Brain α7 Nicotinic Acetylcholine Receptor Assembly Requires NACHO

Nicotine exerts its behavioral and additive actions through a family of brain nicotinic acetylcholine receptors (nAChRs). Enhancing α7-type nAChR signaling improves symptoms in Alzheimer’s disease and schizophrenia. The pharmaceutical study of α7 receptors is hampered because these receptors do not...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2016-03, Vol.89 (5), p.948-955
Hauptverfasser:	Gu, Shenyan, Matta, Jose A., Lord, Brian, Harrington, Anthony W., Sutton, Steven W., Davini, Weston B., Bredt, David S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Action Potentials - drug effects Action Potentials - genetics alpha7 Nicotinic Acetylcholine Receptor - genetics alpha7 Nicotinic Acetylcholine Receptor - metabolism Animals Calnexin - metabolism Glial Fibrillary Acidic Protein - genetics Glial Fibrillary Acidic Protein - metabolism Glutamic Acid - pharmacology HEK293 Cells Hippocampus - cytology Hippocampus - metabolism Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Isoxazoles - pharmacology Male Membrane Proteins - drug effects Membrane Proteins - metabolism Mice Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Neurons - drug effects Neurons - physiology Phenylurea Compounds - pharmacology Protein Subunits - genetics Protein Subunits - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Serotonin - pharmacology
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