Receptor Engagement on Cells Expressing a Ligand for the Tolerance-Inducing Molecule OX2 Induces an Immunoregulatory Population That Inhibits Alloreactivity In Vitro and In Vivo

Increased survival of C57BL/6 renal allografts following portal vein donor-specific pretransplant immunization of C3H mice is associated with increased expression of the molecule OX2 seen on host dendritic cells, along with a marked polarization in cytokine production from lymphocytes harvested from...

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Veröffentlicht in:	The Journal of immunology (1950) 2000-11, Vol.165 (9), p.4854-4860
Hauptverfasser:	Gorczynski, Reginald M, Yu, Kai, Clark, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen-Presenting Cells - immunology Antigens, CD Antigens, Surface - biosynthesis Antigens, Surface - metabolism Binding Sites, Antibody - genetics Cell Adhesion - genetics Cell Adhesion - immunology Cell Separation Cells, Cultured Cytotoxicity, Immunologic Dendritic Cells - immunology Dendritic Cells - metabolism Fluorescein-5-isothiocyanate - metabolism Graft Rejection - genetics Graft Rejection - immunology Graft Rejection - prevention & control Histocompatibility Testing Immune Tolerance - genetics Immunoglobulin Fc Fragments - genetics Immunoglobulin Fc Fragments - metabolism Isoantigens - immunology Ligands Lipopolysaccharides - pharmacology Lymphocyte Activation - immunology Male Mice Mice, Inbred BALB C Mice, Inbred C3H Mice, Inbred C57BL OX2 antigen OX2L protein Receptors, Antigen, T-Cell, alpha-beta - immunology Receptors, Antigen, T-Cell, alpha-beta - metabolism Receptors, Antigen, T-Cell, gamma-delta - immunology Receptors, Antigen, T-Cell, gamma-delta - metabolism Recombinant Fusion Proteins - immunology Recombinant Fusion Proteins - metabolism Recombinant Fusion Proteins - pharmacology Spleen - cytology Spleen - immunology Spleen - metabolism T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Cytotoxic - metabolism
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