Chimeric immune receptors (CIRs) specific to JC virus for immunotherapy in progressive multifocal leukoencephalopathy (PML)

Progressive multifocal leukoencephalopathy (PML) is a deadly brain disease caused by the polyomavirus JC (JCV). The aim of this study is to develop ‘designer T cells’ armed with anti-JCV TCR-based chimeric immune receptors (CIRs) by gene modification for PML immunotherapy. Two T cell lines specific...

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Veröffentlicht in:	International immunology 2007-09, Vol.19 (9), p.1083-1093
Hauptverfasser:	Yang, W, Beaudoin, EL, Lu, L, Du Pasquier, RA, Kuroda, MJ, Willemsen, RA, Koralnik, IJ, Junghans, RP
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigen-Antibody Reactions Cell Line Cell Proliferation - drug effects Cloning, Molecular Cytokines - biosynthesis Cytokines - secretion Cytotoxicity Tests, Immunologic Disease Progression gene transfer Humans Immunotherapy JC virus JC Virus - immunology Leukoencephalopathy, Progressive Multifocal - therapy Peptides - pharmacology Polyomavirus Receptors, Antigen, T-Cell, alpha-beta - genetics Receptors, Antigen, T-Cell, alpha-beta - immunology Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - immunology retroviral transduction Sensitivity and Specificity T cell T-Lymphocytes - immunology TCR Viral Proteins - immunology
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