Nonalcoholic fatty liver is not associated with incident chronic kidney disease: a large histology-based comparison with healthy individuals
BACKGROUNDNonalcoholic steatohepatitis or fibrosis is associated with the increased prevalence of impaired kidney function. It is not known whether nonalcoholic fatty liver (NAFL), which is steatosis without inflammation or fibrosis, is associated with renal impairment as these individuals are not c...
Gespeichert in:
| Veröffentlicht in: | European journal of gastroenterology & hepatology 2016-04, Vol.28 (4), p.441-443 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 443 |
|---|---|
| container_issue | 4 |
| container_start_page | 441 |
| container_title | European journal of gastroenterology & hepatology |
| container_volume | 28 |
| creator | Choudhary, Narendra S Saraf, Neeraj Kumar, Naveen Rai, Rahul Saigal, Sanjiv Gautam, Dheeraj Lipi, Lipika Rastogi, Amit Goja, Sanjay Bhangui, Prashant Ramchandra, Sumana K Soin, Arvinder S |
| description | BACKGROUNDNonalcoholic steatohepatitis or fibrosis is associated with the increased prevalence of impaired kidney function. It is not known whether nonalcoholic fatty liver (NAFL), which is steatosis without inflammation or fibrosis, is associated with renal impairment as these individuals are not candidates for liver biopsy.
MATERIALS AND METHODSThe study group included all liver donors who underwent a preoperative liver biopsy for various reasons. NAFL was defined as more than 5% hepatocytes having steatosis and no changes of steatohepatitis and/or fibrosis. Individuals with NAFL were compared with individuals with normal liver histology. Estimated glomerular filtration rate was calculated with the Modification of Diet in Renal Disease and Chronic Kidney Disease Epidemiology Collaboration methods.
RESULTSThe mean age of the study group was 35±10.3 years and the mean BMI was 26±3.2 kg/m. A total of 187 adults having NAFL (80 men) were compared with 186 (88 men) individuals with normal liver histology (controls). Individuals with steatosis had significantly higher BMI (26.8±3.5 vs. 25.5±3.8 kg/m, P |
| doi_str_mv | 10.1097/MEG.0000000000000531 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1770867134</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1770867134</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3051-3904f16b302aac3f699aae699de8bf0b0a6a6d8759bbb07481ea8610d585e2de3</originalsourceid><addsrcrecordid>eNp9UcFu1TAQtBAVfS38AUI-ckmxnxPb4Yaq0lYq9AISt2hjbxpTv_hhO33KP_DRNUpBiAN72JFWM7PSDCGvOTvjrFXvPl1cnrG_pxH8GdnwWomqkVo9JxvWNnUlW_7tmJyk9J0xrgRXL8jxVkoha6Y35OfnMIE3YQzeGTpAzgv17gEjdYlOIVNIKRgHGS09uDxSNxlnccrUjDFMRXPv7IQLtS4hJHxPgXqId0hHl3Lw4W6p-nK31ITdHqJLYVqNRgSfx6UYWvfg7Aw-vSRHQwF89YSn5OvHiy_nV9XN7eX1-YebygjW8Eq0rB647AXbAhgxyLYFwLIt6n5gPQMJ0mrVtH3fM1VrjqAlZ7bRDW4tilPydvXdx_BjxpS7nUsGvYcJw5w6rhTTUnFRF2q9Uk0MKUUcun10O4hLx1n3q4eu9ND920ORvXn6MPc7tH9Ev4MvBL0SDsFnjOnezweM3RrK_70fAXLDl6M</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1770867134</pqid></control><display><type>article</type><title>Nonalcoholic fatty liver is not associated with incident chronic kidney disease: a large histology-based comparison with healthy individuals</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>Choudhary, Narendra S ; Saraf, Neeraj ; Kumar, Naveen ; Rai, Rahul ; Saigal, Sanjiv ; Gautam, Dheeraj ; Lipi, Lipika ; Rastogi, Amit ; Goja, Sanjay ; Bhangui, Prashant ; Ramchandra, Sumana K ; Soin, Arvinder S</creator><creatorcontrib>Choudhary, Narendra S ; Saraf, Neeraj ; Kumar, Naveen ; Rai, Rahul ; Saigal, Sanjiv ; Gautam, Dheeraj ; Lipi, Lipika ; Rastogi, Amit ; Goja, Sanjay ; Bhangui, Prashant ; Ramchandra, Sumana K ; Soin, Arvinder S</creatorcontrib><description>BACKGROUNDNonalcoholic steatohepatitis or fibrosis is associated with the increased prevalence of impaired kidney function. It is not known whether nonalcoholic fatty liver (NAFL), which is steatosis without inflammation or fibrosis, is associated with renal impairment as these individuals are not candidates for liver biopsy.
MATERIALS AND METHODSThe study group included all liver donors who underwent a preoperative liver biopsy for various reasons. NAFL was defined as more than 5% hepatocytes having steatosis and no changes of steatohepatitis and/or fibrosis. Individuals with NAFL were compared with individuals with normal liver histology. Estimated glomerular filtration rate was calculated with the Modification of Diet in Renal Disease and Chronic Kidney Disease Epidemiology Collaboration methods.
RESULTSThe mean age of the study group was 35±10.3 years and the mean BMI was 26±3.2 kg/m. A total of 187 adults having NAFL (80 men) were compared with 186 (88 men) individuals with normal liver histology (controls). Individuals with steatosis had significantly higher BMI (26.8±3.5 vs. 25.5±3.8 kg/m, P<0.001) and serum alanine transaminase levels (33.8±13.3 vs. 27.2±9.8 IU/l, P<0.000). There was no significant difference in the estimated glomerular filtration rate between the normal histology group and the NAFL group with Modification of Diet in Renal Disease (115±21.8 vs. 114.4±23.2 ml/min, P=0.803) and Chronic Kidney Disease Epidemiology Collaboration methods (113.6±14.8 vs. 113±14.7 ml/min, P=0.668). There was no significant difference as regards serum creatinine (0.73±0.16 vs. 0.74±0.16 mg%, P=0.536), proteinuria (P=0.121), diabetes (1 vs. 4, P=0.372), and hypertension (2 vs. 6, P=0.174) in individuals of both groups.
CONCLUSIONPresence of NAFL does not adversely affect renal function.</description><identifier>ISSN: 0954-691X</identifier><identifier>EISSN: 1473-5687</identifier><identifier>DOI: 10.1097/MEG.0000000000000531</identifier><identifier>PMID: 26636408</identifier><language>eng</language><publisher>England: Copyright Wolters Kluwer Health, Inc. All rights reserved</publisher><subject>Adult ; Biopsy ; Female ; Glomerular Filtration Rate ; Humans ; Incidence ; India - epidemiology ; Kidney - physiopathology ; Liver - pathology ; Male ; Middle Aged ; Non-alcoholic Fatty Liver Disease - diagnosis ; Non-alcoholic Fatty Liver Disease - epidemiology ; Non-alcoholic Fatty Liver Disease - pathology ; Predictive Value of Tests ; Renal Insufficiency, Chronic - diagnosis ; Renal Insufficiency, Chronic - epidemiology ; Renal Insufficiency, Chronic - physiopathology ; Retrospective Studies ; Risk Factors</subject><ispartof>European journal of gastroenterology & hepatology, 2016-04, Vol.28 (4), p.441-443</ispartof><rights>Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3051-3904f16b302aac3f699aae699de8bf0b0a6a6d8759bbb07481ea8610d585e2de3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26636408$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Choudhary, Narendra S</creatorcontrib><creatorcontrib>Saraf, Neeraj</creatorcontrib><creatorcontrib>Kumar, Naveen</creatorcontrib><creatorcontrib>Rai, Rahul</creatorcontrib><creatorcontrib>Saigal, Sanjiv</creatorcontrib><creatorcontrib>Gautam, Dheeraj</creatorcontrib><creatorcontrib>Lipi, Lipika</creatorcontrib><creatorcontrib>Rastogi, Amit</creatorcontrib><creatorcontrib>Goja, Sanjay</creatorcontrib><creatorcontrib>Bhangui, Prashant</creatorcontrib><creatorcontrib>Ramchandra, Sumana K</creatorcontrib><creatorcontrib>Soin, Arvinder S</creatorcontrib><title>Nonalcoholic fatty liver is not associated with incident chronic kidney disease: a large histology-based comparison with healthy individuals</title><title>European journal of gastroenterology & hepatology</title><addtitle>Eur J Gastroenterol Hepatol</addtitle><description>BACKGROUNDNonalcoholic steatohepatitis or fibrosis is associated with the increased prevalence of impaired kidney function. It is not known whether nonalcoholic fatty liver (NAFL), which is steatosis without inflammation or fibrosis, is associated with renal impairment as these individuals are not candidates for liver biopsy.
MATERIALS AND METHODSThe study group included all liver donors who underwent a preoperative liver biopsy for various reasons. NAFL was defined as more than 5% hepatocytes having steatosis and no changes of steatohepatitis and/or fibrosis. Individuals with NAFL were compared with individuals with normal liver histology. Estimated glomerular filtration rate was calculated with the Modification of Diet in Renal Disease and Chronic Kidney Disease Epidemiology Collaboration methods.
RESULTSThe mean age of the study group was 35±10.3 years and the mean BMI was 26±3.2 kg/m. A total of 187 adults having NAFL (80 men) were compared with 186 (88 men) individuals with normal liver histology (controls). Individuals with steatosis had significantly higher BMI (26.8±3.5 vs. 25.5±3.8 kg/m, P<0.001) and serum alanine transaminase levels (33.8±13.3 vs. 27.2±9.8 IU/l, P<0.000). There was no significant difference in the estimated glomerular filtration rate between the normal histology group and the NAFL group with Modification of Diet in Renal Disease (115±21.8 vs. 114.4±23.2 ml/min, P=0.803) and Chronic Kidney Disease Epidemiology Collaboration methods (113.6±14.8 vs. 113±14.7 ml/min, P=0.668). There was no significant difference as regards serum creatinine (0.73±0.16 vs. 0.74±0.16 mg%, P=0.536), proteinuria (P=0.121), diabetes (1 vs. 4, P=0.372), and hypertension (2 vs. 6, P=0.174) in individuals of both groups.
CONCLUSIONPresence of NAFL does not adversely affect renal function.</description><subject>Adult</subject><subject>Biopsy</subject><subject>Female</subject><subject>Glomerular Filtration Rate</subject><subject>Humans</subject><subject>Incidence</subject><subject>India - epidemiology</subject><subject>Kidney - physiopathology</subject><subject>Liver - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Non-alcoholic Fatty Liver Disease - diagnosis</subject><subject>Non-alcoholic Fatty Liver Disease - epidemiology</subject><subject>Non-alcoholic Fatty Liver Disease - pathology</subject><subject>Predictive Value of Tests</subject><subject>Renal Insufficiency, Chronic - diagnosis</subject><subject>Renal Insufficiency, Chronic - epidemiology</subject><subject>Renal Insufficiency, Chronic - physiopathology</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><issn>0954-691X</issn><issn>1473-5687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UcFu1TAQtBAVfS38AUI-ckmxnxPb4Yaq0lYq9AISt2hjbxpTv_hhO33KP_DRNUpBiAN72JFWM7PSDCGvOTvjrFXvPl1cnrG_pxH8GdnwWomqkVo9JxvWNnUlW_7tmJyk9J0xrgRXL8jxVkoha6Y35OfnMIE3YQzeGTpAzgv17gEjdYlOIVNIKRgHGS09uDxSNxlnccrUjDFMRXPv7IQLtS4hJHxPgXqId0hHl3Lw4W6p-nK31ITdHqJLYVqNRgSfx6UYWvfg7Aw-vSRHQwF89YSn5OvHiy_nV9XN7eX1-YebygjW8Eq0rB647AXbAhgxyLYFwLIt6n5gPQMJ0mrVtH3fM1VrjqAlZ7bRDW4tilPydvXdx_BjxpS7nUsGvYcJw5w6rhTTUnFRF2q9Uk0MKUUcun10O4hLx1n3q4eu9ND920ORvXn6MPc7tH9Ev4MvBL0SDsFnjOnezweM3RrK_70fAXLDl6M</recordid><startdate>201604</startdate><enddate>201604</enddate><creator>Choudhary, Narendra S</creator><creator>Saraf, Neeraj</creator><creator>Kumar, Naveen</creator><creator>Rai, Rahul</creator><creator>Saigal, Sanjiv</creator><creator>Gautam, Dheeraj</creator><creator>Lipi, Lipika</creator><creator>Rastogi, Amit</creator><creator>Goja, Sanjay</creator><creator>Bhangui, Prashant</creator><creator>Ramchandra, Sumana K</creator><creator>Soin, Arvinder S</creator><general>Copyright Wolters Kluwer Health, Inc. All rights reserved</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201604</creationdate><title>Nonalcoholic fatty liver is not associated with incident chronic kidney disease: a large histology-based comparison with healthy individuals</title><author>Choudhary, Narendra S ; Saraf, Neeraj ; Kumar, Naveen ; Rai, Rahul ; Saigal, Sanjiv ; Gautam, Dheeraj ; Lipi, Lipika ; Rastogi, Amit ; Goja, Sanjay ; Bhangui, Prashant ; Ramchandra, Sumana K ; Soin, Arvinder S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3051-3904f16b302aac3f699aae699de8bf0b0a6a6d8759bbb07481ea8610d585e2de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Biopsy</topic><topic>Female</topic><topic>Glomerular Filtration Rate</topic><topic>Humans</topic><topic>Incidence</topic><topic>India - epidemiology</topic><topic>Kidney - physiopathology</topic><topic>Liver - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Non-alcoholic Fatty Liver Disease - diagnosis</topic><topic>Non-alcoholic Fatty Liver Disease - epidemiology</topic><topic>Non-alcoholic Fatty Liver Disease - pathology</topic><topic>Predictive Value of Tests</topic><topic>Renal Insufficiency, Chronic - diagnosis</topic><topic>Renal Insufficiency, Chronic - epidemiology</topic><topic>Renal Insufficiency, Chronic - physiopathology</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choudhary, Narendra S</creatorcontrib><creatorcontrib>Saraf, Neeraj</creatorcontrib><creatorcontrib>Kumar, Naveen</creatorcontrib><creatorcontrib>Rai, Rahul</creatorcontrib><creatorcontrib>Saigal, Sanjiv</creatorcontrib><creatorcontrib>Gautam, Dheeraj</creatorcontrib><creatorcontrib>Lipi, Lipika</creatorcontrib><creatorcontrib>Rastogi, Amit</creatorcontrib><creatorcontrib>Goja, Sanjay</creatorcontrib><creatorcontrib>Bhangui, Prashant</creatorcontrib><creatorcontrib>Ramchandra, Sumana K</creatorcontrib><creatorcontrib>Soin, Arvinder S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of gastroenterology & hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choudhary, Narendra S</au><au>Saraf, Neeraj</au><au>Kumar, Naveen</au><au>Rai, Rahul</au><au>Saigal, Sanjiv</au><au>Gautam, Dheeraj</au><au>Lipi, Lipika</au><au>Rastogi, Amit</au><au>Goja, Sanjay</au><au>Bhangui, Prashant</au><au>Ramchandra, Sumana K</au><au>Soin, Arvinder S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nonalcoholic fatty liver is not associated with incident chronic kidney disease: a large histology-based comparison with healthy individuals</atitle><jtitle>European journal of gastroenterology & hepatology</jtitle><addtitle>Eur J Gastroenterol Hepatol</addtitle><date>2016-04</date><risdate>2016</risdate><volume>28</volume><issue>4</issue><spage>441</spage><epage>443</epage><pages>441-443</pages><issn>0954-691X</issn><eissn>1473-5687</eissn><abstract>BACKGROUNDNonalcoholic steatohepatitis or fibrosis is associated with the increased prevalence of impaired kidney function. It is not known whether nonalcoholic fatty liver (NAFL), which is steatosis without inflammation or fibrosis, is associated with renal impairment as these individuals are not candidates for liver biopsy.
MATERIALS AND METHODSThe study group included all liver donors who underwent a preoperative liver biopsy for various reasons. NAFL was defined as more than 5% hepatocytes having steatosis and no changes of steatohepatitis and/or fibrosis. Individuals with NAFL were compared with individuals with normal liver histology. Estimated glomerular filtration rate was calculated with the Modification of Diet in Renal Disease and Chronic Kidney Disease Epidemiology Collaboration methods.
RESULTSThe mean age of the study group was 35±10.3 years and the mean BMI was 26±3.2 kg/m. A total of 187 adults having NAFL (80 men) were compared with 186 (88 men) individuals with normal liver histology (controls). Individuals with steatosis had significantly higher BMI (26.8±3.5 vs. 25.5±3.8 kg/m, P<0.001) and serum alanine transaminase levels (33.8±13.3 vs. 27.2±9.8 IU/l, P<0.000). There was no significant difference in the estimated glomerular filtration rate between the normal histology group and the NAFL group with Modification of Diet in Renal Disease (115±21.8 vs. 114.4±23.2 ml/min, P=0.803) and Chronic Kidney Disease Epidemiology Collaboration methods (113.6±14.8 vs. 113±14.7 ml/min, P=0.668). There was no significant difference as regards serum creatinine (0.73±0.16 vs. 0.74±0.16 mg%, P=0.536), proteinuria (P=0.121), diabetes (1 vs. 4, P=0.372), and hypertension (2 vs. 6, P=0.174) in individuals of both groups.
CONCLUSIONPresence of NAFL does not adversely affect renal function.</abstract><cop>England</cop><pub>Copyright Wolters Kluwer Health, Inc. All rights reserved</pub><pmid>26636408</pmid><doi>10.1097/MEG.0000000000000531</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0954-691X |
| ispartof | European journal of gastroenterology & hepatology, 2016-04, Vol.28 (4), p.441-443 |
| issn | 0954-691X 1473-5687 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1770867134 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Biopsy Female Glomerular Filtration Rate Humans Incidence India - epidemiology Kidney - physiopathology Liver - pathology Male Middle Aged Non-alcoholic Fatty Liver Disease - diagnosis Non-alcoholic Fatty Liver Disease - epidemiology Non-alcoholic Fatty Liver Disease - pathology Predictive Value of Tests Renal Insufficiency, Chronic - diagnosis Renal Insufficiency, Chronic - epidemiology Renal Insufficiency, Chronic - physiopathology Retrospective Studies Risk Factors |
| title | Nonalcoholic fatty liver is not associated with incident chronic kidney disease: a large histology-based comparison with healthy individuals |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T19%3A08%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Nonalcoholic%20fatty%20liver%20is%20not%20associated%20with%20incident%20chronic%20kidney%20disease:%20a%20large%20histology-based%20comparison%20with%20healthy%20individuals&rft.jtitle=European%20journal%20of%20gastroenterology%20&%20hepatology&rft.au=Choudhary,%20Narendra%20S&rft.date=2016-04&rft.volume=28&rft.issue=4&rft.spage=441&rft.epage=443&rft.pages=441-443&rft.issn=0954-691X&rft.eissn=1473-5687&rft_id=info:doi/10.1097/MEG.0000000000000531&rft_dat=%3Cproquest_cross%3E1770867134%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1770867134&rft_id=info:pmid/26636408&rfr_iscdi=true |