Incretinomimetic and Insulinomimetic Effect of (2E)-N′-(1′-Naphthyl)-3,4,5-Trimethoxybenzohydrazide for Glycemic Homeostasis

ABSTRACT To characterize the role and the mechanism of action of (2E)‐N′‐(1′‐naphthyl)‐3,4,5‐trimethoxybenzohydrazide (BZD) on incretin secretion, glucose uptake in skeletal muscle and α‐glucosidase activity on intestine, targets for glucose homeostasis. It was assayed on glucose tolerance test (GTT...

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Veröffentlicht in:	Journal of cellular biochemistry 2016-05, Vol.117 (5), p.1199-1209
Hauptverfasser:	Silva Frederico, Marisa Jádna, Mascarello, Alessandra, Castro, Allisson Jhonatan Gomes, Da Luz, Gabrielle, Altenhofen, Delsi, Mendes, Camila Pires, Leal, Paulo Cesar, Yunes, Rosendo Augusto, Nunes, Ricardo José, Silva, Fátima Regina Mena Barreto
Format:	Artikel
Sprache:	eng
Schlagworte:	(2E)-N′-(1′-NAPHTHYL)-3 (2E)‐N′‐(1′‐NAPHTHYL)‐3,4,5‐TRIMETHOXYBENZOHYDRAZIDE 5-TRIMETHOXYBENZOHYDRAZIDE Animals Anisoles - pharmacology Blood Glucose - metabolism Dipeptidyl Peptidase 4 - metabolism DISACCHARIDASES Disaccharidases - metabolism GLP-1 Glucagon-Like Peptide 1 - metabolism Glucose - metabolism Glucose - pharmacokinetics Glucose Tolerance Test Glucose Transporter Type 4 - metabolism GLUCOSE UPTAKE GLUT4 Homeostasis - drug effects Hydrazones - pharmacology Hypoglycemic Agents - pharmacology Immunoblotting Incretins - metabolism Insulin - metabolism Insulin Secretion Intestine, Small - drug effects Intestine, Small - enzymology Male MAP Kinase Signaling System - drug effects Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Phosphatidylinositol 3-Kinases - metabolism Protein Biosynthesis - drug effects Protein Transport - drug effects Rats, Wistar
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