Metabolism of roquinimex in mouse and rat: an in vitro/in vivo comparison

1.1. In vitro studies with roquinimex, animmuno-modulator, in liver microsomes from mouse and rat were conducted to evaluate the primary metabolism and compare the metabolite pattern as well as the rate of metabolismwith the in vivo pharmacokinetics of the compound in these two species. 2. In the pr...

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Veröffentlicht in:	Xenobiotica 2000-04, Vol.30 (4), p.371-380
Hauptverfasser:	Tuvesson, H., Strandgarden, K., Nordle, O., Gunnarsson, P. O., Seidegard, J., Persson, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Adjuvants, Immunologic - metabolism Adjuvants, Immunologic - pharmacokinetics Animals Aryl Hydrocarbon Hydroxylases Biological and medical sciences Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme System - metabolism Hydroxyquinolines - administration & dosage Hydroxyquinolines - metabolism Hydroxyquinolines - pharmacokinetics Immunomodulators Medical sciences Mice Microsomes, Liver - metabolism NADP - metabolism Oxidoreductases, N-Demethylating - metabolism Pharmacology. Drug treatments Rats roquinimex Species Specificity
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