A rapid UPLC-MS/MS method for the determination of oleanolic acid in rat plasma and liver tissue: application to plasma and liver pharmacokinetics

A reliable high‐throughput ultra‐high performance liquid chromatography–tandem mass spectrometry (UPLC‐MS/MS) method was developed and validated for oleanolic acid (OA) determination in rat plasma and liver tissue using glycyrrhetic acid as the internal standard (IS). Plasma and liver homogenate sam...

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Veröffentlicht in:	Biomedical chromatography 2016-04, Vol.30 (4), p.520-527
Hauptverfasser:	Li, Tian-xue, Chu, Chao-sen, Zhu, Jia-yu, Yang, Tian-yi, Zhang, Jie, Hu, Yu-tao, Yang, Xing-hao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals bio-analysis Chromatography, High Pressure Liquid - methods Limit of Detection Liquid-Liquid Extraction - methods Liver - chemistry liver tissue Male oleanolic acid Oleanolic Acid - analysis Oleanolic Acid - blood Rats Rats, Sprague-Dawley Reproducibility of Results solid-phase extraction Tandem Mass Spectrometry - methods UPLC-MS/MS
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