Fosmidomycin-Clindamycin for the Treatment of Plasmodium falciparum Malaria

It has been demonstrated that fosmidomycin has good tolerability and rapid onset of action, but late recrudescences preclude its use alone; in vitro, clindamycin has been shown to act synergistically with fosmidomycin against Plasmodium falciparum. We conducted a study in pediatric outpatients with...

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Veröffentlicht in:	The Journal of infectious diseases 2004-11, Vol.190 (9), p.1534-1540
Hauptverfasser:	Borrmann, Steffen, Issifou, Saadou, Esser, Gilbert, Adegnika, Ayola A., Ramharter, Michael, Matsiegui, Pierre-Blaise, Oyakhirome, Sunny, Mboumba, Dénise P. Mawili, Missinou, Michel A., Kun, Jürgen F. J., Jomaa, Hassan, Kremsner, Peter G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adolescent Animals Antimalarials Antimalarials - administration & dosage Antimalarials - adverse effects Antimalarials - pharmacology Antimalarials - therapeutic use Biological and medical sciences Blood - parasitology Blood plasma Child Clindamycin - administration & dosage Clindamycin - adverse effects Clindamycin - pharmacology Clindamycin - therapeutic use Dosage Drug Therapy, Combination - therapeutic use Falciparum malaria Female Fever Fosfomycin - administration & dosage Fosfomycin - adverse effects Fosfomycin - analogs & derivatives Fosfomycin - pharmacology Fosfomycin - therapeutic use Fundamental and applied biological sciences. Psychology Gabon Human protozoal diseases Humans Infections Infectious diseases Malaria Malaria, Falciparum - drug therapy Malaria, Falciparum - parasitology Male Medical cures Medical sciences Microbiology Parasitemia Parasites Parasitic diseases Parasitology Plasmodium falciparum Plasmodium falciparum - drug effects Plasmodium falciparum - isolation & purification Protozoal diseases
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