Aging and the environment affect gamete and embryo potential: can we intervene?

Optimal maturation of the oocyte depends on its environment and determines embryo competence, because the embryonic genome is not active until the cleavage stage and new mitochondria are not produced until blastulation. Adverse environmental factors include aging, andropause, oxidative stress, obesi...

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Veröffentlicht in:	Fertility and sterility 2016-03, Vol.105 (3), p.548-559
Hauptverfasser:	Meldrum, David R., M.D, Casper, Robert F., M.D, Diez-Juan, Antonio, Ph.D, Simon, Carlos, M.D., Ph.D, Domar, Alice D., Ph.D, Frydman, Rene, M.D., Ph.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Aging Animals Blastocyst - metabolism Blastocyst - pathology coenzyme Q10 DNA, Mitochondrial - metabolism Embryo Transfer Energy Metabolism Environment Female Fertility Fertilization in Vitro Infertility - diagnosis Infertility - physiopathology Infertility - therapy Internal Medicine Life Style lifestyle Male Maternal Health Mitochondria - metabolism Mitochondria - pathology mitochondrial DNA Obstetrics and Gynecology oocyte quality Oocyte Retrieval Oocytes - metabolism Oocytes - pathology Pregnancy Reproductive Techniques, Assisted - adverse effects Risk Factors Risk Reduction Behavior Spermatozoa - metabolism Spermatozoa - pathology Stress, Physiological Stress, Psychological - complications Treatment Outcome
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