Acute effects of estrogen upon methamphetamine induced neurotoxicity of the nigrostriatal dopaminergic system

Estrogen acts as a neuroprotectant of the nigrostriatal dopaminergic system when given chronically to female mice prior to Methamphetamine (MA) insult. In this report, we tested the acute effects of Estradiol Benzoate (EB-10 microg in Oil) in ovariectomized CD-1 mice to function as a neuroprotectant...

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Veröffentlicht in:	Journal of Neural Transmission 2003-11, Vol.110 (11), p.1215-1224
Hauptverfasser:	GAJJAR, T. M, ANDERSON, L. I, DLUZEN, D. E
Format:	Artikel
Sprache:	eng
Schlagworte:	3,4-Dihydroxyphenylacetic Acid - metabolism Animals Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dopamine - metabolism Drug Interactions Estrogens - metabolism Estrogens - pharmacology Female Fundamental and applied biological sciences. Psychology Medical sciences Methamphetamine - antagonists & inhibitors Methamphetamine - toxicity Mice Neostriatum - drug effects Neostriatum - metabolism Neostriatum - physiopathology Neural Pathways - drug effects Neural Pathways - metabolism Neural Pathways - physiopathology Neurology Neuroprotective Agents - metabolism Neuroprotective Agents - pharmacology Neurotoxins - antagonists & inhibitors Neurotoxins - toxicity Ovariectomy Parkinson Disease - drug therapy Parkinson Disease - metabolism Parkinson Disease - physiopathology Presynaptic Terminals - drug effects Presynaptic Terminals - metabolism Reaction Time - drug effects Reaction Time - physiology Sex Factors Substantia Nigra - drug effects Substantia Nigra - metabolism Substantia Nigra - physiopathology Vertebrates: nervous system and sense organs
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