Respiratory Disease in Aggregate Quarry Workers Related to Risk Factors and Pi Phenotype
Objective: To evaluate the respiratory health and its relationship with exposure to silica, smoking, α 1-antitrypsin, and Pi phenotype in aggregate quarries workers. Methods: In a prevalence study, 378 subjects were studied, x-ray opacities and pulmonary function was analyzed in relation to cumulati...
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| Veröffentlicht in: | Journal of occupational and environmental medicine 2004-11, Vol.46 (11), p.1150-1157 |
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| creator | Montes, Isabel Isidro Rego, G. Camblor, C. Quero, A. González, A. Rodríguez, C. |
| description | Objective: To evaluate the respiratory health and its relationship with exposure to silica, smoking, α 1-antitrypsin, and Pi phenotype in aggregate quarries workers. Methods: In a prevalence study, 378 subjects were studied, x-ray opacities and pulmonary function was analyzed in relation to cumulative dust exposure, smoking, α1-antitrypsin, and Pi phenotype. Results: The adjusted odds ratio (OR) of round opacities (≥0/1) was significantly related to smoking (P < 0.001). The predicted forced expiratory volume in 1 second (FEV₁) percentage had a negative relationship with the product dust pack-years (P = 0.005). The OR of FEV₁ |
| doi_str_mv | 10.1097/01.jom.0000141662.18277.07 |
| format | Article |
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Methods: In a prevalence study, 378 subjects were studied, x-ray opacities and pulmonary function was analyzed in relation to cumulative dust exposure, smoking, α1-antitrypsin, and Pi phenotype. Results: The adjusted odds ratio (OR) of round opacities (≥0/1) was significantly related to smoking (P < 0.001). The predicted forced expiratory volume in 1 second (FEV₁) percentage had a negative relationship with the product dust pack-years (P = 0.005). The OR of FEV₁ <90% was 3.03 for smokers exposed to dust versus nonexposed nonsmokers (P = 0.049). The criteria for dust-tobacco interaction are satisfied. A subgroup with the highest level of α1-antitrypsin presented more opacities and worse pulmonary function. Conclusions: Radiologic alterations are found in relation to tobacco. The FEV₁ has a negative relation with the product dust-tobacco. No alterations related to Pi phenotype are found. A subgroup with the highest α₁-antitrypsin levels had more radiologic alterations and worse function.</description><identifier>ISSN: 1076-2752</identifier><identifier>EISSN: 1536-5948</identifier><identifier>DOI: 10.1097/01.jom.0000141662.18277.07</identifier><identifier>PMID: 15534502</identifier><identifier>CODEN: JOEMFM</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; Aged ; Air Pollutants, Occupational - toxicity ; alpha 1-Antitrypsin - metabolism ; alpha 1-Antitrypsin Deficiency - epidemiology ; Analysis of Variance ; Biological and medical sciences ; Chemical and industrial products toxicology. Toxic occupational diseases ; Chi-Square Distribution ; Dust ; Female ; Human exposure ; Humans ; Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.) ; Lung Diseases, Obstructive - diagnostic imaging ; Lung Diseases, Obstructive - epidemiology ; Lung Diseases, Obstructive - etiology ; Male ; Medical sciences ; Middle Aged ; Occupational Diseases - diagnostic imaging ; Occupational Diseases - epidemiology ; Occupational Diseases - etiology ; Occupational Exposure ; Occupational health ; ORIGINAL ARTICLES ; Phenotype ; Pneumoconiosis - diagnostic imaging ; Pneumoconiosis - epidemiology ; Pneumoconiosis - etiology ; Prevalence ; Radiography ; Regression Analysis ; Respiratory diseases ; Respiratory Function Tests ; Risk Factors ; Silica ; Silicon Dioxide - toxicity ; Smoking ; Smoking - adverse effects ; Studies ; Toxicology</subject><ispartof>Journal of occupational and environmental medicine, 2004-11, Vol.46 (11), p.1150-1157</ispartof><rights>Copyright © 2004 American College of Occupational and Environmental Medicine</rights><rights>2004The American College of Occupational and Environmental Medicine</rights><rights>2005 INIST-CNRS</rights><rights>Copyright Lippincott Williams & Wilkins Nov 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4700-515f5119a638fa5732450cb384816e9be46844b9a59afa1ba99c931dc393319e3</citedby><cites>FETCH-LOGICAL-c4700-515f5119a638fa5732450cb384816e9be46844b9a59afa1ba99c931dc393319e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/44997376$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/44997376$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16278070$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15534502$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Montes, Isabel Isidro</creatorcontrib><creatorcontrib>Rego, G.</creatorcontrib><creatorcontrib>Camblor, C.</creatorcontrib><creatorcontrib>Quero, A.</creatorcontrib><creatorcontrib>González, A.</creatorcontrib><creatorcontrib>Rodríguez, C.</creatorcontrib><title>Respiratory Disease in Aggregate Quarry Workers Related to Risk Factors and Pi Phenotype</title><title>Journal of occupational and environmental medicine</title><addtitle>J Occup Environ Med</addtitle><description>Objective: To evaluate the respiratory health and its relationship with exposure to silica, smoking, α 1-antitrypsin, and Pi phenotype in aggregate quarries workers. Methods: In a prevalence study, 378 subjects were studied, x-ray opacities and pulmonary function was analyzed in relation to cumulative dust exposure, smoking, α1-antitrypsin, and Pi phenotype. Results: The adjusted odds ratio (OR) of round opacities (≥0/1) was significantly related to smoking (P < 0.001). The predicted forced expiratory volume in 1 second (FEV₁) percentage had a negative relationship with the product dust pack-years (P = 0.005). The OR of FEV₁ <90% was 3.03 for smokers exposed to dust versus nonexposed nonsmokers (P = 0.049). The criteria for dust-tobacco interaction are satisfied. A subgroup with the highest level of α1-antitrypsin presented more opacities and worse pulmonary function. Conclusions: Radiologic alterations are found in relation to tobacco. The FEV₁ has a negative relation with the product dust-tobacco. No alterations related to Pi phenotype are found. A subgroup with the highest α₁-antitrypsin levels had more radiologic alterations and worse function.</description><subject>Adult</subject><subject>Aged</subject><subject>Air Pollutants, Occupational - toxicity</subject><subject>alpha 1-Antitrypsin - metabolism</subject><subject>alpha 1-Antitrypsin Deficiency - epidemiology</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Chi-Square Distribution</subject><subject>Dust</subject><subject>Female</subject><subject>Human exposure</subject><subject>Humans</subject><subject>Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.)</subject><subject>Lung Diseases, Obstructive - diagnostic imaging</subject><subject>Lung Diseases, Obstructive - epidemiology</subject><subject>Lung Diseases, Obstructive - etiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Occupational Diseases - diagnostic imaging</subject><subject>Occupational Diseases - epidemiology</subject><subject>Occupational Diseases - etiology</subject><subject>Occupational Exposure</subject><subject>Occupational health</subject><subject>ORIGINAL ARTICLES</subject><subject>Phenotype</subject><subject>Pneumoconiosis - diagnostic imaging</subject><subject>Pneumoconiosis - epidemiology</subject><subject>Pneumoconiosis - etiology</subject><subject>Prevalence</subject><subject>Radiography</subject><subject>Regression Analysis</subject><subject>Respiratory diseases</subject><subject>Respiratory Function Tests</subject><subject>Risk Factors</subject><subject>Silica</subject><subject>Silicon Dioxide - toxicity</subject><subject>Smoking</subject><subject>Smoking - adverse effects</subject><subject>Studies</subject><subject>Toxicology</subject><issn>1076-2752</issn><issn>1536-5948</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkVuP0zAQhSMEYi_wE0DWSvCW4IlvMW-rhQWklVgqELxZTjpp06Zx10606r_fKa2ohF88tr8zc3ScZVfAC-DWfOBQrMKm4LRAgtZlAVVpTMHNs-wclNC5srJ6TjU3Oi-NKs-yi5RWhCvg6mV2BkoJqXh5nv2ZYdp20Y8h7tinLqFPyLqBXS8WERd-RPZj8pHefoe4xpjYDHu6nbMxsFmX1uzWN6RNzA9zdt-x-yUOYdxt8VX2ovV9wtfH_TL7dfv5583X_O77l28313d5Iw3nuQLVKgDrtahar4woyVdTi0pWoNHWKHUlZW29sr71UHtrGytg3ggrBFgUl9n7Q99tDA8TptFtutRg3_sBw5QcGMMN1xWBV_-BqzDFgby5EkptOdeWoI8HqIkhpYit28Zu4-POAXf78B0H0m3cKXz3N3zHDYnfHidM9QbnJ-kxbQLeHQGfGt-30Q9Nl06cLk1FZomTB-4x9COFvu6nR4xuib4fl_vRUhgt85IKADrmezN72ZuDbJXoS_61ldJaQwLxBJiJpS4</recordid><startdate>200411</startdate><enddate>200411</enddate><creator>Montes, Isabel Isidro</creator><creator>Rego, G.</creator><creator>Camblor, C.</creator><creator>Quero, A.</creator><creator>González, A.</creator><creator>Rodríguez, C.</creator><general>Lippincott Williams & Wilkins</general><general>The American College of Occupational and Environmental Medicine</general><general>Lippincott Williams & Wilkins Ovid Technologies</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>7TV</scope><scope>7U1</scope><scope>7U2</scope></search><sort><creationdate>200411</creationdate><title>Respiratory Disease in Aggregate Quarry Workers Related to Risk Factors and Pi Phenotype</title><author>Montes, Isabel Isidro ; Rego, G. ; Camblor, C. ; Quero, A. ; González, A. ; Rodríguez, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4700-515f5119a638fa5732450cb384816e9be46844b9a59afa1ba99c931dc393319e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Air Pollutants, Occupational - toxicity</topic><topic>alpha 1-Antitrypsin - metabolism</topic><topic>alpha 1-Antitrypsin Deficiency - epidemiology</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Chi-Square Distribution</topic><topic>Dust</topic><topic>Female</topic><topic>Human exposure</topic><topic>Humans</topic><topic>Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.)</topic><topic>Lung Diseases, Obstructive - diagnostic imaging</topic><topic>Lung Diseases, Obstructive - epidemiology</topic><topic>Lung Diseases, Obstructive - etiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Occupational Diseases - diagnostic imaging</topic><topic>Occupational Diseases - epidemiology</topic><topic>Occupational Diseases - etiology</topic><topic>Occupational Exposure</topic><topic>Occupational health</topic><topic>ORIGINAL ARTICLES</topic><topic>Phenotype</topic><topic>Pneumoconiosis - diagnostic imaging</topic><topic>Pneumoconiosis - epidemiology</topic><topic>Pneumoconiosis - etiology</topic><topic>Prevalence</topic><topic>Radiography</topic><topic>Regression Analysis</topic><topic>Respiratory diseases</topic><topic>Respiratory Function Tests</topic><topic>Risk Factors</topic><topic>Silica</topic><topic>Silicon Dioxide - toxicity</topic><topic>Smoking</topic><topic>Smoking - adverse effects</topic><topic>Studies</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Montes, Isabel Isidro</creatorcontrib><creatorcontrib>Rego, G.</creatorcontrib><creatorcontrib>Camblor, C.</creatorcontrib><creatorcontrib>Quero, A.</creatorcontrib><creatorcontrib>González, A.</creatorcontrib><creatorcontrib>Rodríguez, C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Pollution Abstracts</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><jtitle>Journal of occupational and environmental medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Montes, Isabel Isidro</au><au>Rego, G.</au><au>Camblor, C.</au><au>Quero, A.</au><au>González, A.</au><au>Rodríguez, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Respiratory Disease in Aggregate Quarry Workers Related to Risk Factors and Pi Phenotype</atitle><jtitle>Journal of occupational and environmental medicine</jtitle><addtitle>J Occup Environ Med</addtitle><date>2004-11</date><risdate>2004</risdate><volume>46</volume><issue>11</issue><spage>1150</spage><epage>1157</epage><pages>1150-1157</pages><issn>1076-2752</issn><eissn>1536-5948</eissn><coden>JOEMFM</coden><abstract>Objective: To evaluate the respiratory health and its relationship with exposure to silica, smoking, α 1-antitrypsin, and Pi phenotype in aggregate quarries workers. Methods: In a prevalence study, 378 subjects were studied, x-ray opacities and pulmonary function was analyzed in relation to cumulative dust exposure, smoking, α1-antitrypsin, and Pi phenotype. Results: The adjusted odds ratio (OR) of round opacities (≥0/1) was significantly related to smoking (P < 0.001). The predicted forced expiratory volume in 1 second (FEV₁) percentage had a negative relationship with the product dust pack-years (P = 0.005). The OR of FEV₁ <90% was 3.03 for smokers exposed to dust versus nonexposed nonsmokers (P = 0.049). The criteria for dust-tobacco interaction are satisfied. A subgroup with the highest level of α1-antitrypsin presented more opacities and worse pulmonary function. Conclusions: Radiologic alterations are found in relation to tobacco. The FEV₁ has a negative relation with the product dust-tobacco. No alterations related to Pi phenotype are found. A subgroup with the highest α₁-antitrypsin levels had more radiologic alterations and worse function.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>15534502</pmid><doi>10.1097/01.jom.0000141662.18277.07</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Aged Air Pollutants, Occupational - toxicity alpha 1-Antitrypsin - metabolism alpha 1-Antitrypsin Deficiency - epidemiology Analysis of Variance Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Chi-Square Distribution Dust Female Human exposure Humans Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.) Lung Diseases, Obstructive - diagnostic imaging Lung Diseases, Obstructive - epidemiology Lung Diseases, Obstructive - etiology Male Medical sciences Middle Aged Occupational Diseases - diagnostic imaging Occupational Diseases - epidemiology Occupational Diseases - etiology Occupational Exposure Occupational health ORIGINAL ARTICLES Phenotype Pneumoconiosis - diagnostic imaging Pneumoconiosis - epidemiology Pneumoconiosis - etiology Prevalence Radiography Regression Analysis Respiratory diseases Respiratory Function Tests Risk Factors Silica Silicon Dioxide - toxicity Smoking Smoking - adverse effects Studies Toxicology |
| title | Respiratory Disease in Aggregate Quarry Workers Related to Risk Factors and Pi Phenotype |
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