Decreased beta -Amyloid sub(1-42) and Increased Tau Levels in Cerebrospinal Fluid of Patients With Alzheimer Disease

Alzheimer disease (AD) is characterized by pathological results at autopsy of amyloid plaques and tau-associated neurofibrillary tangles, but the clinical diagnosis of AD is determined on the basis of medical history, cognitive symptoms, and exclusionary criteria. The search for antemortem biomarker...

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Veröffentlicht in:JAMA : the journal of the American Medical Association 2003-04, Vol.289 (16), p.2094-2103
Hauptverfasser: Sunderland, T, Linker, G, Mirza, N, Putnam, K T, Friedman, D L, Kimmel, L H, Bergeson, J, Manetti, G J, Zimmermann, M, Tang, B, Bartko, J J, Cohen, R M
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Sprache:eng
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