Healthy HLA-DQ2.5+ Subjects Lack Regulatory and Memory T Cells Specific for Immunodominant Gluten Epitopes of Celiac Disease

Celiac disease (CD) is an HLA-associated disorder characterized by a harmful T cell response to dietary gluten. It is not understood why most individuals who carry CD-associated HLA molecules, such as HLA-DQ2.5, do not develop CD despite continuous gluten exposure. In this study, we have used tetram...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The Journal of immunology (1950) 2016-03, Vol.196 (6), p.2819-2826
Hauptverfasser:	Christophersen, Asbjørn, Risnes, Louise F, Bergseng, Elin, Lundin, Knut E A, Sollid, Ludvig M, Qiao, Shuo-Wang
Format:	Artikel
Sprache:	eng
Schlagworte:	Celiac Disease - immunology Cell Line Cell Proliferation Clonal Selection, Antigen-Mediated Cytokines - metabolism Forkhead Transcription Factors - metabolism Glutens - immunology HLA-DQ Antigens - metabolism Humans Immunodominant Epitopes - immunology Immunologic Memory Interleukin-2 Receptor alpha Subunit - metabolism Lymphocyte Activation T-Lymphocyte Subsets - immunology T-Lymphocytes, Regulatory - immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!