| description | Neonatal administration of neurotoxic doses of monosodium-
l-glutamate (MSG) to rats causes neuronal necrosis of the hypothalamus along with behavioral abnormalities. In the present study the behavioral effects in rats treated with subneurotoxic doses of MSG (2 mg/g, p.o., for 10 days) at the weaned stage were investigated at day 90 post-dosing. The MSG-treated rats did not show significant changes in any of the components of spontaneous locomotor activity but, after apomorphine challenge, marked decreases in the distance travelled, ambulatory and stereotypic times, and the number of stereotypic movements with an increase in the resting time were observed. Significant decrease in the active avoidance learning performance was observed in the MSG-treated rats in the learning (acquisition) phase without any changes in the extinction and relearning phases. The results indicate that exposure to MSG in early life in rats could lead to subtle behavioral aberrations in late adulthood. |
| doi_str_mv | 10.1016/S0304-3940(00)00958-7 |
| format | Article |
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l-glutamate (MSG) to rats causes neuronal necrosis of the hypothalamus along with behavioral abnormalities. In the present study the behavioral effects in rats treated with subneurotoxic doses of MSG (2 mg/g, p.o., for 10 days) at the weaned stage were investigated at day 90 post-dosing. The MSG-treated rats did not show significant changes in any of the components of spontaneous locomotor activity but, after apomorphine challenge, marked decreases in the distance travelled, ambulatory and stereotypic times, and the number of stereotypic movements with an increase in the resting time were observed. Significant decrease in the active avoidance learning performance was observed in the MSG-treated rats in the learning (acquisition) phase without any changes in the extinction and relearning phases. The results indicate that exposure to MSG in early life in rats could lead to subtle behavioral aberrations in late adulthood.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/S0304-3940(00)00958-7</identifier><identifier>PMID: 10771161</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Age Factors ; Animals ; Apomorphine - pharmacology ; Biological and medical sciences ; Brain - drug effects ; Brain - physiology ; Dopamine Agonists - pharmacology ; Food toxicology ; Learning ; Learning Disorders - etiology ; Locomotor Activity ; Male ; Medical sciences ; Monosodium- l-glutamate ; Movement Disorders - etiology ; Neurons - drug effects ; Neurons - metabolism ; Rat ; Rats ; Rats, Inbred Strains ; Receptors, N-Methyl-D-Aspartate - drug effects ; Receptors, N-Methyl-D-Aspartate - metabolism ; Sodium Glutamate - adverse effects ; Subneuroxic dose ; Toxicology ; Weaning</subject><ispartof>Neuroscience letters, 2000-04, Vol.284 (1), p.57-60</ispartof><rights>2000 Elsevier Science Ireland Ltd</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-2b348512c33771015fbc50abdd905f4c33103a5ac2c143df8788408d5ab7ce73</citedby><cites>FETCH-LOGICAL-c421t-2b348512c33771015fbc50abdd905f4c33103a5ac2c143df8788408d5ab7ce73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304394000009587$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1363250$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10771161$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ali, M.Mohd</creatorcontrib><creatorcontrib>Bawari, M</creatorcontrib><creatorcontrib>Misra, U.K</creatorcontrib><creatorcontrib>Babu, G.N</creatorcontrib><title>Locomotor and learning deficits in adult rats exposed to monosodium- l-glutamate during early life</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>Neonatal administration of neurotoxic doses of monosodium-
l-glutamate (MSG) to rats causes neuronal necrosis of the hypothalamus along with behavioral abnormalities. In the present study the behavioral effects in rats treated with subneurotoxic doses of MSG (2 mg/g, p.o., for 10 days) at the weaned stage were investigated at day 90 post-dosing. The MSG-treated rats did not show significant changes in any of the components of spontaneous locomotor activity but, after apomorphine challenge, marked decreases in the distance travelled, ambulatory and stereotypic times, and the number of stereotypic movements with an increase in the resting time were observed. Significant decrease in the active avoidance learning performance was observed in the MSG-treated rats in the learning (acquisition) phase without any changes in the extinction and relearning phases. The results indicate that exposure to MSG in early life in rats could lead to subtle behavioral aberrations in late adulthood.</description><subject>Age Factors</subject><subject>Animals</subject><subject>Apomorphine - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Brain - drug effects</subject><subject>Brain - physiology</subject><subject>Dopamine Agonists - pharmacology</subject><subject>Food toxicology</subject><subject>Learning</subject><subject>Learning Disorders - etiology</subject><subject>Locomotor Activity</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Monosodium- l-glutamate</subject><subject>Movement Disorders - etiology</subject><subject>Neurons - drug effects</subject><subject>Neurons - metabolism</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Receptors, N-Methyl-D-Aspartate - drug effects</subject><subject>Receptors, N-Methyl-D-Aspartate - metabolism</subject><subject>Sodium Glutamate - adverse effects</subject><subject>Subneuroxic dose</subject><subject>Toxicology</subject><subject>Weaning</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFq3DAQhkVpSbZpHqFFhxLag5ORJa28p1JCkhYWckjuQpbGQUW2NpJckrev3F3a3AKCQcM3_wwfIR8ZnDNg64s74CAavhHwBeArwEZ2jXpDVqxTbaM2qn1LVv-QY_I-518AIJkUR-SYgVKMrdmK9Nto4xhLTNRMjgY0afLTA3U4eOtLpn6ixs2h0GTqD592MaOjJdIxTjFH5-exoaF5CHMxoylI3ZyWgBoUnmnwA34g7wYTMp4e6gm5v766v_zRbG9vfl5-3zZWtKw0bc9FJ1lrOa_HAZNDbyWY3rkNyEHUNgNupLGtZYK7oVNdJ6Bz0vTKouIn5Gwfu0vxccZc9OizxRDMhHHOmtXUdi1EBeUetCnmnHDQu-RHk541A7241X_d6kWchuVVt3pZ8OmwYO5HdC-m9jIr8PkAmGxNGJKZrM__Ob7mrYSKfdtjWGX89ph0th4ni84ntEW76F-55A8EipXg</recordid><startdate>20000421</startdate><enddate>20000421</enddate><creator>Ali, M.Mohd</creator><creator>Bawari, M</creator><creator>Misra, U.K</creator><creator>Babu, G.N</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20000421</creationdate><title>Locomotor and learning deficits in adult rats exposed to monosodium- l-glutamate during early life</title><author>Ali, M.Mohd ; Bawari, M ; Misra, U.K ; Babu, G.N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-2b348512c33771015fbc50abdd905f4c33103a5ac2c143df8788408d5ab7ce73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Age Factors</topic><topic>Animals</topic><topic>Apomorphine - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Brain - drug effects</topic><topic>Brain - physiology</topic><topic>Dopamine Agonists - pharmacology</topic><topic>Food toxicology</topic><topic>Learning</topic><topic>Learning Disorders - etiology</topic><topic>Locomotor Activity</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Monosodium- l-glutamate</topic><topic>Movement Disorders - etiology</topic><topic>Neurons - drug effects</topic><topic>Neurons - metabolism</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Receptors, N-Methyl-D-Aspartate - drug effects</topic><topic>Receptors, N-Methyl-D-Aspartate - metabolism</topic><topic>Sodium Glutamate - adverse effects</topic><topic>Subneuroxic dose</topic><topic>Toxicology</topic><topic>Weaning</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ali, M.Mohd</creatorcontrib><creatorcontrib>Bawari, M</creatorcontrib><creatorcontrib>Misra, U.K</creatorcontrib><creatorcontrib>Babu, G.N</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ali, M.Mohd</au><au>Bawari, M</au><au>Misra, U.K</au><au>Babu, G.N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Locomotor and learning deficits in adult rats exposed to monosodium- l-glutamate during early life</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2000-04-21</date><risdate>2000</risdate><volume>284</volume><issue>1</issue><spage>57</spage><epage>60</epage><pages>57-60</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>Neonatal administration of neurotoxic doses of monosodium-
l-glutamate (MSG) to rats causes neuronal necrosis of the hypothalamus along with behavioral abnormalities. In the present study the behavioral effects in rats treated with subneurotoxic doses of MSG (2 mg/g, p.o., for 10 days) at the weaned stage were investigated at day 90 post-dosing. The MSG-treated rats did not show significant changes in any of the components of spontaneous locomotor activity but, after apomorphine challenge, marked decreases in the distance travelled, ambulatory and stereotypic times, and the number of stereotypic movements with an increase in the resting time were observed. Significant decrease in the active avoidance learning performance was observed in the MSG-treated rats in the learning (acquisition) phase without any changes in the extinction and relearning phases. The results indicate that exposure to MSG in early life in rats could lead to subtle behavioral aberrations in late adulthood.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>10771161</pmid><doi>10.1016/S0304-3940(00)00958-7</doi><tpages>4</tpages></addata></record> |
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| subjects | Age Factors Animals Apomorphine - pharmacology Biological and medical sciences Brain - drug effects Brain - physiology Dopamine Agonists - pharmacology Food toxicology Learning Learning Disorders - etiology Locomotor Activity Male Medical sciences Monosodium- l-glutamate Movement Disorders - etiology Neurons - drug effects Neurons - metabolism Rat Rats Rats, Inbred Strains Receptors, N-Methyl-D-Aspartate - drug effects Receptors, N-Methyl-D-Aspartate - metabolism Sodium Glutamate - adverse effects Subneuroxic dose Toxicology Weaning |
| title | Locomotor and learning deficits in adult rats exposed to monosodium- l-glutamate during early life |
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