The Mechanism of Adaptation of Breast Cancer Cells to Hypoxia: Role of AMPK/mTOR Signaling Pathway

We studied the mechanisms of adaptation of human breast cancer cells MCF-7 to hypoxia and analyzed the role of AMPK/mTOR signaling pathway in the maintenance of cell proliferation under hypoxic conditions. It was found that long-term culturing (30 days or more) of MCF-7 cells under hypoxic condition...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2016-02, Vol.160 (4), p.555-559
Hauptverfasser:	Sorokin, D. V., Scherbakov, A. M., Yakushina, I. A., Semina, S. E., Gudkova, M. V., Krasil’nikov, M. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological - physiology AMP-Activated Protein Kinases - metabolism Biomedical and Life Sciences Biomedicine Breast cancer Breast Neoplasms - metabolism Cancer cells Cell Biology Cell Hypoxia - physiology Cell Line, Tumor Cell Proliferation Development and progression Enzyme Activation Female Humans Internal Medicine Laboratory Medicine MCF-7 Cells Pathology TOR Serine-Threonine Kinases - metabolism
Online-Zugang:	Volltext
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